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The map label for this gene is prs [H]

Identifier: 78067601

GI number: 78067601

Start: 3276278

End: 3277240

Strand: Direct

Name: prs [H]

Synonym: Bcep18194_A6132

Alternate gene names: 78067601

Gene position: 3276278-3277240 (Clockwise)

Preceding gene: 78067600

Following gene: 78067602

Centisome position: 88.69

GC content: 62.51

Gene sequence:

>963_bases
ATGAGCAGCCACAGCCATGATGGCCTGATGGTCTTTACTGGCAACGCGAATCCCGCGCTCGCCCAGGAAGTCGTCAATAT
CCTTGGAATCCCCCTCGGCAAAGCAATGGTCAGCCGTTTCTCCGACGGCGAGATCCAGGTCGAGATCCAGGAAAACGTGC
GCGGCAAGGACGTCTTCGTCCTGCAATCCACGTGCGCGCCGACGAACGACAACCTGATGGAACTGATGATCATGGTCGAT
GCGCTCAAGCGCGCATCCGCTGGCCGGATCACTGCTGCCATCCCCTACTTCGGCTACGCCCGTCAGGATCGCCGCCCGCG
TTCGGCGCGTGTCGCGATCTCGGCGAAGGTCGTCGCGAACATGCTGGAAATCGCCGGCGTCGAGCGGATCATCACGATGG
ATCTGCACGCCGACCAGATTCAGGGCTTCTTCGACATCCCGGTCGACAACATCTACGCAACGCCGATCCTGCTGGGTGAC
CTGCGCAAGCAGAACTACTCGGATCTGCTCGTCGTGTCGCCGGACGTCGGCGGCGTGGTACGTGCCCGGGCACTCGCGAA
ACAGCTCAACTGCGATCTCGCGATCATCGACAAGCGTCGCCCGAAGGCGAACGTCTCCGAAGTGATGAACATCATCGGTG
AAGTCGAAGGTCGCACCTGCGTGATCATGGACGACATGGTCGATACGGCAGGCACGCTCTGCAAGGCCGCGCAAGTGCTG
AAGGAACGCGGCGCGAAGCAGGTCTTCGCGTACGCCACGCACCCGGTGCTGTCGGGTGGCGCTGGTGATCGAATCGCCGC
ATCGGCGCTCGACGAACTGGTCGTCACCGATACGATCCCGCTGTCCGCCGAATCGCTCGGCTGCTCGAAGATCCGTGCGT
TGACGAGCGCGAGCCTGCTGGCCGAAACGTTCTCGCGGATCCGCCGCGGCGACTCGGTGATGTCGCTGTTCGCGGAATCC
TGA

Upstream 100 bases:

>100_bases
AGGCACCGGATTTTGATTCCGGCATGCGAGGGTTCGAGTCCTTCCTCCCCTGCCAAAAATTTTTCCCGCATTTCCCGCCC
AAGCCTGAAGCAGGTGCACG

Downstream 100 bases:

>100_bases
TCGCGAATCGACTGAACAAAGCATGCGCAGAAAGCGAAGCGGCAACGCTTCGCTTTTTGCACAATCGGACGGGATAGACG
AAACCCCGGCCGTTTCATCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVSEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KERGAKQVFAYATHPVLSGGAGDRIAASALDELVVTDTIPLSAESLGCSKIRALTSASLLAETFSRIRRGDSVMSLFAES

Sequences:

>Translated_320_residues
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVSEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KERGAKQVFAYATHPVLSGGAGDRIAASALDELVVTDTIPLSAESLGCSKIRALTSASLLAETFSRIRRGDSVMSLFAES
>Mature_319_residues
SSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVSEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
ERGAKQVFAYATHPVLSGGAGDRIAASALDELVVTDTIPLSAESLGCSKIRALTSASLLAETFSRIRRGDSVMSLFAES

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=47.4522292993631, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=47.7707006369427, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=47.7707006369427, Blast_Score=298, Evalue=4e-81,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=46.8354430379747, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.7052023121387, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=36.8115942028986, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=63.8709677419355, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=46.8152866242038, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=46.8152866242038, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=47.2668810289389, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=46.8152866242038, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=319, Percent_Identity=42.6332288401254, Blast_Score=262, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=300, Percent_Identity=46, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=42.7672955974843, Blast_Score=259, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=43.3673469387755, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=39.8148148148148, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=47.6038338658147, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=44.4776119402985, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24651458, Length=362, Percent_Identity=33.4254143646409, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24651456, Length=362, Percent_Identity=33.4254143646409, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI281362873, Length=362, Percent_Identity=33.4254143646409, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651454, Length=362, Percent_Identity=33.4254143646409, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651462, Length=210, Percent_Identity=37.6190476190476, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24651464, Length=210, Percent_Identity=37.6190476190476, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552010, Length=210, Percent_Identity=37.6190476190476, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34433; Mature: 34302

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVSEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KERGAKQVFAYATHPVLSGGAGDRIAASALDELVVTDTIPLSAESLGCSKIRALTSASLL
HHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SSHSHDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVSEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KERGAKQVFAYATHPVLSGGAGDRIAASALDELVVTDTIPLSAESLGCSKIRALTSASLL
HHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]