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The map label for this gene is yfhQ [H]

Identifier: 78355259

GI number: 78355259

Start: 193112

End: 194218

Strand: Direct

Name: yfhQ [H]

Synonym: Dde_0212

Alternate gene names: 78355259

Gene position: 193112-194218 (Clockwise)

Preceding gene: 78355257

Following gene: 78355262

Centisome position: 5.18

GC content: 59.44

Gene sequence:

>1107_bases
ATGATACATGATGATGATAAAGAACGGTTCGTACAGGCGCTGCTGGGCTGGTTTTCCGTGAATATGCGCGATCTGCCGTG
GCGCCGCGATTATACTCCGTACCGCGTCTGGGTATCGGAAATAATGCTGCAACAGACACAGATGGAACGGGGCGTGACCT
ACTTCAACCGCTGGATGGGGCGTTTTCCCGATGTGGCCGCCGTGGCGCGCGCTGCGGAAAACGATGTGCTGAAGGCATGG
GAAGGTCTGGGGTATTATTCACGCGCGCGTAATCTGCACAGGGCTGCCCGTCTGATAATGCAGGAGCACGGCGGGGTTTT
TCCCTGCCGGTATGAAGATATCAGGGCGTTGCCCGGTGTGGGCGACTACACCGCAGGGGCCATAGCGTCCATTGCGTTTC
AGCAGGATGCCGTGGCTGTGGACGCCAATGTGGAGCGCGTTTTTTCGCGTCTGTTCGACATTGATACTCCCATAAAGGAA
AAGGAAAACGCGGCCTTTGTGCGGCATACGGCGCAGAGCCTGCTGCCCCGCGGCAAGGCCCGCCTGTTCAATCAGGCTCT
TATGGAGCTGGGCGCGCTGGTCTGCGGAAAAAAAGCCCGCTGCCCGCTGTGTCCCGTGCAGCAGTGGTGCGAGGCGTTCC
GTCTGGGGATTGTGCAGGAACGTCCGGTGCTTACCGCCCGCAAATCCATAGTGCCTATCGAGGTGGCCACCGGCTTTCTG
GTGCATCAGGGCAGGATATTTATTCAGAAACGACCGGAAATGGGCGTATGGGCAGGATTCTGGGAGTTCCCCGGCGGTTG
CATAGAGCAGGGGGAGACTGCGGAGGAAGCCGTGCGGCGCGAGTTTATGGAAGAGACGGAGTTCGACGTTGTTCCGCGGG
AAAAGATAGCCGTGGTGCGTCATGGCTACACCACATACCGCGCCACACTGCATTGTTATCTGCTGGAACTGCGTGGCGGC
AGTGATGTGCCCGTACTGCATGCGGCTACGGAAAGCCGCTGGGTGCGTTTTGCCGAGCTGGACGGCTATACGCTGCCTGC
GGGGCACCGCAAACTTGTGGATATGATGGCCGGCAGCCTGCAGTGGCAATGGCTGCAGGGCGGCTAG

Upstream 100 bases:

>100_bases
CTTTTGCCGTCATAATAGCACATTTTCCGTGCAGCGCGAATAGCGGCGGCCTGCCCGCGGAGAGCTTTTCAAGCCTGTCC
GGTAAGGGTACAAGACCGGC

Downstream 100 bases:

>100_bases
TCCGCAGTGCCCGTTGCGCCGGAGACCCCTGCCGTGCGGGGTGTTTCAGCCTGACCTGAAGTACGGTCAGGGTCAGGCAG
GGCGCGTGTCATGTCTATGC

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MIHDDDKERFVQALLGWFSVNMRDLPWRRDYTPYRVWVSEIMLQQTQMERGVTYFNRWMGRFPDVAAVARAAENDVLKAW
EGLGYYSRARNLHRAARLIMQEHGGVFPCRYEDIRALPGVGDYTAGAIASIAFQQDAVAVDANVERVFSRLFDIDTPIKE
KENAAFVRHTAQSLLPRGKARLFNQALMELGALVCGKKARCPLCPVQQWCEAFRLGIVQERPVLTARKSIVPIEVATGFL
VHQGRIFIQKRPEMGVWAGFWEFPGGCIEQGETAEEAVRREFMEETEFDVVPREKIAVVRHGYTTYRATLHCYLLELRGG
SDVPVLHAATESRWVRFAELDGYTLPAGHRKLVDMMAGSLQWQWLQGG

Sequences:

>Translated_368_residues
MIHDDDKERFVQALLGWFSVNMRDLPWRRDYTPYRVWVSEIMLQQTQMERGVTYFNRWMGRFPDVAAVARAAENDVLKAW
EGLGYYSRARNLHRAARLIMQEHGGVFPCRYEDIRALPGVGDYTAGAIASIAFQQDAVAVDANVERVFSRLFDIDTPIKE
KENAAFVRHTAQSLLPRGKARLFNQALMELGALVCGKKARCPLCPVQQWCEAFRLGIVQERPVLTARKSIVPIEVATGFL
VHQGRIFIQKRPEMGVWAGFWEFPGGCIEQGETAEEAVRREFMEETEFDVVPREKIAVVRHGYTTYRATLHCYLLELRGG
SDVPVLHAATESRWVRFAELDGYTLPAGHRKLVDMMAGSLQWQWLQGG
>Mature_368_residues
MIHDDDKERFVQALLGWFSVNMRDLPWRRDYTPYRVWVSEIMLQQTQMERGVTYFNRWMGRFPDVAAVARAAENDVLKAW
EGLGYYSRARNLHRAARLIMQEHGGVFPCRYEDIRALPGVGDYTAGAIASIAFQQDAVAVDANVERVFSRLFDIDTPIKE
KENAAFVRHTAQSLLPRGKARLFNQALMELGALVCGKKARCPLCPVQQWCEAFRLGIVQERPVLTARKSIVPIEVATGFL
VHQGRIFIQKRPEMGVWAGFWEFPGGCIEQGETAEEAVRREFMEETEFDVVPREKIAVVRHGYTTYRATLHCYLLELRGG
SDVPVLHAATESRWVRFAELDGYTLPAGHRKLVDMMAGSLQWQWLQGG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI115298648, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI6912520, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI115298650, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI115298654, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI115298652, Length=410, Percent_Identity=31.9512195121951, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1789331, Length=305, Percent_Identity=35.0819672131148, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42025; Mature: 42025

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHDDDKERFVQALLGWFSVNMRDLPWRRDYTPYRVWVSEIMLQQTQMERGVTYFNRWMG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFPDVAAVARAAENDVLKAWEGLGYYSRARNLHRAARLIMQEHGGVFPCRYEDIRALPGV
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
GDYTAGAIASIAFQQDAVAVDANVERVFSRLFDIDTPIKEKENAAFVRHTAQSLLPRGKA
CCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHH
RLFNQALMELGALVCGKKARCPLCPVQQWCEAFRLGIVQERPVLTARKSIVPIEVATGFL
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCEEEEEHHCCEE
VHQGRIFIQKRPEMGVWAGFWEFPGGCIEQGETAEEAVRREFMEETEFDVVPREKIAVVR
EECCEEEEEECCCCCEEECHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
HGYTTYRATLHCYLLELRGGSDVPVLHAATESRWVRFAELDGYTLPAGHRKLVDMMAGSL
CCCHHHHHEEEEEEEEECCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHHHCCC
QWQWLQGG
EEEEECCC
>Mature Secondary Structure
MIHDDDKERFVQALLGWFSVNMRDLPWRRDYTPYRVWVSEIMLQQTQMERGVTYFNRWMG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFPDVAAVARAAENDVLKAWEGLGYYSRARNLHRAARLIMQEHGGVFPCRYEDIRALPGV
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCC
GDYTAGAIASIAFQQDAVAVDANVERVFSRLFDIDTPIKEKENAAFVRHTAQSLLPRGKA
CCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHH
RLFNQALMELGALVCGKKARCPLCPVQQWCEAFRLGIVQERPVLTARKSIVPIEVATGFL
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCEEEEEHHCCEE
VHQGRIFIQKRPEMGVWAGFWEFPGGCIEQGETAEEAVRREFMEETEFDVVPREKIAVVR
EECCEEEEEECCCCCEEECHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
HGYTTYRATLHCYLLELRGGSDVPVLHAATESRWVRFAELDGYTLPAGHRKLVDMMAGSL
CCCHHHHHEEEEEEEEECCCCCCCEEEECCCCCEEEEEECCCEECCCHHHHHHHHHHCCC
QWQWLQGG
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]