Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 78188401

GI number: 78188401

Start: 497006

End: 498565

Strand: Reverse

Name: ppx [H]

Synonym: Cag_0423

Alternate gene names: 78188401

Gene position: 498565-497006 (Counterclockwise)

Preceding gene: 78188402

Following gene: 78188400

Centisome position: 19.38

GC content: 46.99

Gene sequence:

>1560_bases
ATGAATAAAGAAGCATTGCGCGTAGCGGCTATTGATCTTGGTACCAACTCTTTCCACATGATTATTGTGGAGGGAAGTCG
CGATAAAGGTATTGTTGAAATTGACCGCGTGAAGGATATGATTGGCATTGGGCATGGCAGTATTGCCACTAAAATGCTGA
CGGAGGAGGCAATGCAAGCGGGCATAGCAACGCTAAAGAAGTTTTTAGTGTTAGCTGCCCAGCATGGCGTGCAATTTGAG
CATATTCTTGCTTTTGCTACCAGCGCCATTCGCGAAGCAAAAAATCGTCTTGATTTTATTAATCGTGTTCGGGCTGAAAC
GGGCTTAAAAGTCAAGATTATTTCGGGTAAAGAGGAGGCGGAGTTTATTTACTACGGCGTGCGCAATGCGGTAAGTGTTG
GCAAAACGGCGGATTTGATTTTTGATATTGGTGGCGGTTCGGTGGAGTTTGTGTTAGTGAATCACAAAGGGGTGCAACTG
CTTGAAAGCCGTAAAATTGGTGTGGCGCGTATGCACGAGCGCTTTGTTTCAAGCGATCCCATAGCAGCAAACGATGTTAA
AATGCTTGAACAATTTTTTGCGGCTGAAATGGTTTCGGCGGTGGATAAAGCTACGACAATGAAAGTGCGTCGTGCGGTTG
CGTCATCAGGCACAGCCGAGACCATTGCCCGCATGATTCACGCCATGCAAGGGCGCGATAGCGATGGCGCGTTAAACAAT
AGTTGCTTTACGCGCAGTGAGTTTCAGCAACTCTACCACACCGTGTTGCTCATGAATTCAGCAGAGCGCAAAAAAATGAG
CGGCTTGGATGAAAAGCGGGTTGATTTAATTGTGCCAGGGCTCATTTTAGTGGATATGATTTTTAAGCTCTTTCGGCTTG
AAGAAATTGTTATTGCCGATTCGGCTTTGCGTGAAGGCATGGTGCTGCACTACTTGCAGCAGCAAGGTTCGGTGCTTAAA
AAACGAGGTCATCAAGAATCGCTTGATATTCGGCGCGAAAGCGTTAATGAGCTGGGATTCCGTTGCCATTGGGATCGTGG
GCATTCGGAATACATTGCTCGCCTCTGCCTTCAGCTTTTCGATAAACTTGCTCCCCTCCATCAGCTTGAAGAAAATTATC
GTGAATTGCTGGAATATTCTGCTCTTCTGCACAACATTGGAGCCTTTATTTCAATCTCCTCCCATCATAAGCATAGCCAA
TACATTGTCATGAATGGCGAGTTGCGCGGCTTTTCTCCCTCCGAAATTGCCATTCTTGGGCATGTAGTGCGCTACCATCG
TAAGTCGCCCCCTTCCGAAAAACATACGCCCTATAATGCCTTAAAGCTGCCGCACAAACGGGCGGTTGATGTGCTTTCGG
GCATTTTGCGCATTGCCAACGGCTTGGAACGTGGACATCGCCAAAACGTGCAAAATGTTGATGTGCAAGTAAAAGGCAAA
AGCATTACCATGGCGCTAACCTGCTGCTTTGAACCCGATATTGAAATATGGGCAGCCGATCAACTCAAGGCGTGGCTTGA
AACGGTGCTACAAAAAACCATCCATTTTCAACGCGCGTAA

Upstream 100 bases:

>100_bases
GCTCATAACAATTTTTAGTGATGTCCTTAAACGTATTTAGTTTACGGATGATATTCGGTGCTTTTTCTTGCGCCGTTTTT
AATACTTCCATTATAAAAAA

Downstream 100 bases:

>100_bases
CAATGGGCAAGCAACCAGCTCCCCCTCCTTTCCACCATCCCGCGTTGCCGCTTCAGCAACATGGAACGCTTTGGTTGGAA
TCATCATTTTGCGACAATGG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNKEALRVAAIDLGTNSFHMIIVEGSRDKGIVEIDRVKDMIGIGHGSIATKMLTEEAMQAGIATLKKFLVLAAQHGVQFE
HILAFATSAIREAKNRLDFINRVRAETGLKVKIISGKEEAEFIYYGVRNAVSVGKTADLIFDIGGGSVEFVLVNHKGVQL
LESRKIGVARMHERFVSSDPIAANDVKMLEQFFAAEMVSAVDKATTMKVRRAVASSGTAETIARMIHAMQGRDSDGALNN
SCFTRSEFQQLYHTVLLMNSAERKKMSGLDEKRVDLIVPGLILVDMIFKLFRLEEIVIADSALREGMVLHYLQQQGSVLK
KRGHQESLDIRRESVNELGFRCHWDRGHSEYIARLCLQLFDKLAPLHQLEENYRELLEYSALLHNIGAFISISSHHKHSQ
YIVMNGELRGFSPSEIAILGHVVRYHRKSPPSEKHTPYNALKLPHKRAVDVLSGILRIANGLERGHRQNVQNVDVQVKGK
SITMALTCCFEPDIEIWAADQLKAWLETVLQKTIHFQRA

Sequences:

>Translated_519_residues
MNKEALRVAAIDLGTNSFHMIIVEGSRDKGIVEIDRVKDMIGIGHGSIATKMLTEEAMQAGIATLKKFLVLAAQHGVQFE
HILAFATSAIREAKNRLDFINRVRAETGLKVKIISGKEEAEFIYYGVRNAVSVGKTADLIFDIGGGSVEFVLVNHKGVQL
LESRKIGVARMHERFVSSDPIAANDVKMLEQFFAAEMVSAVDKATTMKVRRAVASSGTAETIARMIHAMQGRDSDGALNN
SCFTRSEFQQLYHTVLLMNSAERKKMSGLDEKRVDLIVPGLILVDMIFKLFRLEEIVIADSALREGMVLHYLQQQGSVLK
KRGHQESLDIRRESVNELGFRCHWDRGHSEYIARLCLQLFDKLAPLHQLEENYRELLEYSALLHNIGAFISISSHHKHSQ
YIVMNGELRGFSPSEIAILGHVVRYHRKSPPSEKHTPYNALKLPHKRAVDVLSGILRIANGLERGHRQNVQNVDVQVKGK
SITMALTCCFEPDIEIWAADQLKAWLETVLQKTIHFQRA
>Mature_519_residues
MNKEALRVAAIDLGTNSFHMIIVEGSRDKGIVEIDRVKDMIGIGHGSIATKMLTEEAMQAGIATLKKFLVLAAQHGVQFE
HILAFATSAIREAKNRLDFINRVRAETGLKVKIISGKEEAEFIYYGVRNAVSVGKTADLIFDIGGGSVEFVLVNHKGVQL
LESRKIGVARMHERFVSSDPIAANDVKMLEQFFAAEMVSAVDKATTMKVRRAVASSGTAETIARMIHAMQGRDSDGALNN
SCFTRSEFQQLYHTVLLMNSAERKKMSGLDEKRVDLIVPGLILVDMIFKLFRLEEIVIADSALREGMVLHYLQQQGSVLK
KRGHQESLDIRRESVNELGFRCHWDRGHSEYIARLCLQLFDKLAPLHQLEENYRELLEYSALLHNIGAFISISSHHKHSQ
YIVMNGELRGFSPSEIAILGHVVRYHRKSPPSEKHTPYNALKLPHKRAVDVLSGILRIANGLERGHRQNVQNVDVQVKGK
SITMALTCCFEPDIEIWAADQLKAWLETVLQKTIHFQRA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=435, Percent_Identity=30.3448275862069, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI48994966, Length=457, Percent_Identity=27.3522975929978, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 58250; Mature: 58250

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEALRVAAIDLGTNSFHMIIVEGSRDKGIVEIDRVKDMIGIGHGSIATKMLTEEAMQA
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHH
GIATLKKFLVLAAQHGVQFEHILAFATSAIREAKNRLDFINRVRAETGLKVKIISGKEEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
EFIYYGVRNAVSVGKTADLIFDIGGGSVEFVLVNHKGVQLLESRKIGVARMHERFVSSDP
CEEEEEHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCC
IAANDVKMLEQFFAAEMVSAVDKATTMKVRRAVASSGTAETIARMIHAMQGRDSDGALNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
SCFTRSEFQQLYHTVLLMNSAERKKMSGLDEKRVDLIVPGLILVDMIFKLFRLEEIVIAD
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SALREGMVLHYLQQQGSVLKKRGHQESLDIRRESVNELGFRCHWDRGHSEYIARLCLQLF
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
DKLAPLHQLEENYRELLEYSALLHNIGAFISISSHHKHSQYIVMNGELRGFSPSEIAILG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCHHHHHHH
HVVRYHRKSPPSEKHTPYNALKLPHKRAVDVLSGILRIANGLERGHRQNVQNVDVQVKGK
HHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SITMALTCCFEPDIEIWAADQLKAWLETVLQKTIHFQRA
EEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKEALRVAAIDLGTNSFHMIIVEGSRDKGIVEIDRVKDMIGIGHGSIATKMLTEEAMQA
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHH
GIATLKKFLVLAAQHGVQFEHILAFATSAIREAKNRLDFINRVRAETGLKVKIISGKEEA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
EFIYYGVRNAVSVGKTADLIFDIGGGSVEFVLVNHKGVQLLESRKIGVARMHERFVSSDP
CEEEEEHHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCC
IAANDVKMLEQFFAAEMVSAVDKATTMKVRRAVASSGTAETIARMIHAMQGRDSDGALNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
SCFTRSEFQQLYHTVLLMNSAERKKMSGLDEKRVDLIVPGLILVDMIFKLFRLEEIVIAD
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
SALREGMVLHYLQQQGSVLKKRGHQESLDIRRESVNELGFRCHWDRGHSEYIARLCLQLF
HHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
DKLAPLHQLEENYRELLEYSALLHNIGAFISISSHHKHSQYIVMNGELRGFSPSEIAILG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCHHHHHHH
HVVRYHRKSPPSEKHTPYNALKLPHKRAVDVLSGILRIANGLERGHRQNVQNVDVQVKGK
HHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SITMALTCCFEPDIEIWAADQLKAWLETVLQKTIHFQRA
EEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]