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The map label for this gene is malR [H]

Identifier: 78222590

GI number: 78222590

Start: 1541771

End: 1542430

Strand: Reverse

Name: malR [H]

Synonym: Gmet_1378

Alternate gene names: 78222590

Gene position: 1542430-1541771 (Counterclockwise)

Preceding gene: 78222591

Following gene: 78222589

Centisome position: 38.59

GC content: 54.7

Gene sequence:

>660_bases
ATGAATGTCACCGCCTTGCAACAGATGACGGTGCTCTTTGTGGACGACGAGGAGATTGCACGGGAGCAGATGAAGATGGT
CCTGAGCAGTTTCTGCAAAAACACAATCTGTGTAGGTAGCGCCGACCAGGCCCTGGCCGCGCTGCAGGAGCATCACCCGG
ATATAGTGCTCACCGACATCCGCATGCCCGGCTTGTCAGGCATAGAGCTCCTCAATGCCGTAAAGCAGAAGGATGCGTCG
GTCGCCGTCGTCATAGTATCTGCCCATTCTGAGTCGGAATACCTGCTGGATGCGTTTCGCTACAAGGCGGACGGCTACCT
TCTGAAACCGTTCAACTTCCACGAAATGCTCGAACTCCTGTCCGACATAGCCACCCAGAAGGAAGCCGCCAGTAGTGAGC
GGAAACAGGGGCCTGACAATAGGGATTTCCTCTTGAAAATTCTCGATACACTCGGCGGAAGACGGGCCGAGATCATGGAG
TACGTCATCAATCACCTCGATGCCGACAACCTGTTCCATGGCACCTATGACGAGGTGGCTGAGGCACTCAGCGCCAGCAA
GCCGACCGTCGTAGCGACGTTTCAGATTATGCTGGAAAAGAACGTGCTGACCCGGCTCAAGTATGGAACATACCGGATGA
ACGTGGATGCTACTATCTGA

Upstream 100 bases:

>100_bases
TCTGGGCGGAGAACAGGTCCTTTGAACTGCACGGGGAAACGCACTATGGCGCCCGCATCTGCCTGCAGTTCGCCAGAACA
ACCGAGGGAGGTAAACAGAT

Downstream 100 bases:

>100_bases
TTCGCTGGTGCAATAAACAAGGCAAGAGCCTTATAGATATACGGATTTCAGGAAGCGCCCCCTGCAATAATCACCTGTTC
GTGGTTGATTTTTGCGGGGG

Product: response regulator receiver domain-containing protein

Products: NADP; 2 glutathione [C]

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDIRMPGLSGIELLNAVKQKDAS
VAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELLSDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIME
YVINHLDADNLFHGTYDEVAEALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI

Sequences:

>Translated_219_residues
MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDIRMPGLSGIELLNAVKQKDAS
VAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELLSDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIME
YVINHLDADNLFHGTYDEVAEALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI
>Mature_219_residues
MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDIRMPGLSGIELLNAVKQKDAS
VAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELLSDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIME
YVINHLDADNLFHGTYDEVAEALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=199, Percent_Identity=28.643216080402, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=32.520325203252, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24472; Mature: 24472

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDI
CCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCCEEEEEC
RMPGLSGIELLNAVKQKDASVAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELL
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHH
SDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIMEYVINHLDADNLFHGTYDEVA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
EALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure
MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDI
CCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCCEEEEEC
RMPGLSGIELLNAVKQKDASVAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELL
CCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHH
SDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIMEYVINHLDADNLFHGTYDEVA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
EALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]