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The map label for this gene is pgcA [H]

Identifier: 78188452

GI number: 78188452

Start: 554056

End: 555438

Strand: Reverse

Name: pgcA [H]

Synonym: Cag_0474

Alternate gene names: 78188452

Gene position: 555438-554056 (Counterclockwise)

Preceding gene: 78188455

Following gene: 78188451

Centisome position: 21.59

GC content: 43.31

Gene sequence:

>1383_bases
ATGCAAATTAAATTTGGTACCGACGGATGGCGTGCAATTATTGCTAAAGAGTACACCTTCGATAACTTAAAAATTGTAGC
ACTTGCCGCATCTCGCTACTTCCTAAGCCATCCAAACCGAGCAAAAGGCGTTTGCATTGGCTACGATACCCGCTTTATGT
CGAAGGAATTTGCCGAGTACACCGCTCAAATTTTTTCATCACAAGGGCTGCGCGTTTTTCTTTCCGATAGCTTTGTTTCT
ACGCCAGCCGTCTCGCTTTACACGCGCGATAAAGAGCTTGCTGGTGGCGTTGTTATTACCGCTTCGCACAATCCTGCGCT
TTATAACGGTTTTAAAATTAAAGCGCATTATGGTGGACCTGCCCACCCCGAAGTTATCACGGAAATTGAGGACTATATTG
CTCAAGTGAACCCTGCTACAGAAATTGTGACCGAGCCAAAGCTTATTGAAATGGTTGATATGAAAGGCTTTTACATCAGC
CATCTTAAAGCCTCAATTGACTTACAACTCATTCGTGATTCTCGCATTAAAATTGCCCACAACGCCATGTTTGGGGCAGG
GCAGGATATTTTATCGCGCCTTTTTGATGAGTCTATGCTTAGTTGTTACCACTGTTCGGTGAACCCATCGTTTGGTGGCA
TTAATCCTGAGCCAATTCCTCAATACACCACTGATTTTGTTGATTTCTTTAAAGAAATTGAGTGCGACGTTGCCATTATG
AACGATGGCGATGCTGACCGTATAGGAATGCTTGATGAGCAAGGCAATTTTGTGGATTCGCACAAGCTCTTTGCTATTAT
TTTAAAATATTTAATTGAAGAGCGCCACTTACCGGGCGAAGTTGCTAAAACCTTTGCACTCACCGACCTTATTGATAAAA
TTTGCCAAAAGCATAATGTTGTGATGCACGAAATTCCCATTGGCTTTAAGCACGTAAGCAAACTTATGACAACCAATACC
ATTTTAATTGGTGGCGAAGAGTCGGGCGGCATTGGCATTCCTTCATTCCTACCCGAACGCGATGGCATTTACATTGGTTT
GCTCATTTTGGAAATGATGACGAACAAAGAAAAAAGCCTTTCACAGTTAGTGCAAGAATTGTACGATGAGTATGGCTTTT
TTAGCTACAACCGCCTCGATATGCGGGTAAGCGAAGAAAAAAAGCAAGCCATTATGGCTCGTGCCGCACAAGGCGATTTA
ACCTCCATTGCAGGCTATAACGTCTTGAAATTTGGCGATCTTGATGGGTACAAGTACCACTTTGAAGGCGGTTGGCTGCT
TATTCGTGCTTCAGGTACTGAGCCAATTTTGCGCATTTACTGTGAAGCTGATTCGGCGGAAAAGGTTGAAAAGGTGTTAG
CCTTTGCCTCAAAACTTGCATAG

Upstream 100 bases:

>100_bases
GCCGAATTTTTTTAAGCATCTTACGGCTCGTATAATAAGCGTTTATAACGCCAATGCAGAAGTAAAAGATGCTTTTTAAT
TATATCAACATCGTTTTACA

Downstream 100 bases:

>100_bases
CGTCTTATCGAAAAAGGGTGAGCCGTGCAGTCTAAAAAAACCTGCACGGCTTTTCTTCACAAAAAAAATTTGGATCGCGC
TGGTTTTTCGGCTTCCCCAT

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MQIKFGTDGWRAIIAKEYTFDNLKIVALAASRYFLSHPNRAKGVCIGYDTRFMSKEFAEYTAQIFSSQGLRVFLSDSFVS
TPAVSLYTRDKELAGGVVITASHNPALYNGFKIKAHYGGPAHPEVITEIEDYIAQVNPATEIVTEPKLIEMVDMKGFYIS
HLKASIDLQLIRDSRIKIAHNAMFGAGQDILSRLFDESMLSCYHCSVNPSFGGINPEPIPQYTTDFVDFFKEIECDVAIM
NDGDADRIGMLDEQGNFVDSHKLFAIILKYLIEERHLPGEVAKTFALTDLIDKICQKHNVVMHEIPIGFKHVSKLMTTNT
ILIGGEESGGIGIPSFLPERDGIYIGLLILEMMTNKEKSLSQLVQELYDEYGFFSYNRLDMRVSEEKKQAIMARAAQGDL
TSIAGYNVLKFGDLDGYKYHFEGGWLLIRASGTEPILRIYCEADSAEKVEKVLAFASKLA

Sequences:

>Translated_460_residues
MQIKFGTDGWRAIIAKEYTFDNLKIVALAASRYFLSHPNRAKGVCIGYDTRFMSKEFAEYTAQIFSSQGLRVFLSDSFVS
TPAVSLYTRDKELAGGVVITASHNPALYNGFKIKAHYGGPAHPEVITEIEDYIAQVNPATEIVTEPKLIEMVDMKGFYIS
HLKASIDLQLIRDSRIKIAHNAMFGAGQDILSRLFDESMLSCYHCSVNPSFGGINPEPIPQYTTDFVDFFKEIECDVAIM
NDGDADRIGMLDEQGNFVDSHKLFAIILKYLIEERHLPGEVAKTFALTDLIDKICQKHNVVMHEIPIGFKHVSKLMTTNT
ILIGGEESGGIGIPSFLPERDGIYIGLLILEMMTNKEKSLSQLVQELYDEYGFFSYNRLDMRVSEEKKQAIMARAAQGDL
TSIAGYNVLKFGDLDGYKYHFEGGWLLIRASGTEPILRIYCEADSAEKVEKVLAFASKLA
>Mature_460_residues
MQIKFGTDGWRAIIAKEYTFDNLKIVALAASRYFLSHPNRAKGVCIGYDTRFMSKEFAEYTAQIFSSQGLRVFLSDSFVS
TPAVSLYTRDKELAGGVVITASHNPALYNGFKIKAHYGGPAHPEVITEIEDYIAQVNPATEIVTEPKLIEMVDMKGFYIS
HLKASIDLQLIRDSRIKIAHNAMFGAGQDILSRLFDESMLSCYHCSVNPSFGGINPEPIPQYTTDFVDFFKEIECDVAIM
NDGDADRIGMLDEQGNFVDSHKLFAIILKYLIEERHLPGEVAKTFALTDLIDKICQKHNVVMHEIPIGFKHVSKLMTTNT
ILIGGEESGGIGIPSFLPERDGIYIGLLILEMMTNKEKSLSQLVQELYDEYGFFSYNRLDMRVSEEKKQAIMARAAQGDL
TSIAGYNVLKFGDLDGYKYHFEGGWLLIRASGTEPILRIYCEADSAEKVEKVLAFASKLA

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI21361621, Length=375, Percent_Identity=27.2, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI290463102, Length=379, Percent_Identity=26.3852242744063, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI133922562, Length=376, Percent_Identity=27.1276595744681, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI290463104, Length=215, Percent_Identity=26.046511627907, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI63055049, Length=421, Percent_Identity=23.9904988123515, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI31377548, Length=436, Percent_Identity=22.0183486238532, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786904, Length=490, Percent_Identity=26.734693877551, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789566, Length=464, Percent_Identity=25.4310344827586, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788361, Length=416, Percent_Identity=21.6346153846154, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535441, Length=425, Percent_Identity=24.4705882352941, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71993870, Length=515, Percent_Identity=25.0485436893204, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71993878, Length=275, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323752, Length=407, Percent_Identity=26.2899262899263, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322722, Length=410, Percent_Identity=26.5853658536585, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323934, Length=406, Percent_Identity=24.6305418719212, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17864244, Length=376, Percent_Identity=27.1276595744681, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24653722, Length=424, Percent_Identity=23.3490566037736, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24651977, Length=426, Percent_Identity=23.0046948356808, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129809, Length=430, Percent_Identity=22.5581395348837, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 51468; Mature: 51468

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKFGTDGWRAIIAKEYTFDNLKIVALAASRYFLSHPNRAKGVCIGYDTRFMSKEFAEY
CEEEECCCCCEEEEEEEEECCCEEEEEEEEHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
TAQIFSSQGLRVFLSDSFVSTPAVSLYTRDKELAGGVVITASHNPALYNGFKIKAHYGGP
HHHHHCCCCCEEEEECCCCCCCEEEEEECCHHHCCCEEEEECCCCCEECCEEEEEECCCC
AHPEVITEIEDYIAQVNPATEIVTEPKLIEMVDMKGFYISHLKASIDLQLIRDSRIKIAH
CCHHHHHHHHHHHHHCCCHHHHHCCCHHEEEECCCCCEEEHHHHEEEEEEECCCCEEEEE
NAMFGAGQDILSRLFDESMLSCYHCSVNPSFGGINPEPIPQYTTDFVDFFKEIECDVAIM
HHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
NDGDADRIGMLDEQGNFVDSHKLFAIILKYLIEERHLPGEVAKTFALTDLIDKICQKHNV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCE
VMHEIPIGFKHVSKLMTTNTILIGGEESGGIGIPSFLPERDGIYIGLLILEMMTNKEKSL
EEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCHHHH
SQLVQELYDEYGFFSYNRLDMRVSEEKKQAIMARAAQGDLTSIAGYNVLKFGDLDGYKYH
HHHHHHHHHHHCCEEEEEEEEEECHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCCEEEE
FEGGWLLIRASGTEPILRIYCEADSAEKVEKVLAFASKLA
EECCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIKFGTDGWRAIIAKEYTFDNLKIVALAASRYFLSHPNRAKGVCIGYDTRFMSKEFAEY
CEEEECCCCCEEEEEEEEECCCEEEEEEEEHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
TAQIFSSQGLRVFLSDSFVSTPAVSLYTRDKELAGGVVITASHNPALYNGFKIKAHYGGP
HHHHHCCCCCEEEEECCCCCCCEEEEEECCHHHCCCEEEEECCCCCEECCEEEEEECCCC
AHPEVITEIEDYIAQVNPATEIVTEPKLIEMVDMKGFYISHLKASIDLQLIRDSRIKIAH
CCHHHHHHHHHHHHHCCCHHHHHCCCHHEEEECCCCCEEEHHHHEEEEEEECCCCEEEEE
NAMFGAGQDILSRLFDESMLSCYHCSVNPSFGGINPEPIPQYTTDFVDFFKEIECDVAIM
HHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
NDGDADRIGMLDEQGNFVDSHKLFAIILKYLIEERHLPGEVAKTFALTDLIDKICQKHNV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCE
VMHEIPIGFKHVSKLMTTNTILIGGEESGGIGIPSFLPERDGIYIGLLILEMMTNKEKSL
EEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCHHHH
SQLVQELYDEYGFFSYNRLDMRVSEEKKQAIMARAAQGDLTSIAGYNVLKFGDLDGYKYH
HHHHHHHHHHHCCEEEEEEEEEECHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCCEEEE
FEGGWLLIRASGTEPILRIYCEADSAEKVEKVLAFASKLA
EECCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA