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The map label for this gene is ilvC

Identifier: 78222476

GI number: 78222476

Start: 1422446

End: 1423462

Strand: Direct

Name: ilvC

Synonym: Gmet_1262

Alternate gene names: 78222476

Gene position: 1422446-1423462 (Clockwise)

Preceding gene: 78222475

Following gene: 78222477

Centisome position: 35.58

GC content: 57.72

Gene sequence:

>1017_bases
ATGAAGATTTACTATGACAAAGACTGCAATATGGGCGTACTCAAAGGGAAAAAGGTTGCCATCATCGGCTACGGCTCCCA
GGGACATGCCCATGCTAATAATCTGAAGGATTCGGGCATCGATGTTGTGGTAGGGCTCCGTGCGGATTCCGCTTCGGTCA
AGAAGGCCACCGAGGCCGGCCTGACCGTGCTCCCCACTTCTGAAGCGGTTAAGATCGCCGATGTGGTGATGATTCTCCTC
CCTGATGAAACCCAGGGGGATATCTACCGGGAGGAGATCGGCCCGTTCCTCAAACAGGGTGCCTATCTCGCCTTCAGCCA
TGGTTTCAATATCCACTTTGGCCAGATCGTGCCGCGGCCCGATGTGAACGTCATTATGATCGCTCCCAAGGGTCCGGGCC
ACCTGGTTCGCCATGAGTATACAAAGGGGGGCGGCGTGCCGAGCCTCATCGCCATCCACCACGACCCTGCCGGCAATTCC
CGCGACGTGGCCCTTGCCTATGCCTCGGCCAACGGTGGTGGTCGCGCCGGCATCATTGAGACCTCGTTCAAGGAAGAGAC
CGAGACCGACCTCTTCGGTGAGCAGGCTGTGCTGTGCGGCGGTATCTCTGCCCTGATCCAGGCTGGTTTCGAGACCCTGG
TCGAAGCAGGCTATGCGCCGGAGATGGCCTACTTCGAGTGTCTTCACGAGACGAAGCTCATCGTTGACCTGATCTACGAA
GGCGGCATCGCCAACATGCGCTACTCCATCTCCAATACTGCCGAGTATGGTGACCTCACCCGCGGGCCGCGGGTCGTTAC
CGACGAAACCAAGAAGGAGATGAAGAGGATTCTTGATGAGATCCAGACCGGCCAGTTCGCCAAGGAGTGGATGCTCGAGA
ACAAAGCCAATAAGCCGGTATTCACCGCCCTGCGCCGTAAGGGGGCCGAGCACCAGATCGAGGAAGTCGGCGCTCGTCTC
CGTTCCATGATGTCCTGGATCGGTGCTTCCAAGATCGTCGATAAAGCGAAGAACTAA

Upstream 100 bases:

>100_bases
GCCATAGGCCGCGGTGCCAAGGCGTTGAAGGGTTAGTATGTTTTTTCCGTGCCTGGCAATACAACGTAATAATTGATTCA
CTACACTCGAGGAGGAAAGA

Downstream 100 bases:

>100_bases
CAATAGACTGAACCAGAGACAGGGAGGCCGGGTACAGGAGAGGGGAAAAGGACCCAAACCGTATCCGGTCTCTTTGTGGT
TTGCGCGAAAAATGCGGTCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAGLTVLPTSEAVKIADVVMILL
PDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRPDVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNS
RDVALAYASANGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPVFTALRRKGAEHQIEEVGARL
RSMMSWIGASKIVDKAKN

Sequences:

>Translated_338_residues
MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAGLTVLPTSEAVKIADVVMILL
PDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRPDVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNS
RDVALAYASANGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPVFTALRRKGAEHQIEEVGARL
RSMMSWIGASKIVDKAKN
>Mature_338_residues
MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAGLTVLPTSEAVKIADVVMILL
PDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRPDVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNS
RDVALAYASANGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPVFTALRRKGAEHQIEEVGARL
RSMMSWIGASKIVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=40.0684931506849, Blast_Score=177, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6323387, Length=261, Percent_Identity=36.3984674329502, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_GEOMG (Q39W76)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384223.1
- HSSP:   P05793
- ProteinModelPortal:   Q39W76
- SMR:   Q39W76
- STRING:   Q39W76
- GeneID:   3739761
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1262
- NMPDR:   fig|269799.3.peg.1940
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q39W76
- ProtClustDB:   PRK05479
- BioCyc:   GMET269799:GMET_1262-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36709; Mature: 36709

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAG
CEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCC
LTVLPTSEAVKIADVVMILLPDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRP
EEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCC
DVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNSRDVALAYASANGGGRAGIIE
CCCEEEEECCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEE
TSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPV
CCCCEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
FTALRRKGAEHQIEEVGARLRSMMSWIGASKIVDKAKN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAG
CEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCC
LTVLPTSEAVKIADVVMILLPDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRP
EEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCC
DVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNSRDVALAYASANGGGRAGIIE
CCCEEEEECCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEE
TSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPV
CCCCEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
FTALRRKGAEHQIEEVGARLRSMMSWIGASKIVDKAKN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA