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The map label for this gene is 78222447

Identifier: 78222447

GI number: 78222447

Start: 1390389

End: 1392110

Strand: Direct

Name: 78222447

Synonym: Gmet_1233

Alternate gene names: NA

Gene position: 1390389-1392110 (Clockwise)

Preceding gene: 78222442

Following gene: 78222448

Centisome position: 34.78

GC content: 55.23

Gene sequence:

>1722_bases
ATGAAAAAACGTATTGTCGTGGCATTATTCCTGGCTCTTTCCTTTCTTCCGGGATGCGCCACAAACGGCGCGGGAAAGCC
TCTTCCTGCCAACGAGCATTCATTTCAGCCGACCGTCAATATTGCCGGATCCAGGGCTCTCTACATTTATTCATTGTCGC
GTCTCCGCGAGCTGGACGGGGATTTCGAGGGTGCGCTCACGCTCCTGAATGGTGCCATTGAGGCTGACCCCAACTCCGCG
TTTCTTCATACGGCAGCCGCCGAGATCTATCTGAAATCGGGCAAACTCGACGATGCGCTCCGTGCATGTGAAAACGCCAT
CCGCGTCGATCCCGGGTTCCGTCCGGCACGGATCATTGCCGGGACCATCCTGGCAAACCTCAAGCGGGACAAGGAAGCTA
TTGTCCATCTCAGCAAGGCCATTGAGCTTGATCCGACCAAGGAGGATGCCTATCTCCACCTGGCCATCTCCTATGTCCGA
ACCTTCGATTACGAGCAGGCGGTTAACACCCTCAAGTCCCTGATCAAGATCAACCCCGAGTCATCGCTGGGCTACTATTA
CCTGGGCAAGACCTACGACCAGATGAAGCTCCAGAAGGAGGCTGCCAACTATTACAAGAAGGCCATCGAGATCAAGCCCG
ATTTCGAGCAGGCCATAATCGACCTGGGGATTTCCCAGGAGGGGCTCGGCCTCTATGATGATGCCATCGCCACCTACAAG
CGGCTGCTTGAGACAAATCCGTTCAACATGAACGTGCTGCAGCACCTGGTGCAGCTTTACCTCCAGCAGCAGCGGCTGGA
GGACGCGCTCCCACTGCTCATCGTGATGAAGGATCGGGGTGTCGGCGGCCTGGAAACCCAGCGCAAGATCGGCCTCATCT
ATATGGAACTGGAGCGCTATGACGAGGCAATCGCCGAATTCGAGCAGATCCTTGCCCGGGAACCCAAGGCCCACCAGATT
CGCTTCTACATTGCGAGCGCTTACGAGGAGAAAGAGGAGTTCGACAAGGCCATAGAGGAATTCAGTAAGATTCCTCCGGG
AACCGCCAATTACGTTGAGGCCTTGGGGCACATCGCTTTCATGTACCGGGATCAGGAAAAACCTGAGAAGGGAATCCAGA
TCCTGACGGATGCCATTACTGCCAATCCCGATAAATTGGACCTCTATCTCTATCTGGCCGGTCTGTACGAATCAATGGAT
AAGTTCTCAGAAGGACTTGCCGTTCTCAAGGGGGTTGAAGGGAAATTTGCCGAGGACCCGAGGCTCCACTTCCGGATGGG
AACCATCCTCGACAAAATGGGGAACAAGGAGGAGTCCATCGCCCGGATGAAGCGGGTTATCGCCATTACGCCCGACGATG
CCCAGGCCCTCAACTATCTGGGCTATACCTACGCCGAGATGGGCATCAAGCTGGATGAAGCCCTCCAGTACCTCAAGAAG
GCCGTGGCGCTTCGTCCCAACGACGGTTTTATTCTCGACAGTCTCGGCTGGGTCTACTTCAAGATGAAGCGTTATGACGA
GGCCGTGCCGCTCCTGGAGCGGTCGCTCAAGGTCGTGGAGGACGATCTGACGGTCATGGAGCACCTGGCCGACGCCTATG
CAGCCAACCATGAATACCGCAATGCCTTGAAACTTTACAAAAAGATCCTCGACGCCGACCCGGGTCGCAAGGATATCGCC
GAAAAGAAGAAAAAGGTCAGGGCGGAAAGTCTGGAAAAATGA

Upstream 100 bases:

>100_bases
TGAACACTTATTTCACTTTACCATATTCGGAACAACGGAGTAGATGCGGGGCTTTCGGGCGTCTTTCCCGCTTCAGGCAG
ACGTAGGCACGGGTAACTGC

Downstream 100 bases:

>100_bases
CGGCACGGCTGTTCTGCTGTCTTGCGGCACTGGTTACCCTTGTTTCGTGCAGCGGCGGTACGCCTCCTGCGGAACTGCCG
CGGCGTGGAGCAGGGGCCCC

Product: intermediate filament protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MKKRIVVALFLALSFLPGCATNGAGKPLPANEHSFQPTVNIAGSRALYIYSLSRLRELDGDFEGALTLLNGAIEADPNSA
FLHTAAAEIYLKSGKLDDALRACENAIRVDPGFRPARIIAGTILANLKRDKEAIVHLSKAIELDPTKEDAYLHLAISYVR
TFDYEQAVNTLKSLIKINPESSLGYYYLGKTYDQMKLQKEAANYYKKAIEIKPDFEQAIIDLGISQEGLGLYDDAIATYK
RLLETNPFNMNVLQHLVQLYLQQQRLEDALPLLIVMKDRGVGGLETQRKIGLIYMELERYDEAIAEFEQILAREPKAHQI
RFYIASAYEEKEEFDKAIEEFSKIPPGTANYVEALGHIAFMYRDQEKPEKGIQILTDAITANPDKLDLYLYLAGLYESMD
KFSEGLAVLKGVEGKFAEDPRLHFRMGTILDKMGNKEESIARMKRVIAITPDDAQALNYLGYTYAEMGIKLDEALQYLKK
AVALRPNDGFILDSLGWVYFKMKRYDEAVPLLERSLKVVEDDLTVMEHLADAYAANHEYRNALKLYKKILDADPGRKDIA
EKKKKVRAESLEK

Sequences:

>Translated_573_residues
MKKRIVVALFLALSFLPGCATNGAGKPLPANEHSFQPTVNIAGSRALYIYSLSRLRELDGDFEGALTLLNGAIEADPNSA
FLHTAAAEIYLKSGKLDDALRACENAIRVDPGFRPARIIAGTILANLKRDKEAIVHLSKAIELDPTKEDAYLHLAISYVR
TFDYEQAVNTLKSLIKINPESSLGYYYLGKTYDQMKLQKEAANYYKKAIEIKPDFEQAIIDLGISQEGLGLYDDAIATYK
RLLETNPFNMNVLQHLVQLYLQQQRLEDALPLLIVMKDRGVGGLETQRKIGLIYMELERYDEAIAEFEQILAREPKAHQI
RFYIASAYEEKEEFDKAIEEFSKIPPGTANYVEALGHIAFMYRDQEKPEKGIQILTDAITANPDKLDLYLYLAGLYESMD
KFSEGLAVLKGVEGKFAEDPRLHFRMGTILDKMGNKEESIARMKRVIAITPDDAQALNYLGYTYAEMGIKLDEALQYLKK
AVALRPNDGFILDSLGWVYFKMKRYDEAVPLLERSLKVVEDDLTVMEHLADAYAANHEYRNALKLYKKILDADPGRKDIA
EKKKKVRAESLEK
>Mature_573_residues
MKKRIVVALFLALSFLPGCATNGAGKPLPANEHSFQPTVNIAGSRALYIYSLSRLRELDGDFEGALTLLNGAIEADPNSA
FLHTAAAEIYLKSGKLDDALRACENAIRVDPGFRPARIIAGTILANLKRDKEAIVHLSKAIELDPTKEDAYLHLAISYVR
TFDYEQAVNTLKSLIKINPESSLGYYYLGKTYDQMKLQKEAANYYKKAIEIKPDFEQAIIDLGISQEGLGLYDDAIATYK
RLLETNPFNMNVLQHLVQLYLQQQRLEDALPLLIVMKDRGVGGLETQRKIGLIYMELERYDEAIAEFEQILAREPKAHQI
RFYIASAYEEKEEFDKAIEEFSKIPPGTANYVEALGHIAFMYRDQEKPEKGIQILTDAITANPDKLDLYLYLAGLYESMD
KFSEGLAVLKGVEGKFAEDPRLHFRMGTILDKMGNKEESIARMKRVIAITPDDAQALNYLGYTYAEMGIKLDEALQYLKK
AVALRPNDGFILDSLGWVYFKMKRYDEAVPLLERSLKVVEDDLTVMEHLADAYAANHEYRNALKLYKKILDADPGRKDIA
EKKKKVRAESLEK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI32307148, Length=503, Percent_Identity=23.2604373757455, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI32307150, Length=496, Percent_Identity=22.1774193548387, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI83415184, Length=533, Percent_Identity=20.0750469043152, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI301336134, Length=406, Percent_Identity=20.4433497536946, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532690, Length=526, Percent_Identity=23.0038022813688, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115532692, Length=425, Percent_Identity=23.5294117647059, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25147174, Length=258, Percent_Identity=22.8682170542636, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17647755, Length=404, Percent_Identity=22.029702970297, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585827, Length=404, Percent_Identity=22.029702970297, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585829, Length=404, Percent_Identity=22.029702970297, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011717
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07719 TPR_2; PF07721 TPR_4 [H]

EC number: NA

Molecular weight: Translated: 64769; Mature: 64769

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50005 TPR L=RR ; PS50293 TPR_REGION ; PS00226 IF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRIVVALFLALSFLPGCATNGAGKPLPANEHSFQPTVNIAGSRALYIYSLSRLRELDG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHCC
DFEGALTLLNGAIEADPNSAFLHTAAAEIYLKSGKLDDALRACENAIRVDPGFRPARIIA
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHEECCCCCCHHHHHH
GTILANLKRDKEAIVHLSKAIELDPTKEDAYLHLAISYVRTFDYEQAVNTLKSLIKINPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHCCCCC
SSLGYYYLGKTYDQMKLQKEAANYYKKAIEIKPDFEQAIIDLGISQEGLGLYDDAIATYK
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
RLLETNPFNMNVLQHLVQLYLQQQRLEDALPLLIVMKDRGVGGLETQRKIGLIYMELERY
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCEEEEHHHHH
DEAIAEFEQILAREPKAHQIRFYIASAYEEKEEFDKAIEEFSKIPPGTANYVEALGHIAF
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MYRDQEKPEKGIQILTDAITANPDKLDLYLYLAGLYESMDKFSEGLAVLKGVEGKFAEDP
HHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RLHFRMGTILDKMGNKEESIARMKRVIAITPDDAQALNYLGYTYAEMGIKLDEALQYLKK
CHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVALRPNDGFILDSLGWVYFKMKRYDEAVPLLERSLKVVEDDLTVMEHLADAYAANHEYR
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
NALKLYKKILDADPGRKDIAEKKKKVRAESLEK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKRIVVALFLALSFLPGCATNGAGKPLPANEHSFQPTVNIAGSRALYIYSLSRLRELDG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHCC
DFEGALTLLNGAIEADPNSAFLHTAAAEIYLKSGKLDDALRACENAIRVDPGFRPARIIA
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHEECCCCCCHHHHHH
GTILANLKRDKEAIVHLSKAIELDPTKEDAYLHLAISYVRTFDYEQAVNTLKSLIKINPE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHCCCCC
SSLGYYYLGKTYDQMKLQKEAANYYKKAIEIKPDFEQAIIDLGISQEGLGLYDDAIATYK
CCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHH
RLLETNPFNMNVLQHLVQLYLQQQRLEDALPLLIVMKDRGVGGLETQRKIGLIYMELERY
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCEEEEHHHHH
DEAIAEFEQILAREPKAHQIRFYIASAYEEKEEFDKAIEEFSKIPPGTANYVEALGHIAF
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MYRDQEKPEKGIQILTDAITANPDKLDLYLYLAGLYESMDKFSEGLAVLKGVEGKFAEDP
HHCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RLHFRMGTILDKMGNKEESIARMKRVIAITPDDAQALNYLGYTYAEMGIKLDEALQYLKK
CHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVALRPNDGFILDSLGWVYFKMKRYDEAVPLLERSLKVVEDDLTVMEHLADAYAANHEYR
HHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
NALKLYKKILDADPGRKDIAEKKKKVRAESLEK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883699; 10984043 [H]