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The map label for this gene is gpmA

Identifier: 78188170

GI number: 78188170

Start: 214160

End: 214903

Strand: Reverse

Name: gpmA

Synonym: Cag_0187

Alternate gene names: 78188170

Gene position: 214903-214160 (Counterclockwise)

Preceding gene: 78188173

Following gene: 78188169

Centisome position: 8.36

GC content: 45.56

Gene sequence:

>744_bases
ATGATCAAACTTGTATTACTGCGCCACGGCGAAAGCCAATGGAACCGTGAAAATCGCTTTACTGGCTGGCACGATATTGA
TTTAACTGACCAAGGGCGCATAGAAGCCTCAAATGCTGGCAAGTTGCTCCGTGCCGAAGGCTTTACTTTTGATATTGCTT
ACACCTCCGTGCTCAAGCGTGCCATTAGAACCTTATGGCATGTATTGGATGAAATGGATTTGATGTGGCTACCTGTTACC
AAAAGCTGGCGTTTAAATGAGCGCCATTACGGTGCCTTGCAAGGCTTAAACAAAGCGGAAACCGCACAAAAATATGGCGA
AGAACAGGTGCTTGTGTGGCGCCGTAGCTACGACACCCCACCTCCAGCACTTGAAAAAAGTGATGCTCGTTACCCCGGCT
CTCAAGCTCGCTATGCAAGTTTAAGCGAAGCTGAAGTTCCGCTTACTGAATGTTTAAAAGATACCGTTGCTCGTTTTCTG
CCTCTTTGGCACGAAACCATTGCACCCGAAATTCGCAAAGGGCGCAACGTTATTATTGCGGCTCACGGCAACTCTATTCG
TGCATTGGTAAAATATCTTGATAATGTGTCGGAAGATGATATTGTAGGAATTAATATTCCAACGGGTATTCCGTTGGTGT
ATGAATTAGATGATGATCTCAAGCCAATTCGCAGCTACTACCTTGGCGATCAAGATGCACTGAAAAAAGCACAAGAAGCC
GTTGCAAAACAAGGAAAAGCGTAA

Upstream 100 bases:

>100_bases
GAAGCTTAGGATTTGAGAAAAGATAGAGATAATATTAAATTGGCGCCCAAAAACAGCGGAGCAACGCCATTTTTCAGAAT
CGAACTTTAAAGCTGCAACT

Downstream 100 bases:

>100_bases
AACAAAACGGCAGGCTTGTAGCAAAGTTGTAAAGGCATTAGGTATTCCATTACATAGCAATACGCCAATGGATACCGAAT
GCCCTTTTGAAATTCTTTTT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MIKLVLLRHGESQWNRENRFTGWHDIDLTDQGRIEASNAGKLLRAEGFTFDIAYTSVLKRAIRTLWHVLDEMDLMWLPVT
KSWRLNERHYGALQGLNKAETAQKYGEEQVLVWRRSYDTPPPALEKSDARYPGSQARYASLSEAEVPLTECLKDTVARFL
PLWHETIAPEIRKGRNVIIAAHGNSIRALVKYLDNVSEDDIVGINIPTGIPLVYELDDDLKPIRSYYLGDQDALKKAQEA
VAKQGKA

Sequences:

>Translated_247_residues
MIKLVLLRHGESQWNRENRFTGWHDIDLTDQGRIEASNAGKLLRAEGFTFDIAYTSVLKRAIRTLWHVLDEMDLMWLPVT
KSWRLNERHYGALQGLNKAETAQKYGEEQVLVWRRSYDTPPPALEKSDARYPGSQARYASLSEAEVPLTECLKDTVARFL
PLWHETIAPEIRKGRNVIIAAHGNSIRALVKYLDNVSEDDIVGINIPTGIPLVYELDDDLKPIRSYYLGDQDALKKAQEA
VAKQGKA
>Mature_247_residues
MIKLVLLRHGESQWNRENRFTGWHDIDLTDQGRIEASNAGKLLRAEGFTFDIAYTSVLKRAIRTLWHVLDEMDLMWLPVT
KSWRLNERHYGALQGLNKAETAQKYGEEQVLVWRRSYDTPPPALEKSDARYPGSQARYASLSEAEVPLTECLKDTVARFL
PLWHETIAPEIRKGRNVIIAAHGNSIRALVKYLDNVSEDDIVGINIPTGIPLVYELDDDLKPIRSYYLGDQDALKKAQEA
VAKQGKA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=248, Percent_Identity=56.0483870967742, Blast_Score=300, Evalue=5e-82,
Organism=Homo sapiens, GI4505753, Length=248, Percent_Identity=59.6774193548387, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI71274132, Length=248, Percent_Identity=57.258064516129, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4502445, Length=250, Percent_Identity=48.4, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI40353764, Length=250, Percent_Identity=48.4, Blast_Score=255, Evalue=3e-68,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=61.4906832298137, Blast_Score=193, Evalue=1e-49,
Organism=Escherichia coli, GI1786970, Length=247, Percent_Identity=65.587044534413, Blast_Score=345, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=49.1869918699187, Blast_Score=241, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6324516, Length=286, Percent_Identity=32.1678321678322, Blast_Score=148, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6320183, Length=299, Percent_Identity=32.1070234113712, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646216, Length=249, Percent_Identity=52.2088353413655, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI85725270, Length=249, Percent_Identity=53.0120481927711, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI85725272, Length=249, Percent_Identity=53.0120481927711, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24650981, Length=249, Percent_Identity=53.0120481927711, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI28571815, Length=249, Percent_Identity=39.3574297188755, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=39.3574297188755, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571817, Length=249, Percent_Identity=39.3574297188755, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_CHLCH (Q3AU60)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378508.1
- ProteinModelPortal:   Q3AU60
- SMR:   Q3AU60
- STRING:   Q3AU60
- GeneID:   3747713
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0187
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   CCHL340177:CAG_0187-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28127; Mature: 28127

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLVLLRHGESQWNRENRFTGWHDIDLTDQGRIEASNAGKLLRAEGFTFDIAYTSVLKR
CEEEEEEECCCHHCCCCCCCCCCEECCCCCCCCEECCCCCCEEEECCCEEEHHHHHHHHH
AIRTLWHVLDEMDLMWLPVTKSWRLNERHYGALQGLNKAETAQKYGEEQVLVWRRSYDTP
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCC
PPALEKSDARYPGSQARYASLSEAEVPLTECLKDTVARFLPLWHETIAPEIRKGRNVIIA
CCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEE
AHGNSIRALVKYLDNVSEDDIVGINIPTGIPLVYELDDDLKPIRSYYLGDQDALKKAQEA
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHH
VAKQGKA
HHHCCCC
>Mature Secondary Structure
MIKLVLLRHGESQWNRENRFTGWHDIDLTDQGRIEASNAGKLLRAEGFTFDIAYTSVLKR
CEEEEEEECCCHHCCCCCCCCCCEECCCCCCCCEECCCCCCEEEECCCEEEHHHHHHHHH
AIRTLWHVLDEMDLMWLPVTKSWRLNERHYGALQGLNKAETAQKYGEEQVLVWRRSYDTP
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCC
PPALEKSDARYPGSQARYASLSEAEVPLTECLKDTVARFLPLWHETIAPEIRKGRNVIIA
CCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEE
AHGNSIRALVKYLDNVSEDDIVGINIPTGIPLVYELDDDLKPIRSYYLGDQDALKKAQEA
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHH
VAKQGKA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA