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The map label for this gene is uppS [H]

Identifier: 78222468

GI number: 78222468

Start: 1413689

End: 1414429

Strand: Direct

Name: uppS [H]

Synonym: Gmet_1254

Alternate gene names: 78222468

Gene position: 1413689-1414429 (Clockwise)

Preceding gene: 78222467

Following gene: 78222469

Centisome position: 35.37

GC content: 56.95

Gene sequence:

>741_bases
ATGTACGGTCTCTCACACGACAAACTTCCCCGCCACTTGGCCGTCATTATGGACGGAAACGGCCGTTGGGCCCAGGAGCG
GATGCTCAAGAGGATCATTGGCCACCAGAAGGGGGTCGAGACGGTGCGGGTGATTGTTGAGGAGTGTTCCCGTCTTGGCA
TCAAGTATCTGACACTCTTTGCCTTTTCCGCGGAGAACTGGCTCCGACCCAAGACGGAAGTGAAAGCCCTCATGTCACTT
CTCAAGAAGTACATCAGGGTCGAAACAGCACGGATGCTTGACAGCAATATACGGTTCAACGTGATCGGTGCCCGGGAGGA
ACTGCCGCCGGACGTGAACCAGGCTGTGCAGGAGGCCATCGACAGGACAGCGCGCAATACAGGTATGGTGCTGACGCTTG
CCCTTTCCTACGGTGCACGCCAGGAAATTCTCTTGGCGGCCGAGCGCATTGCTGCCGACCTCTCCTCAGGCCATCTCTCC
CTTGGCGATATTGACGAGAAAACCTTCTCCTCATACCTGTTTACGTCTGGCATGCCCGATCCCGATTTCCTCATCAGAAC
GAGCGGGGAGATGCGGATCAGTAATTTCCTCCTCTGGCAACTCGCTTACACAGAGCTCTATTTTACCGAGGTCAACTGGC
CCGAGTTCACCGCTAAGGAGCTCCACCGTGCTCTGCACGACTATCAGTCCCGCGAGCGGCGCTTCGGCCGTACGAGTGCG
CAACTGCAGAACAGGAGCTGA

Upstream 100 bases:

>100_bases
AAAAGTATTTTTCCGCTTTTTGCTTGCGCACCAAGTGCTTTTATGCTTTAATCCCCTTTAACCCCTCAATTAAAGGGGAT
TTTTTGTTTCTGGGTATCCC

Downstream 100 bases:

>100_bases
CCATCAAGCGTCTACTGACCGGGGTCATTGCCCTGCCTCTGTTGATATTGTTCATCCTTAAAGCGAGCGTTTTCGTCTTT
GCCTGCTTTGTTGGTCTCCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLFAFSAENWLRPKTEVKALMSL
LKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAIDRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLS
LGDIDEKTFSSYLFTSGMPDPDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSA
QLQNRS

Sequences:

>Translated_246_residues
MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLFAFSAENWLRPKTEVKALMSL
LKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAIDRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLS
LGDIDEKTFSSYLFTSGMPDPDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSA
QLQNRS
>Mature_246_residues
MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLFAFSAENWLRPKTEVKALMSL
LKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAIDRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLS
LGDIDEKTFSSYLFTSGMPDPDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSA
QLQNRS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=36.6071428571429, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=36.6071428571429, Blast_Score=150, Evalue=8e-37,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=41.5254237288136, Blast_Score=194, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.9557522123894, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=35.6807511737089, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=30.7339449541284, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=38.8392857142857, Blast_Score=156, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28254; Mature: 28254

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLF
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AFSAENWLRPKTEVKALMSLLKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAI
HCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHHHH
DRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLSLGDIDEKTFSSYLFTSGMPD
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
PDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSA
CCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
QLQNRS
HHCCCC
>Mature Secondary Structure
MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLF
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
AFSAENWLRPKTEVKALMSLLKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAI
HCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHHHH
DRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLSLGDIDEKTFSSYLFTSGMPD
HHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
PDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSA
CCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
QLQNRS
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA