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The map label for this gene is appC [H]

Identifier: 78222450

GI number: 78222450

Start: 1394788

End: 1395642

Strand: Direct

Name: appC [H]

Synonym: Gmet_1236

Alternate gene names: 78222450

Gene position: 1394788-1395642 (Clockwise)

Preceding gene: 78222449

Following gene: 78222451

Centisome position: 34.89

GC content: 63.39

Gene sequence:

>855_bases
ATGGCCTTTCGGGAAAGCTGGTTCCATACGGTTTTCTGGAAGCGGTTCCGGCACAACCGGTTTGCCATGGCCGGCGGGTG
TGTCGTGCTCCTTCTCTTTGTGGTGTCGCTGCTGGCTCCGTATATCACCCCCTGGGACCCCCACGCCATCGACGCCTATC
ATGTGCTCCTTCCCCCTTCGGCGAACCACTGGTTCGGCACCGACGAGCTGGGGCGCGACGTCTTTACCCGGGTGGTCTAC
GGGGCGCGGATTTCCCTCAAGGTGGGGTTCGTCTCGGTGGGGATCGCCGTGGCCATCGGGGTGGTGCTGGGGCTTGTTTC
CGGCTTCTACGGCGGCATCATCGATACCGTCATCATGCGGTTTGTGGATATCATGCTCTGTTTCCCCACCTTTTTCCTGA
TCCTGGCGGTGATCGCTTTTCTGGAACCGTCCATCTGGTATATCATGGCGATTATCGGCCTCACGGGGTGGATGGGGGTG
GCGCGGCTCGTGCGGGCCGAGGTGCTGTCGCTGCGGGAGCGGGACTTCATTCTGGCGGCCCGGGCGCTGGGGGCGTCCGA
TGCGCGGATCATCTTCCGTCACATCCTTCCCAACGCCCTGTCACCGGTGCTCGTCTCTGCTACCCTTGGCGTGGCAGGGG
CCATCCTCACGGAGTCGGCCCTGTCGTTTCTCGGCATCGGCGTGCAACCCCCCACGCCCAGTTGGGGGAACATCCTCACG
TCGGGCAAGGATTACATCGAGTTCGGTTGGTGGCTCTCCCTGTTCCCCGGCCTGGCCATTCTGGTGACGGTCCTTGCCTA
CAACCTCCTGGGGGAGGGGATTCGCGACGCCCTCGACCCCCGGCTGAATCGCTGA

Upstream 100 bases:

>100_bases
TCTGGTGATTGGCGCGTTCCTTACCCTTGTCGGCAATCTCCTGGCCGATCTCTGCTATGCCATGGCCGATCCGCGTATCA
GGCACGGGAGGGGGTAGGAA

Downstream 100 bases:

>100_bases
AATTTTTGATAAATCCGAGGAGTACCATGTCAGACAACAACCAGTCCACGCGGCAGCAGATGACAGAGCCCGCCGTCAAC
AAGGACAAGTTCGCAATTGT

Product: binding-protein dependent transport system inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPSANHWFGTDELGRDVFTRVVY
GARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMRFVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGV
ARLVRAEVLSLRERDFILAARALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILT
SGKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR

Sequences:

>Translated_284_residues
MAFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPSANHWFGTDELGRDVFTRVVY
GARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMRFVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGV
ARLVRAEVLSLRERDFILAARALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILT
SGKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR
>Mature_283_residues
AFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPSANHWFGTDELGRDVFTRVVYG
ARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMRFVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGVA
RLVRAEVLSLRERDFILAARALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILTS
GKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=281, Percent_Identity=43.4163701067616, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787760, Length=266, Percent_Identity=41.3533834586466, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1789964, Length=279, Percent_Identity=43.3691756272401, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1787498, Length=270, Percent_Identity=41.4814814814815, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1789889, Length=239, Percent_Identity=38.4937238493724, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788505, Length=225, Percent_Identity=40, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1787549, Length=277, Percent_Identity=32.8519855595668, Blast_Score=133, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31248; Mature: 31117

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPS
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
ANHWFGTDELGRDVFTRVVYGARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMR
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGVARLVRAEVLSLRERDFILAA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHC
SGKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPS
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
ANHWFGTDELGRDVFTRVVYGARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMR
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGVARLVRAEVLSLRERDFILAA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHC
SGKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]