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The map label for this gene is ispH

Identifier: 78355437

GI number: 78355437

Start: 384068

End: 384913

Strand: Direct

Name: ispH

Synonym: Dde_0390

Alternate gene names: 78355437

Gene position: 384068-384913 (Clockwise)

Preceding gene: 78355436

Following gene: 78355438

Centisome position: 10.3

GC content: 58.87

Gene sequence:

>846_bases
ATGCATGTAAAACGTGCGGCCACTGCCGGTTTTTGCATGGGCGTGGGACTTGCCCTGAAAAAACTGGACAGGGAACTTGA
TAATAACGCGAAAGATATAGCCACGCTCGGCCCTATCATTCATAATCCACAGGTGCTCAGACGCTACGAGCAAAAGGGCG
TGCGCTGTTATACCGACCCTGCGGAAGCCCGTTCCGGGCAGCGGGTCGTCATACGGGCGCACGGTATTCCCGAAGAAACG
GAAAGCGCGCTTGCCGCGGCGGGGGTCGATCTGGTGGACGCCACCTGTCCCAAGGTCAAGCGTGCGCAGCTGGGCATAGC
AAGACAGCGGGAAAAAGGCCGTACGCTGTTGTTGTTCGGCGAGCATGACCATCCTGAAGTTCAGGGACTGCTGAGCTACG
CCGGAGAGGGCGCCGTGGTTTTCGGTTCGCTGGAGGAACTGCAGAACGGTCCGCTGGAAGATGACCGGCATTATTTTCTG
GCAGCCCAGACCACGCAGGATAAACATGCCTTTACAAGTGTGATAGAATGGGTGCGCCGCCGTTTCGGCGACCATGTGCC
CGTGCTGGACACCATCTGCGATGCCACCCGCGAACGGCAGGACGAAGCCATAGCCATTGCGCGCAGTGTGGATGTGATGG
TGGTGGTGGGCGGATTTGCCAGCGGTAACACGCGGCGGCTGGCCGAGGTGGCACAGGCTCAGGGTGTGCCCACATACCAT
GTGGAAACGCCGGACCAGTTGCCTCTGGACGCCATACGCGGGTATGGTGCGGCCGGACTTACTGCCGGGGCTTCCACACC
CAAGAGTATTATTGACGAGACCCAGAAATTGTTGGAGTCTTTGTAA

Upstream 100 bases:

>100_bases
ATCTGCTGGATACTTTTTTTGAGCGGTGGCGGGCGCAGGGCGCGCCCATGCTGGATGACGGTGCATGCCGTGTTCAGACC
GCCCCCGCGGGAGACGATCA

Downstream 100 bases:

>100_bases
AAGGGCTGACAGCCCCGCTGCTGATTTCATCCGGAGGAAACCATGTCGCAGACAAATATCCTGCTTGAGGCGGGCACCAA
TGAACTGGAAATCGTCGAAT

Product: hydroxymethylbutenyl pyrophosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHVKRAATAGFCMGVGLALKKLDRELDNNAKDIATLGPIIHNPQVLRRYEQKGVRCYTDPAEARSGQRVVIRAHGIPEET
ESALAAAGVDLVDATCPKVKRAQLGIARQREKGRTLLLFGEHDHPEVQGLLSYAGEGAVVFGSLEELQNGPLEDDRHYFL
AAQTTQDKHAFTSVIEWVRRRFGDHVPVLDTICDATRERQDEAIAIARSVDVMVVVGGFASGNTRRLAEVAQAQGVPTYH
VETPDQLPLDAIRGYGAAGLTAGASTPKSIIDETQKLLESL

Sequences:

>Translated_281_residues
MHVKRAATAGFCMGVGLALKKLDRELDNNAKDIATLGPIIHNPQVLRRYEQKGVRCYTDPAEARSGQRVVIRAHGIPEET
ESALAAAGVDLVDATCPKVKRAQLGIARQREKGRTLLLFGEHDHPEVQGLLSYAGEGAVVFGSLEELQNGPLEDDRHYFL
AAQTTQDKHAFTSVIEWVRRRFGDHVPVLDTICDATRERQDEAIAIARSVDVMVVVGGFASGNTRRLAEVAQAQGVPTYH
VETPDQLPLDAIRGYGAAGLTAGASTPKSIIDETQKLLESL
>Mature_281_residues
MHVKRAATAGFCMGVGLALKKLDRELDNNAKDIATLGPIIHNPQVLRRYEQKGVRCYTDPAEARSGQRVVIRAHGIPEET
ESALAAAGVDLVDATCPKVKRAQLGIARQREKGRTLLLFGEHDHPEVQGLLSYAGEGAVVFGSLEELQNGPLEDDRHYFL
AAQTTQDKHAFTSVIEWVRRRFGDHVPVLDTICDATRERQDEAIAIARSVDVMVVVGGFASGNTRRLAEVAQAQGVPTYH
VETPDQLPLDAIRGYGAAGLTAGASTPKSIIDETQKLLESL

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=285, Percent_Identity=27.719298245614, Blast_Score=118, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_DESDG (Q316F5)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386886.1
- STRING:   Q316F5
- GeneID:   3756322
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0390
- NMPDR:   fig|207559.3.peg.1900
- eggNOG:   COG0761
- HOGENOM:   HBG335228
- OMA:   HMQVARA
- ProtClustDB:   CLSK704379
- BioCyc:   DDES207559:DDE_0390-MONOMER
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 30509; Mature: 30509

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVKRAATAGFCMGVGLALKKLDRELDNNAKDIATLGPIIHNPQVLRRYEQKGVRCYTDP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEECCH
AEARSGQRVVIRAHGIPEETESALAAAGVDLVDATCPKVKRAQLGIARQREKGRTLLLFG
HHHCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEC
EHDHPEVQGLLSYAGEGAVVFGSLEELQNGPLEDDRHYFLAAQTTQDKHAFTSVIEWVRR
CCCCHHHHHHHHHCCCCEEEEECHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
RFGDHVPVLDTICDATRERQDEAIAIARSVDVMVVVGGFASGNTRRLAEVAQAQGVPTYH
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEE
VETPDQLPLDAIRGYGAAGLTAGASTPKSIIDETQKLLESL
CCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHVKRAATAGFCMGVGLALKKLDRELDNNAKDIATLGPIIHNPQVLRRYEQKGVRCYTDP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEECCH
AEARSGQRVVIRAHGIPEETESALAAAGVDLVDATCPKVKRAQLGIARQREKGRTLLLFG
HHHCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEC
EHDHPEVQGLLSYAGEGAVVFGSLEELQNGPLEDDRHYFLAAQTTQDKHAFTSVIEWVRR
CCCCHHHHHHHHHCCCCEEEEECHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHH
RFGDHVPVLDTICDATRERQDEAIAIARSVDVMVVVGGFASGNTRRLAEVAQAQGVPTYH
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEE
VETPDQLPLDAIRGYGAAGLTAGASTPKSIIDETQKLLESL
CCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA