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The map label for this gene is dnaX [H]

Identifier: 78355113

GI number: 78355113

Start: 56972

End: 58705

Strand: Direct

Name: dnaX [H]

Synonym: Dde_0066

Alternate gene names: 78355113

Gene position: 56972-58705 (Clockwise)

Preceding gene: 78355112

Following gene: 78355114

Centisome position: 1.53

GC content: 61.82

Gene sequence:

>1734_bases
ATGAGTCACGCATCGCTAACCGCAAAATACAGGCCGCAGACCTTTGCCGACGTTGCCGGACAGGAAACCGTCAAAGCCAT
TCTGTCACGGGCCGCGGCCGAAAACAGGGTCGCGCCTGCCTACTTGTTCAGCGGTACGCGCGGGGTGGGAAAAACCACCA
TCGCGCGTATTTTTGCCAAGGCGCTTAACTGCACCCGCGGTCCGGCCGCGGAACCCTGCAACGAGTGTGAACAGTGCCGC
AAGATAACGCAGGGCATGGCTGTGGACGTGGTGGAGATTGACGGCGCCTCCAACCGCGGCATTGATGACGCCAAACGCCT
CAAGGAAGCCATCGGTTATGCCCCCATGGAGGGCCGGTACAAGGTTTTCATCATCGACGAGGCGCACATGCTCACCCGCG
AGGCGTTTAACGCGCTGCTGAAAACGCTGGAAGAGCCGCCGGCCAATGTCACCTTTGTCATGGCCACCACCGAGCCGCAT
AAATTTCCCGTAACCATTGTCAGCCGCTGTCAGCATTTTATTTTCAAACGGCTTACCGAAAACGGACTGGCAGCGCATCT
GGTGCGCATTCTTGAGCGCGAAGGCACAGGATACGAGTCTGAAGCGGTCAAGCTTATTGCCCGTCGTGCCGCCGGCAGCG
TACGCGACTCCATGTCTTTGCTGGGACAGGTGCTGGCACTGGGCAGCGATTCTCTGACCGTGGCGGATGCCCGGGGTATT
CTGGGGCTTGCCGGACAGGAGCTGTTTTTCCGCGTGGCCGACGCCATCAGGCGTCAGGACTGTGTCGGTGTTTCCACCGT
GTTGCGCGATGTTCTTGATCAGGGACTTGATCTGGGCTTTTTTTTGCGCGAGCTGACAGGCATGTGGCGCAACCTGTTCA
TGTTGCGTCAGGCCGGTGAAAGCGCATTGCCCCTGCTGGACCTGCCCGAAGAAGAAGCCCGTCAGTGGCTTGAATGGGCA
CCGCAGTTTGCCCTGTCGCACATCCATGCCTGCTGGCAGATGACTCTGGAAGGACAGCGGCGCGTGCTGAACAGCCTTGA
ACCGGCCATGGCGCTGGAACTGCTGCTGCTCAATCTTGCATTCATGCCGCGCCTGCTGGGTATGCAGCAGGTTTCGCAGA
CGGCGCCTGCTCCGGTGCCCGTGGCCGGTGACGGACCTGCTCCTTCCGGCGGTTCGTCCGGTACTCCGCCGGCGGGCGGA
CATGCTGCTCCGCCCCGCTCTGCCCCGTCTGTCCCGTCTGTCCCGGACCCTGCCGGTACTTCCGGTCGTGTTGCGGATGC
GGCGAAACCGCAACAGCAAGCGCAGGCAGACAGTACAGCGCCCCCCCCCGCCGAGGATGCTCCGCCGGGGCAGTCCGAGC
CGTCCGGCCCCGCCACGTGGGAGGGTTTCGCGCAGTTCTGCCTGCAGCAGAACGGTCAGGACGGCAAAAGCCTGCGGCTC
CTGCGGCAGATAAAAGGTGAACTGCGTGACGGGGTGCTGCATATCACCCCCGCGTACCAGATGCAGCGCGACCGTCTGAC
ACAGCCGGAAATGGCAGCCGCTCTGGAGACTCTGGCCCGCAGCTACTGGGGTGCGGGTGTTACAGTGGCGGTGGGTGAAC
CCACCGAACAGCGCAAGGCCATCTCGGACCTGCGCAAGGAACTGGATGACCACCCTGCCGTACAGCTTCTGAAAGAAGAG
TTGGGAGCGCGTGTGCTGGCGGTGCGGTATATGGAAAAAAATAACAACGACTGA

Upstream 100 bases:

>100_bases
CGCACACTGGCTGCATCAGTATTCACTGTAGCGGCATACGCCTTTCCGGCCGGCCCTGCCTCGGCAGGGCCGGTTTTTCA
CCCTTTTAGCCCCCCCACTT

Downstream 100 bases:

>100_bases
TAACGGCGCTGGCCGTATACAGACATTCCCGGAGGATCATATGAGAGGCATGCAGGATATGCTGCGTCAGGCGCAGATTA
TGCAAAAGAAGATGACCGAG

Product: DNA polymerase III subunit tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MSHASLTAKYRPQTFADVAGQETVKAILSRAAAENRVAPAYLFSGTRGVGKTTIARIFAKALNCTRGPAAEPCNECEQCR
KITQGMAVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPANVTFVMATTEPH
KFPVTIVSRCQHFIFKRLTENGLAAHLVRILEREGTGYESEAVKLIARRAAGSVRDSMSLLGQVLALGSDSLTVADARGI
LGLAGQELFFRVADAIRRQDCVGVSTVLRDVLDQGLDLGFFLRELTGMWRNLFMLRQAGESALPLLDLPEEEARQWLEWA
PQFALSHIHACWQMTLEGQRRVLNSLEPAMALELLLLNLAFMPRLLGMQQVSQTAPAPVPVAGDGPAPSGGSSGTPPAGG
HAAPPRSAPSVPSVPDPAGTSGRVADAAKPQQQAQADSTAPPPAEDAPPGQSEPSGPATWEGFAQFCLQQNGQDGKSLRL
LRQIKGELRDGVLHITPAYQMQRDRLTQPEMAAALETLARSYWGAGVTVAVGEPTEQRKAISDLRKELDDHPAVQLLKEE
LGARVLAVRYMEKNNND

Sequences:

>Translated_577_residues
MSHASLTAKYRPQTFADVAGQETVKAILSRAAAENRVAPAYLFSGTRGVGKTTIARIFAKALNCTRGPAAEPCNECEQCR
KITQGMAVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPANVTFVMATTEPH
KFPVTIVSRCQHFIFKRLTENGLAAHLVRILEREGTGYESEAVKLIARRAAGSVRDSMSLLGQVLALGSDSLTVADARGI
LGLAGQELFFRVADAIRRQDCVGVSTVLRDVLDQGLDLGFFLRELTGMWRNLFMLRQAGESALPLLDLPEEEARQWLEWA
PQFALSHIHACWQMTLEGQRRVLNSLEPAMALELLLLNLAFMPRLLGMQQVSQTAPAPVPVAGDGPAPSGGSSGTPPAGG
HAAPPRSAPSVPSVPDPAGTSGRVADAAKPQQQAQADSTAPPPAEDAPPGQSEPSGPATWEGFAQFCLQQNGQDGKSLRL
LRQIKGELRDGVLHITPAYQMQRDRLTQPEMAAALETLARSYWGAGVTVAVGEPTEQRKAISDLRKELDDHPAVQLLKEE
LGARVLAVRYMEKNNND
>Mature_576_residues
SHASLTAKYRPQTFADVAGQETVKAILSRAAAENRVAPAYLFSGTRGVGKTTIARIFAKALNCTRGPAAEPCNECEQCRK
ITQGMAVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPANVTFVMATTEPHK
FPVTIVSRCQHFIFKRLTENGLAAHLVRILEREGTGYESEAVKLIARRAAGSVRDSMSLLGQVLALGSDSLTVADARGIL
GLAGQELFFRVADAIRRQDCVGVSTVLRDVLDQGLDLGFFLRELTGMWRNLFMLRQAGESALPLLDLPEEEARQWLEWAP
QFALSHIHACWQMTLEGQRRVLNSLEPAMALELLLLNLAFMPRLLGMQQVSQTAPAPVPVAGDGPAPSGGSSGTPPAGGH
AAPPRSAPSVPSVPDPAGTSGRVADAAKPQQQAQADSTAPPPAEDAPPGQSEPSGPATWEGFAQFCLQQNGQDGKSLRLL
RQIKGELRDGVLHITPAYQMQRDRLTQPEMAAALETLARSYWGAGVTVAVGEPTEQRKAISDLRKELDDHPAVQLLKEEL
GARVLAVRYMEKNNND

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=216, Percent_Identity=27.3148148148148, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4506491, Length=277, Percent_Identity=24.5487364620939, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31881687, Length=277, Percent_Identity=24.5487364620939, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI6677723, Length=215, Percent_Identity=25.5813953488372, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI194306571, Length=218, Percent_Identity=25.2293577981651, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194306567, Length=218, Percent_Identity=25.2293577981651, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786676, Length=466, Percent_Identity=37.5536480686695, Blast_Score=269, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17554730, Length=244, Percent_Identity=26.6393442622951, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=216, Percent_Identity=26.8518518518519, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324478, Length=221, Percent_Identity=24.8868778280543, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=215, Percent_Identity=25.1162790697674, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647857, Length=223, Percent_Identity=27.3542600896861, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859927, Length=229, Percent_Identity=28.82096069869, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62414; Mature: 62283

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHASLTAKYRPQTFADVAGQETVKAILSRAAAENRVAPAYLFSGTRGVGKTTIARIFAK
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHH
ALNCTRGPAAEPCNECEQCRKITQGMAVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRY
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCE
KVFIIDEAHMLTREAFNALLKTLEEPPANVTFVMATTEPHKFPVTIVSRCQHFIFKRLTE
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NGLAAHLVRILEREGTGYESEAVKLIARRAAGSVRDSMSLLGQVLALGSDSLTVADARGI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEHHCCH
LGLAGQELFFRVADAIRRQDCVGVSTVLRDVLDQGLDLGFFLRELTGMWRNLFMLRQAGE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SALPLLDLPEEEARQWLEWAPQFALSHIHACWQMTLEGQRRVLNSLEPAMALELLLLNLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FMPRLLGMQQVSQTAPAPVPVAGDGPAPSGGSSGTPPAGGHAAPPRSAPSVPSVPDPAGT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SGRVADAAKPQQQAQADSTAPPPAEDAPPGQSEPSGPATWEGFAQFCLQQNGQDGKSLRL
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
LRQIKGELRDGVLHITPAYQMQRDRLTQPEMAAALETLARSYWGAGVTVAVGEPTEQRKA
HHHHHHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
ISDLRKELDDHPAVQLLKEELGARVLAVRYMEKNNND
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHASLTAKYRPQTFADVAGQETVKAILSRAAAENRVAPAYLFSGTRGVGKTTIARIFAK
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHH
ALNCTRGPAAEPCNECEQCRKITQGMAVDVVEIDGASNRGIDDAKRLKEAIGYAPMEGRY
HHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCE
KVFIIDEAHMLTREAFNALLKTLEEPPANVTFVMATTEPHKFPVTIVSRCQHFIFKRLTE
EEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
NGLAAHLVRILEREGTGYESEAVKLIARRAAGSVRDSMSLLGQVLALGSDSLTVADARGI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEHHCCH
LGLAGQELFFRVADAIRRQDCVGVSTVLRDVLDQGLDLGFFLRELTGMWRNLFMLRQAGE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
SALPLLDLPEEEARQWLEWAPQFALSHIHACWQMTLEGQRRVLNSLEPAMALELLLLNLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FMPRLLGMQQVSQTAPAPVPVAGDGPAPSGGSSGTPPAGGHAAPPRSAPSVPSVPDPAGT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SGRVADAAKPQQQAQADSTAPPPAEDAPPGQSEPSGPATWEGFAQFCLQQNGQDGKSLRL
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
LRQIKGELRDGVLHITPAYQMQRDRLTQPEMAAALETLARSYWGAGVTVAVGEPTEQRKA
HHHHHHHHHCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
ISDLRKELDDHPAVQLLKEELGARVLAVRYMEKNNND
HHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]