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The map label for this gene is atoC [H]

Identifier: 78222609

GI number: 78222609

Start: 1565515

End: 1566891

Strand: Direct

Name: atoC [H]

Synonym: Gmet_1397

Alternate gene names: 78222609

Gene position: 1565515-1566891 (Clockwise)

Preceding gene: 78222608

Following gene: 78222610

Centisome position: 39.16

GC content: 61.22

Gene sequence:

>1377_bases
ATGGAAATACGAATACTGGTTGTCGATGACGAGTTGAGCATGCGGGAATTCCTCGCCATTCTCCTCAAACGCGAGGGGTA
CGCGGTGGATCAGGCCGATTGCGCGGAAAAGGCCCTGGAGTTCCTTGACTCAATTACCTACGATCTGGTCATTTCCGATG
TGAAAATGCCCGGTCTGGACGGCATTGCCCTGCTGGGGCGGATCAAGGAAAACTCTCCCGACACCGCGGTCCTCATGATG
ACCGCCTTCTCCACCGCCGAGCAGGCCGTGGAGGCCATGAAGCTGGGGGCCTACGACTACATCGCCAAGCCCTTCAAGGT
GGAGGAGGTGAAGGTCCTCGTCCGTAACGCCCTTGAGAAGCGGGACCTGAAGCGGGAAAACCAGCGTCTGCGCCAGGAGG
TCCAGGAGCGGTACGGCTTCAGCGGCTTGATCGGCAAGAGCAAGAAGATGCGGGAACTCTACTCCCTCATCGAGCGGGTG
GCCCCCAGCATCGCCAACGTCCTGATTCTGGGTGAGAGTGGCACCGGCAAGGAACTGGTGGCACGGGCCATCCACTACAA
CAGCCCCCGCAAGGACAAGGCCTTCGTGGCGGTGAACTGCGGCGCCATTCCCGAAACACTCATGGAGAGCGAACTCTTCG
GCCACAAGAAGGGCTCCTTCACCGGCGCCATCAACGACCGGGCCGGCCTCTTCGAGCAGGCCGGCGGCGGCACCCTCTTC
CTCGACGAGATCGGCGAAGTGCCGCTCCAACTTCAGGCAAAGCTCCTGCGGGTCCTCCAGGAAAAGGAGTTCAGGCGGGT
AGGGGGAGTAGCCGACCAGAAGGCCGACGTGCGGATCGTTGCCGCCTCCAACCGCAACCTGGAAGAGCAGGTGCGGGAAG
GCTCCTTCCGGGAAGACCTCTTCTACCGGCTGAACGTGGTCCAGCTCCAGATGCCTCCCCTGCGGGAGCGGACAGAAGAC
ATCCCCCTGCTGGTGGAGCATTTTTACCGCAAGTACGTTCAGTCCAACCGCAACGGAGAGATTATCACCCCTGGCGCCCT
GAAGATTCTCATGTCATATCCGTTTCCGGGAAATGTGCGCGAACTGGAGAACCTGGTGGAACGGTGCATGGTTCTTGGCG
GGGGGACCATTTCCGAGGAGAGCCTTCCGCCCCAGGTCCGGGGGAGCCAGAAGTCCGCGACGGCCCCGGTCGGTGATTTC
GAGATTCCTTCCGAAGGGATGGACCTGGAAGGGTACCTGGACGGCATCGAGAAGAGGATCCTCCTCCAGGCCCTGGAGCG
GTGCGGCGGGGTCAAGAAGAAAGCAGCCGAGCTTCTGGGGCTCACGTTCCGGTCATTCCGCTACCGTCTGGCCAAGTTCG
GGATGGATGAGGAATGA

Upstream 100 bases:

>100_bases
GGAACCGGAACCATATTCATCATATTTATTCCCGTCCAGAGAAATTACTGAGCAGCAAAGACTCGTTCAATAGCCCATCT
AACCGTCAGGGAGAGACGTC

Downstream 100 bases:

>100_bases
TTTTTGCCTCGTCCGCAGAATCTGTGGGTAGTTGGCTGAAAAAATAAGGGCATTGCCCCTCCGTGAAGGATAAGATTGTT
TTTGCGAGAAACGATCAAGT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLDGIALLGRIKENSPDTAVLMM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEKRDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERV
APSIANVLILGESGTGKELVARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLF
LDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDLFYRLNVVQLQMPPLRERTED
IPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVRELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDF
EIPSEGMDLEGYLDGIEKRILLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE

Sequences:

>Translated_458_residues
MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLDGIALLGRIKENSPDTAVLMM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEKRDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERV
APSIANVLILGESGTGKELVARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLF
LDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDLFYRLNVVQLQMPPLRERTED
IPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVRELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDF
EIPSEGMDLEGYLDGIEKRILLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE
>Mature_458_residues
MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLDGIALLGRIKENSPDTAVLMM
TAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEKRDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERV
APSIANVLILGESGTGKELVARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLF
LDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDLFYRLNVVQLQMPPLRERTED
IPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVRELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDF
EIPSEGMDLEGYLDGIEKRILLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=45.7516339869281, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=45.2538631346578, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=42.0042643923241, Blast_Score=340, Evalue=9e-95,
Organism=Escherichia coli, GI1788905, Length=391, Percent_Identity=41.4322250639386, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI87082117, Length=349, Percent_Identity=44.1260744985673, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=44.8275862068966, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1789087, Length=362, Percent_Identity=42.5414364640884, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082152, Length=237, Percent_Identity=53.5864978902954, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786524, Length=346, Percent_Identity=41.907514450867, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=41.0658307210031, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787583, Length=330, Percent_Identity=37.8787878787879, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789828, Length=262, Percent_Identity=35.1145038167939, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI87081858, Length=320, Percent_Identity=27.5, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=108, Percent_Identity=35.1851851851852, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790552, Length=126, Percent_Identity=31.7460317460317, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789402, Length=130, Percent_Identity=33.0769230769231, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=31.3559322033898, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=30.5084745762712, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=32.7868852459016, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790863, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=107, Percent_Identity=40.1869158878505, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787229, Length=142, Percent_Identity=28.169014084507, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788394, Length=126, Percent_Identity=30.952380952381, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51273; Mature: 51273

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLD
CEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
GIALLGRIKENSPDTAVLMMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEK
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
RDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERVAPSIANVLILGESGTGKELV
HHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHH
ARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLF
HHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHCCCCEEE
LDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHH
FYRLNVVQLQMPPLRERTEDIPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVR
HHHEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHEECCCCCCHH
ELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDFEIPSEGMDLEGYLDGIEKRI
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLD
CEEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCC
GIALLGRIKENSPDTAVLMMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEK
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
RDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERVAPSIANVLILGESGTGKELV
HHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHH
ARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLF
HHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHCCCCEEE
LDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHH
FYRLNVVQLQMPPLRERTEDIPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVR
HHHEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHEECCCCCCHH
ELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDFEIPSEGMDLEGYLDGIEKRI
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]