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The map label for this gene is hexR [H]

Identifier: 78067538

GI number: 78067538

Start: 3211457

End: 3212395

Strand: Reverse

Name: hexR [H]

Synonym: Bcep18194_A6069

Alternate gene names: 78067538

Gene position: 3212395-3211457 (Counterclockwise)

Preceding gene: 78067541

Following gene: 78067537

Centisome position: 86.96

GC content: 70.18

Gene sequence:

>939_bases
ATGAATACGCCCGCCACTCCGTCCGTCCCGCTCGCGGCCGAGCTTCATCCGGCTCCGGCCGCACCGCCGGTCCTCGACAT
CGTCGCGCGGATCGCCGAATGCGCGCCCGAACTGCGCGAAGCCGAGCGCAAGGTCGCCGCGTTCATCCTCGCCGACCTGG
CGCGCGCCGCGCATGCCAGCATCGGCGCGCTGGCACGCGACGCGGAGGTCAGCGTCGCGACGGTCACGCGTTTCGCGAAA
GCGGTCGGCTGCCGCGACGTGCGCGAACTGAAGGTGCTGGTCGCGCAGGCGGCGGCCGTCGGCCAGCGCTTCCTGGTGCC
GTCCGACGACGCGCCGGCCGACGACCCGAGCCCCGCGTCGATGGTCTACGACGAGATCCGCCTGGCGCTCGCGCACAACC
ATCAGTTGCTGCGCAATACGTCGTTCGAGGCGGCGGCCGACCTGCTCGCCGCCGCGAAGATGACCTATGTGTACGGCCAG
GGCGGCGGCTCGACCGCGCTTGCCGACGAGCTGCGCTTCCGGCTGGTGCGTTTCGGCCGGCCGGTCGCGAGCTATCAGGA
CAGCGTGCTGCAGCGAATGGTGGCCGCGACGCTGTCGCGCGACACCGTCGTGGTCGCGCTGTCGGTGAGCGGCCGCGTGC
CCGAGCTGCTCGAGAGCTGCCGGCTCGCGAAGCGCTACGGCGCGAAGCTGATCGCGATTACCGCGCCGGCGTCGCCGCTC
GCGAAGCTGGCCGACCACCTGATCCCGGTCGTCGCGTTCGAAACCGATTTCATTTACAAGCCGTCGACATCGCGTTACGC
GATGATGATGGCGATCGACGTGCTCGTCACCGGAGTCGCATTGCGGCTCGGCGATGCGGGCCGAGAATCGCTGCGTCGCA
TCAAGCACGCGCTCGATGCGCATCGCGGCGGCGGAGACCGTCAACCGGTAGGAGACTGA

Upstream 100 bases:

>100_bases
ACTATGCATTGCACTGAAGTTGACACGCCGATGGTACAGAAAGTAGCATCGGCGCGGTGATGTTATTTAGTAACATCGAG
CTTCACACCTTTTTCCGCAG

Downstream 100 bases:

>100_bases
CCATGCATTCGCATCCCGAAGCCGCCGATACGCTGATCGTCGGCGCGCAGCTTTACGACGGTACCGGCGCGCCGCCCGTC
ACGCGCGACGTCGCGATCCG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNTPATPSVPLAAELHPAPAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDPSPASMVYDEIRLALAHNHQLLRNTSFEAAADLLAAAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSVLQRMVAATLSRDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Sequences:

>Translated_312_residues
MNTPATPSVPLAAELHPAPAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDPSPASMVYDEIRLALAHNHQLLRNTSFEAAADLLAAAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSVLQRMVAATLSRDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD
>Mature_312_residues
MNTPATPSVPLAAELHPAPAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDPSPASMVYDEIRLALAHNHQLLRNTSFEAAADLLAAAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSVLQRMVAATLSRDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=281, Percent_Identity=35.5871886120996, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1788767, Length=278, Percent_Identity=26.978417266187, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI87082369, Length=248, Percent_Identity=26.2096774193548, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 33131; Mature: 33131

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPATPSVPLAAELHPAPAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHAS
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDAEVSVATVTRFAKAVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDPSPAS
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
MVYDEIRLALAHNHQLLRNTSFEAAADLLAAAKMTYVYGQGGGSTALADELRFRLVRFGR
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCC
PVASYQDSVLQRMVAATLSRDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
CHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHH
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDA
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HRGGGDRQPVGD
HCCCCCCCCCCC
>Mature Secondary Structure
MNTPATPSVPLAAELHPAPAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHAS
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDAEVSVATVTRFAKAVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDPSPAS
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
MVYDEIRLALAHNHQLLRNTSFEAAADLLAAAKMTYVYGQGGGSTALADELRFRLVRFGR
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCC
PVASYQDSVLQRMVAATLSRDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
CHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHH
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDA
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HRGGGDRQPVGD
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]