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The map label for this gene is accC [H]

Identifier: 78188337

GI number: 78188337

Start: 411656

End: 412999

Strand: Reverse

Name: accC [H]

Synonym: Cag_0359

Alternate gene names: 78188337

Gene position: 412999-411656 (Counterclockwise)

Preceding gene: 78188338

Following gene: 78188324

Centisome position: 16.06

GC content: 47.4

Gene sequence:

>1344_bases
TTGTTCAAAAAAATACTTGTTGCTAATCGTGGCGAAATTGCATTGCGTGTTATGCAAACCTGCCGCGAAATGGGAATCAG
CACCGTTGCCGTTTATTCAACGGTTGATGCTGAATCCATCCACGTAAAATACGCTGATGAGGCGGTCTGTATTGGCCCTG
CACTTTCACGAGAAAGCTACCTCAACATTCCTCGCATTATTGCAGCAGCGGAAGTTACCAATGCCGATGCTATTCATCCC
GGCTACGGCTTTTTAGCTGAAAATGCTGACTTTGCTGAAGTGTGCGCCTCAGCAAACATTAAGTTCATAGGTCCAACAGC
GGCAATGATTAACTCTATGGGCGATAAAAACACCGCGAAAGCCACCATGATTGCGGCTGGTGTGCCCGTAGTTCCCGGCA
GTCCCGGATTGGTAACCGATGCCAAAGATGCGTTAGCAATCGCTAAAAAAATTGGTTACCCCATTATTATTAAGCCAACG
GCTGGCGGTGGTGGAAAAGGAATGCGCGTTGTTACTGAGGATAGCCAGCTTGAAAAAGCTCTCAGCACCGCTCGTAGCGA
AGCTGAGCAAGCCTTTGGCAATAGCGGTGTCTATATTGAAAAGTATTTGGAAAATCCGCGCCATGTGGAAATTCAAATTC
TTTCCGACCAACACGGCAACACTATCCATCTTGGCGAGCGCGATTGCACCGTACAGCGTCGTCATCAAAAGCTTATTGAA
GAGACCCCTTCGCCTGCCGTTGATGAGGCACTTCGCGAAAAAATGGGCACAGCAGCCGTTGCAGCCGCACGCGCTATTAA
TTATGAAGGAGCGGGAACTATTGAATTTTTGCTTGATAAGCATCGCAACTTCTACTTTATGGAGATGAATACCCGTATTC
AGGTAGAGCATCCCGTTACCGAAGAGCGTTATAATGTGGATATTGTCCGAGAGCAAATTTTAATTGCAAATGGGCAGTCC
ATTGCAAACCGCAACTTTACGCCGCAAGGGCATTCCATTGAGTGTCGCATTAATGCCGAAGACCCTGAACACATGTTCCG
TCCCTCACCGGGGCAGTTACAAGTGTTCCACACGCCCGGTGGGCATGGCGTTCGTGTGGACTCTCACGCTTACGCAAGCT
ACGTGGTGCCCTCTAATTACGACTCCATGATTGCAAAGCTAATTGTTACAGCGCACACTCGCGATGAGGCAATTGCACGT
ATGTCGCGAGCCTTAGATGAGTTTATTGTAATGGGCATTAAAACCACCATTCCATTCCACAAACAAGTGATGAACTCTGC
TGTTTTTCAAAGTGGCGATTTCGACACCAGCTTTCTTGAAAGCTTTCACTTTGATAAAAAGTAA

Upstream 100 bases:

>100_bases
TTTCTGGCACCATTGTTGAAATCCTTGTGGAAAATGGACAAGCGGTTGAATACGATCAGCCATTGTTCCGCATTAAACCA
TAATTTTACTTTTTACAGCC

Downstream 100 bases:

>100_bases
ATCCAGTCCAAACTTAAAAGCACCACAATAAAAAAGGGAGACCATATGGCTCCCTTTTTTATTGCATGACATGCCTATGA
GTTCCGATTGCTGAGCACGT

Product: Acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFKKILVANRGEIALRVMQTCREMGISTVAVYSTVDAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCASANIKFIGPTAAMINSMGDKNTAKATMIAAGVPVVPGSPGLVTDAKDALAIAKKIGYPIIIKPT
AGGGGKGMRVVTEDSQLEKALSTARSEAEQAFGNSGVYIEKYLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDEALREKMGTAAVAAARAINYEGAGTIEFLLDKHRNFYFMEMNTRIQVEHPVTEERYNVDIVREQILIANGQS
IANRNFTPQGHSIECRINAEDPEHMFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMNSAVFQSGDFDTSFLESFHFDKK

Sequences:

>Translated_447_residues
MFKKILVANRGEIALRVMQTCREMGISTVAVYSTVDAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCASANIKFIGPTAAMINSMGDKNTAKATMIAAGVPVVPGSPGLVTDAKDALAIAKKIGYPIIIKPT
AGGGGKGMRVVTEDSQLEKALSTARSEAEQAFGNSGVYIEKYLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDEALREKMGTAAVAAARAINYEGAGTIEFLLDKHRNFYFMEMNTRIQVEHPVTEERYNVDIVREQILIANGQS
IANRNFTPQGHSIECRINAEDPEHMFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMNSAVFQSGDFDTSFLESFHFDKK
>Mature_447_residues
MFKKILVANRGEIALRVMQTCREMGISTVAVYSTVDAESIHVKYADEAVCIGPALSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCASANIKFIGPTAAMINSMGDKNTAKATMIAAGVPVVPGSPGLVTDAKDALAIAKKIGYPIIIKPT
AGGGGKGMRVVTEDSQLEKALSTARSEAEQAFGNSGVYIEKYLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
ETPSPAVDEALREKMGTAAVAAARAINYEGAGTIEFLLDKHRNFYFMEMNTRIQVEHPVTEERYNVDIVREQILIANGQS
IANRNFTPQGHSIECRINAEDPEHMFRPSPGQLQVFHTPGGHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMNSAVFQSGDFDTSFLESFHFDKK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=47.1783295711061, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=448, Percent_Identity=47.9910714285714, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=448, Percent_Identity=47.9910714285714, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=449, Percent_Identity=48.1069042316258, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=46.9662921348315, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=29.7619047619048, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=29.7619047619048, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=29.7619047619048, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=29.7619047619048, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=29.7619047619048, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=28.6282306163022, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=56.6591422121896, Blast_Score=474, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17562816, Length=454, Percent_Identity=45.8149779735683, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=45.9276018099548, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.2850678733032, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=30.3643724696356, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=27.7886497064579, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=27.7886497064579, Blast_Score=188, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=41.9642857142857, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=44.1704035874439, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=44.6188340807175, Blast_Score=357, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323863, Length=484, Percent_Identity=30.7851239669421, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=28.3783783783784, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=46.7415730337079, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=46.7415730337079, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=46.7415730337079, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=46.7415730337079, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=46.7415730337079, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.7415730337079, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.7415730337079, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.7415730337079, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.7415730337079, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.7415730337079, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=45.7399103139013, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=44.6341463414634, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=28.6573146292585, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=28.6573146292585, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=28.6573146292585, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=28.6573146292585, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48935; Mature: 48935

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILVANRGEIALRVMQTCREMGISTVAVYSTVDAESIHVKYADEAVCIGPALSRESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCCCCHHH
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCASANIKFIGPTAAMINSMGDKNTAK
CCCCHHEEEHHCCCCCCCCCCCCEEECCCCHHHHHHCCCEEEECCHHHHHHCCCCCCCCC
ATMIAAGVPVVPGSPGLVTDAKDALAIAKKIGYPIIIKPTAGGGGKGMRVVTEDSQLEKA
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHH
LSTARSEAEQAFGNSGVYIEKYLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
HHHHHHHHHHHHCCCCEEEEHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPAVDEALREKMGTAAVAAARAINYEGAGTIEFLLDKHRNFYFMEMNTRIQVEHPVT
HCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCEEEEECCCC
EERYNVDIVREQILIANGQSIANRNFTPQGHSIECRINAEDPEHMFRPSPGQLQVFHTPG
CCCCCHHEEEEEEEEECCCHHHCCCCCCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIARMSRALDEFIVMGIKTTIPFH
CCCEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KQVMNSAVFQSGDFDTSFLESFHFDKK
HHHHHHHHHCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MFKKILVANRGEIALRVMQTCREMGISTVAVYSTVDAESIHVKYADEAVCIGPALSRESY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCCCCCHHH
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCASANIKFIGPTAAMINSMGDKNTAK
CCCCHHEEEHHCCCCCCCCCCCCEEECCCCHHHHHHCCCEEEECCHHHHHHCCCCCCCCC
ATMIAAGVPVVPGSPGLVTDAKDALAIAKKIGYPIIIKPTAGGGGKGMRVVTEDSQLEKA
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHH
LSTARSEAEQAFGNSGVYIEKYLENPRHVEIQILSDQHGNTIHLGERDCTVQRRHQKLIE
HHHHHHHHHHHHCCCCEEEEHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPAVDEALREKMGTAAVAAARAINYEGAGTIEFLLDKHRNFYFMEMNTRIQVEHPVT
HCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCEEEEECCCC
EERYNVDIVREQILIANGQSIANRNFTPQGHSIECRINAEDPEHMFRPSPGQLQVFHTPG
CCCCCHHEEEEEEEEECCCHHHCCCCCCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GHGVRVDSHAYASYVVPSNYDSMIAKLIVTAHTRDEAIARMSRALDEFIVMGIKTTIPFH
CCCEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KQVMNSAVFQSGDFDTSFLESFHFDKK
HHHHHHHHHCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]