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The map label for this gene is pyrH

Identifier: 78222466

GI number: 78222466

Start: 1412292

End: 1413011

Strand: Direct

Name: pyrH

Synonym: Gmet_1252

Alternate gene names: 78222466

Gene position: 1412292-1413011 (Clockwise)

Preceding gene: 78222465

Following gene: 78222467

Centisome position: 35.33

GC content: 55.69

Gene sequence:

>720_bases
ATGGGAACACCGTACTACAAGCGAGTATTATTGAAACTTTCCGGCGAGGCCCTTGCGGGCGACCAGGGCTACGGCATCGA
TCCTCTGACGATCACGACCATTGCCGCCGAGATCAAAGAGGTGGTGGCATCCGGGGCTCAACTCGCCCTCGTTATTGGAG
GCGGGAATATTTTCCGCGGTCTGGCAGCTTCCTCCAAGGGGATGGACCGTGCCAGCGCCGACTACATGGGGATGCTGGCC
ACCATGATCAATTCACTGGCCATGCAGGACGCACTTGAGAAGATAGGTGTCGATACCAGGGTACAGTCGGCCATTGCCAT
GCAGGAGGTCGCAGAGCCGTACATCAGGCGACGTGCCATGCGGCACCTGGAGAAGGGGCGGGTCGTCATATTCGGCGCCG
GTACCGGTAACCCGTATTTCACCACCGATACAGCGGCAAGCCTACGAGCCATGGAAATCGGAGCAGATGTGATTCTCAAG
GGAACCAAGGTGGATGGCGTCTACTCGGCCGACCCAAAGAAAGATCCCACCGCCCAGAAATACCCCCGGCTCACGTATCT
GGAGGTCCTCAAAAAAGGGCTTCAGGTAATGGATGCAACTGCTACCTCGCTCTGTATGGACAACAATCTCCCCATTATCG
TTTTTGACATCACCACATATGGCAACATAAAAAAGGTGGTGTGCGGTGAAGAGATCGGCACCGTTGTGAAAGGAGAATAG

Upstream 100 bases:

>100_bases
TGTAAGAAGGTGGACGGGCCGGCCATGCTCCATGGCCGGCCTTTTTTACGTCCACAGCAGAATATGAGTTCCATTTACCA
GGCGTGAGGGCCGACACACC

Downstream 100 bases:

>100_bases
CATGACGAAAGAAGTCATTGCCGACATGAAGGCGCACATGGAAAAGTCGGTTGACGCACTTCGCCGCGAATACCAGAAGG
TGCGCACCGGCAGGGCCACC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MGTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRGLAASSKGMDRASADYMGMLA
TMINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILK
GTKVDGVYSADPKKDPTAQKYPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE

Sequences:

>Translated_239_residues
MGTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRGLAASSKGMDRASADYMGMLA
TMINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILK
GTKVDGVYSADPKKDPTAQKYPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE
>Mature_238_residues
GTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRGLAASSKGMDRASADYMGMLAT
MINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKG
TKVDGVYSADPKKDPTAQKYPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=54.5064377682403, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_GEOMG (Q39W86)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384213.1
- HSSP:   P65938
- ProteinModelPortal:   Q39W86
- SMR:   Q39W86
- STRING:   Q39W86
- GeneID:   3738795
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1252
- NMPDR:   fig|269799.3.peg.1930
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q39W86
- ProtClustDB:   PRK00358
- BioCyc:   GMET269799:GMET_1252-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25533; Mature: 25402

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 162-162 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRG
CCCHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSKGMDRASADYMGMLATMINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAM
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKGTKVDGVYSADPKKDPTAQK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHHEECCEEEEECCCCCCEECCCCCCCCCHHH
YPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECHHHCCEECCC
>Mature Secondary Structure 
GTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRG
CCHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHH
LAASSKGMDRASADYMGMLATMINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAM
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKGTKVDGVYSADPKKDPTAQK
HHHHCCCEEEEECCCCCCEEECCHHHHHHHHEECCEEEEECCCCCCEECCCCCCCCCHHH
YPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCEEEEEECHHHCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA