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The map label for this gene is hhoB [H]

Identifier: 78224245

GI number: 78224245

Start: 3446349

End: 3448667

Strand: Reverse

Name: hhoB [H]

Synonym: Gmet_3052

Alternate gene names: 78224245

Gene position: 3448667-3446349 (Counterclockwise)

Preceding gene: 78224246

Following gene: 78224238

Centisome position: 86.27

GC content: 42.52

Gene sequence:

>2319_bases
ATGCGGTTAATTACAAATCTTCTAATTATTGCAATTCTTTTTTCAGTTCCTCATGTTTCCATCGCCAGAATACCCGAGGT
TGTTCTTTCCAAGAAGTCCGCAGTCGTTTCCATTTACGTTGAAGATAAACAAAAGATAGTCGCTGGTGGCAGTGGGTTCA
TCATTGACCAGAACGGTATCATTGTTACAAATGCCCACGTCATAGAGCCATGGAATAAGAGTACTACTGGCATTCTGTAT
GTTAAAAAATCCGATGGCACTTTCCTTGAGCCGACTGAGGTCATCGCTGCAGATGCGGTTAAGGATGTTGCCCTGGTTCG
AGTTAAGGAACAGAACCTGCCTTTTATTAAGCTGACATCGAACATTACGCCCACTCAAGGTGATGATGTCGTAGTTATCG
GGAACCCCCTTGGTCTGGAGACAACGGTTACTGATGGTATTATCAGCGCCATCAGAGGGGAAGATGGTTTCCTGCAAATT
TCAGCGCCCATCTCACAGGGGAGTAGTGGCAGTCCAGTGCTGAACAGCAAGGGGGAGGCGATAGGGGTTGCCACCTCGAT
TATGGCAGGTGGCCAGAACCTAAATTTTGCCATACCAGCGAGCTACGTCACTAATCTTCCCACTCAGGAGAAAGCGCCCC
CTGTGAAGGGGCTTAAAAAGAGAGCAGAGTCACCTTCCGGCTTTGAGACAGTAACCCCGGAGGATATCGAGCGGGACGTT
GTTCAGATACCGGAAGGGGCTGTTCACAAGGGCAAGGTCTTATTTGCGACAGACAGTGGTGGCTACACGTACATAAGAAT
TGAGGAGAATGGTGCACCATTATGGGTTGCCGTCACGCAAACCACTATTTCCATCGGTGACATAATCGAATTTCCTGACA
GCCCTCCGATGACTGGATTCAATTCAAAATCTATGAACATGACTTTCGACAAGATAACATTTGCAGCCGGTATACGGATT
GTCCAACGGGGAAATGTTGAATTTAAATCTCCCGAAGAGAAGCATCTTTATTATGCTGAGCAGTATTCTTCTATGAATAA
CACTCCAGCAGCGATTGAGGAAATTTCCAAAGCAATCGAGTTGAACCCGAAGAAGGCTGAATATTACGGGAAAAGAGCTA
ATTACTATCTGCAGCGAAGAATGTATGCAGATAGCAAATCAGATGAATATCAGCAAATCGTGGCATCGAACAGAGAATCG
TGCCGTAACGCGGTTGATGATCTGAACAAGGCTATCGCCATAAACCCAGGCAATGATGTGTTTTATGCAACACAGGCCCG
TATTTTCACAGATTCACTATTTTGCGACTATGCCAATGCTGACAAGGCAATAAAACTCTATGAAACAGCAATACAGCTGA
ATCCGAAGAAAGCGGATTATTATGTTGAAAAGGGGTGGCAGCATAAGATAAAAAATGATTTTAGCAAGGTTCTGGATTGT
GCTAAAAAAGCGCTTTCAATCAGCCCTAATAATGAAGATGCACACTATTTGTATGGTTCGTATTATGAAGAAAACAACAA
GTACGATAAAGCCCTTGAGTATTATACGAAAGGTTTGTCTGTAAGCGACAACGTCACTTTTGGTTATTTTTATATAGACG
GTGTAATGGAAAAGACCAAGAAATATGATGATGCCGTCAGGATATATACTGACCTCATCAAACAACATCCTAAACGTTTG
ATATTTTATAACGGCAGGGCGGAGTATTACGCCAAATTGAAAAATTACAAGAAGGCTATTGCAGACTATACGACTTGCAT
CAAGCTAAATCCAAATTCCGAATATAATTACAACCTGAGAGCAAACTGTTATTACGAAGACGGAAAGAAATCCGAAGCAT
TGACCGACTATCGAACTGCTTGCGATATGAAGCACGCTGAATCATGCGAGATGATTCCAATTGTATTTGCCGATATCAAG
CGTGGCGCTAATTGGGTACCAGTGGCAGCAAGCAGCGATGTAAATTATTATTACGACAAGAAGGGATATACAAAAAATAA
GAACGGAGTTGCTGTTGCCTGGATTCGCGGGGAAATAACTGACAAGGAAGAATATATCAAGGATATCGATATCAGCGAAT
ACGAAAAGGAAAAATACAAAAATGTGTCACATGTTATGAGCAGGTTTGAAGTCGATTGCCCAAATCAAAAATTGAGAGTG
CCGATTTCACTGATTTATGCTGAAAACGGCAACGTTATCAGGTCGTATGAAGATGAAAAAACAAAATACAGCAATATTAT
TCCCAATTCAATCGGTGCGAGCATTCACGAGAATCTGTGTAAAGGCGCCCCAGCAAAAAAGATAGGGAAAAAGAAATAA

Upstream 100 bases:

>100_bases
CGGCTCGTTCATCATCTTGATTTTGTTGCTAACGATTGTATGGTTGTTAGGCTAATAAATTGAAATGTCGATGAAATCCA
GCCTTTAAATGGAGGGCTTT

Downstream 100 bases:

>100_bases
TATATCACTAGTGTCCTGTTTGGTTAGTCGGGTCTACTAATGTTGCTCTAGAATCATTATCTTTGAGTACAGCAATAAAT
GACACCAGATCATGATGAGG

Product: peptidase S1C, HrtA/DegP2/Q/S

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 772

Protein sequence:

>772_residues
MRLITNLLIIAILFSVPHVSIARIPEVVLSKKSAVVSIYVEDKQKIVAGGSGFIIDQNGIIVTNAHVIEPWNKSTTGILY
VKKSDGTFLEPTEVIAADAVKDVALVRVKEQNLPFIKLTSNITPTQGDDVVVIGNPLGLETTVTDGIISAIRGEDGFLQI
SAPISQGSSGSPVLNSKGEAIGVATSIMAGGQNLNFAIPASYVTNLPTQEKAPPVKGLKKRAESPSGFETVTPEDIERDV
VQIPEGAVHKGKVLFATDSGGYTYIRIEENGAPLWVAVTQTTISIGDIIEFPDSPPMTGFNSKSMNMTFDKITFAAGIRI
VQRGNVEFKSPEEKHLYYAEQYSSMNNTPAAIEEISKAIELNPKKAEYYGKRANYYLQRRMYADSKSDEYQQIVASNRES
CRNAVDDLNKAIAINPGNDVFYATQARIFTDSLFCDYANADKAIKLYETAIQLNPKKADYYVEKGWQHKIKNDFSKVLDC
AKKALSISPNNEDAHYLYGSYYEENNKYDKALEYYTKGLSVSDNVTFGYFYIDGVMEKTKKYDDAVRIYTDLIKQHPKRL
IFYNGRAEYYAKLKNYKKAIADYTTCIKLNPNSEYNYNLRANCYYEDGKKSEALTDYRTACDMKHAESCEMIPIVFADIK
RGANWVPVAASSDVNYYYDKKGYTKNKNGVAVAWIRGEITDKEEYIKDIDISEYEKEKYKNVSHVMSRFEVDCPNQKLRV
PISLIYAENGNVIRSYEDEKTKYSNIIPNSIGASIHENLCKGAPAKKIGKKK

Sequences:

>Translated_772_residues
MRLITNLLIIAILFSVPHVSIARIPEVVLSKKSAVVSIYVEDKQKIVAGGSGFIIDQNGIIVTNAHVIEPWNKSTTGILY
VKKSDGTFLEPTEVIAADAVKDVALVRVKEQNLPFIKLTSNITPTQGDDVVVIGNPLGLETTVTDGIISAIRGEDGFLQI
SAPISQGSSGSPVLNSKGEAIGVATSIMAGGQNLNFAIPASYVTNLPTQEKAPPVKGLKKRAESPSGFETVTPEDIERDV
VQIPEGAVHKGKVLFATDSGGYTYIRIEENGAPLWVAVTQTTISIGDIIEFPDSPPMTGFNSKSMNMTFDKITFAAGIRI
VQRGNVEFKSPEEKHLYYAEQYSSMNNTPAAIEEISKAIELNPKKAEYYGKRANYYLQRRMYADSKSDEYQQIVASNRES
CRNAVDDLNKAIAINPGNDVFYATQARIFTDSLFCDYANADKAIKLYETAIQLNPKKADYYVEKGWQHKIKNDFSKVLDC
AKKALSISPNNEDAHYLYGSYYEENNKYDKALEYYTKGLSVSDNVTFGYFYIDGVMEKTKKYDDAVRIYTDLIKQHPKRL
IFYNGRAEYYAKLKNYKKAIADYTTCIKLNPNSEYNYNLRANCYYEDGKKSEALTDYRTACDMKHAESCEMIPIVFADIK
RGANWVPVAASSDVNYYYDKKGYTKNKNGVAVAWIRGEITDKEEYIKDIDISEYEKEKYKNVSHVMSRFEVDCPNQKLRV
PISLIYAENGNVIRSYEDEKTKYSNIIPNSIGASIHENLCKGAPAKKIGKKK
>Mature_772_residues
MRLITNLLIIAILFSVPHVSIARIPEVVLSKKSAVVSIYVEDKQKIVAGGSGFIIDQNGIIVTNAHVIEPWNKSTTGILY
VKKSDGTFLEPTEVIAADAVKDVALVRVKEQNLPFIKLTSNITPTQGDDVVVIGNPLGLETTVTDGIISAIRGEDGFLQI
SAPISQGSSGSPVLNSKGEAIGVATSIMAGGQNLNFAIPASYVTNLPTQEKAPPVKGLKKRAESPSGFETVTPEDIERDV
VQIPEGAVHKGKVLFATDSGGYTYIRIEENGAPLWVAVTQTTISIGDIIEFPDSPPMTGFNSKSMNMTFDKITFAAGIRI
VQRGNVEFKSPEEKHLYYAEQYSSMNNTPAAIEEISKAIELNPKKAEYYGKRANYYLQRRMYADSKSDEYQQIVASNRES
CRNAVDDLNKAIAINPGNDVFYATQARIFTDSLFCDYANADKAIKLYETAIQLNPKKADYYVEKGWQHKIKNDFSKVLDC
AKKALSISPNNEDAHYLYGSYYEENNKYDKALEYYTKGLSVSDNVTFGYFYIDGVMEKTKKYDDAVRIYTDLIKQHPKRL
IFYNGRAEYYAKLKNYKKAIADYTTCIKLNPNSEYNYNLRANCYYEDGKKSEALTDYRTACDMKHAESCEMIPIVFADIK
RGANWVPVAASSDVNYYYDKKGYTKNKNGVAVAWIRGEITDKEEYIKDIDISEYEKEKYKNVSHVMSRFEVDCPNQKLRV
PISLIYAENGNVIRSYEDEKTKYSNIIPNSIGASIHENLCKGAPAKKIGKKK

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=182, Percent_Identity=34.0659340659341, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI22129776, Length=227, Percent_Identity=32.15859030837, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI7019477, Length=194, Percent_Identity=32.4742268041237, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI32307150, Length=274, Percent_Identity=22.2627737226277, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI32307148, Length=274, Percent_Identity=22.2627737226277, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI24308541, Length=167, Percent_Identity=34.1317365269461, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786356, Length=178, Percent_Identity=38.2022471910112, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1789630, Length=144, Percent_Identity=37.5, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1789629, Length=172, Percent_Identity=34.3023255813954, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646839, Length=200, Percent_Identity=40, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647755, Length=274, Percent_Identity=22.992700729927, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585827, Length=274, Percent_Identity=22.992700729927, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585829, Length=274, Percent_Identity=22.992700729927, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 86291; Mature: 86291

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION L=RR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLITNLLIIAILFSVPHVSIARIPEVVLSKKSAVVSIYVEDKQKIVAGGSGFIIDQNGI
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCEEEEECCCEEEEECCCE
IVTNAHVIEPWNKSTTGILYVKKSDGTFLEPTEVIAADAVKDVALVRVKEQNLPFIKLTS
EEECCEEECCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHEEEEEEECCCCCEEEEEC
NITPTQGDDVVVIGNPLGLETTVTDGIISAIRGEDGFLQISAPISQGSSGSPVLNSKGEA
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCE
IGVATSIMAGGQNLNFAIPASYVTNLPTQEKAPPVKGLKKRAESPSGFETVTPEDIERDV
EEEEHHHHCCCCCCEEEECHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHH
VQIPEGAVHKGKVLFATDSGGYTYIRIEENGAPLWVAVTQTTISIGDIIEFPDSPPMTGF
HHCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEEEEECCEEECCCCCCCCCC
NSKSMNMTFDKITFAAGIRIVQRGNVEFKSPEEKHLYYAEQYSSMNNTPAAIEEISKAIE
CCCCCCEEHHHHHHHHCEEEEEECCCCCCCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHC
LNPKKAEYYGKRANYYLQRRMYADSKSDEYQQIVASNRESCRNAVDDLNKAIAINPGNDV
CCCCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCE
FYATQARIFTDSLFCDYANADKAIKLYETAIQLNPKKADYYVEKGWQHKIKNDFSKVLDC
EEEEEEEEEEHHHEEECCCCCCEEEEEEEHEEECCCCCCHHHHCCHHHHHHHHHHHHHHH
AKKALSISPNNEDAHYLYGSYYEENNKYDKALEYYTKGLSVSDNVTFGYFYIDGVMEKTK
HHHHEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHH
KYDDAVRIYTDLIKQHPKRLIFYNGRAEYYAKLKNYKKAIADYTTCIKLNPNSEYNYNLR
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEE
ANCYYEDGKKSEALTDYRTACDMKHAESCEMIPIVFADIKRGANWVPVAASSDVNYYYDK
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCEEECC
KGYTKNKNGVAVAWIRGEITDKEEYIKDIDISEYEKEKYKNVSHVMSRFEVDCPNQKLRV
CCCCCCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
PISLIYAENGNVIRSYEDEKTKYSNIIPNSIGASIHENLCKGAPAKKIGKKK
EEEEEEECCCCEEECCCCCHHHHHCCCCCHHCHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure
MRLITNLLIIAILFSVPHVSIARIPEVVLSKKSAVVSIYVEDKQKIVAGGSGFIIDQNGI
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCEEEEECCCEEEEECCCE
IVTNAHVIEPWNKSTTGILYVKKSDGTFLEPTEVIAADAVKDVALVRVKEQNLPFIKLTS
EEECCEEECCCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHEEEEEEECCCCCEEEEEC
NITPTQGDDVVVIGNPLGLETTVTDGIISAIRGEDGFLQISAPISQGSSGSPVLNSKGEA
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCE
IGVATSIMAGGQNLNFAIPASYVTNLPTQEKAPPVKGLKKRAESPSGFETVTPEDIERDV
EEEEHHHHCCCCCCEEEECHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHH
VQIPEGAVHKGKVLFATDSGGYTYIRIEENGAPLWVAVTQTTISIGDIIEFPDSPPMTGF
HHCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEEEEECCEEECCCCCCCCCC
NSKSMNMTFDKITFAAGIRIVQRGNVEFKSPEEKHLYYAEQYSSMNNTPAAIEEISKAIE
CCCCCCEEHHHHHHHHCEEEEEECCCCCCCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHC
LNPKKAEYYGKRANYYLQRRMYADSKSDEYQQIVASNRESCRNAVDDLNKAIAINPGNDV
CCCCHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCE
FYATQARIFTDSLFCDYANADKAIKLYETAIQLNPKKADYYVEKGWQHKIKNDFSKVLDC
EEEEEEEEEEHHHEEECCCCCCEEEEEEEHEEECCCCCCHHHHCCHHHHHHHHHHHHHHH
AKKALSISPNNEDAHYLYGSYYEENNKYDKALEYYTKGLSVSDNVTFGYFYIDGVMEKTK
HHHHEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHH
KYDDAVRIYTDLIKQHPKRLIFYNGRAEYYAKLKNYKKAIADYTTCIKLNPNSEYNYNLR
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEE
ANCYYEDGKKSEALTDYRTACDMKHAESCEMIPIVFADIKRGANWVPVAASSDVNYYYDK
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCEEECC
KGYTKNKNGVAVAWIRGEITDKEEYIKDIDISEYEKEKYKNVSHVMSRFEVDCPNQKLRV
CCCCCCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
PISLIYAENGNVIRSYEDEKTKYSNIIPNSIGASIHENLCKGAPAKKIGKKK
EEEEEEECCCCEEECCCCCHHHHHCCCCCHHCHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]