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The map label for this gene is fadA [H]

Identifier: 78067515

GI number: 78067515

Start: 3184623

End: 3185822

Strand: Reverse

Name: fadA [H]

Synonym: Bcep18194_A6046

Alternate gene names: 78067515

Gene position: 3185822-3184623 (Counterclockwise)

Preceding gene: 78067516

Following gene: 78067514

Centisome position: 86.24

GC content: 66.92

Gene sequence:

>1200_bases
ATGAGCAAACAATTGCAAGACGCATACATCGTCGCCGCCAGCCGCACGCCGATCGGCAAGGCCCCGCGCGGTGTCTTCAA
GAACACGCGCCCGGACGAGCTGCTGGTCCACGCGCTGAAGTCGGCGGTGGCGCAGGTGCCGGGCTTCGACACGAAGCTGA
TCGAAGACGCGATCATCGGTTGCGCGATTCCGGAAGCCGAGCAGGGCCTGAACGTCGCGCGGATGGGTGCGCTGCTCGCA
GGCCTGCCGCAGACGGTCGGCGGCGTGACGGTCAACCGCTTCTGCGCGTCGGGCATCACGGCGCTGGCCATGGCGGCCGA
CCGCATTCGCGTCGGCGAATCGGACGCGATCTTCGCGGGTGGTTGCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGATCGCAATGAAGACTTCGGCATCGCGTACGGGATGGGCCTGACGGCCGAGCGC
GTCGCGGAGCAATGGAAGGTTAGCCGCGAAGACCAGGACGCGTTCTCGGTCGAGTCGCACCGCAAGGCGCTTGCCGCCCA
GCAGGCTGGCGAGTTCAACGACGAGATCGCCGCGTACACGATCACCGAGCGTTTCCCGAACCTCGCGACGGGTGAAGTCG
ACGTGAAGACGCGCGAGATCGCGCTCGACGAAGGTCCGCGTGCGGATACGTCGATCGAAGGCCTCGCGAAGCTGCGCACG
GTGTTCGCGAACAAGGGCTCGGTCACGGCCGGCAACAGCTCGCAGACGTCGGACGGCGCGGGCGCGCTGCTCGTCGTGTC
GGAGAAGGTGCTCAAGGAATTCAACCTGACGCCGCTCGCGCGCTTCGTGAGCTTCGCGGTGCGTGGCGTGCCGCCGGAAA
TCATGGGCATCGGTCCGAAGGAAGCGATTCCGGCCGCGCTGAAGGCCGCCGGCCTGAAGCAGGACGATCTCGACTGGATC
GAGCTGAACGAAGCGTTCGCCGCGCAATCGCTGGCGGTGATGCGCGATCTCGGCCTCGACCCGTCGAAGGTCAACCCGAT
GGGCGGCGCGATCGCACTCGGCCACCCGCTCGGCGCGACCGGCGCGATCCGCGCGGCGACCGTCGTGCACGGCCTGCGTC
GCCGTAACCTGAAGTACGGGATGGTCACGATGTGCGTCGGCACCGGCATGGGCGCCGCAGGCATCATCGAACGCCTGTAA

Upstream 100 bases:

>100_bases
GCTGCTCGGCACGCAGAAGACGCAGGAACGGATCATGGGCATGTTGCAGACCGGCAAGCCGGTGCGTAACTGAGCGAGCG
GATAAGGCAAGGAGTCTCAA

Downstream 100 bases:

>100_bases
GCGGAGCGGGACAAGAGCGACGACGGTGCGCGGGCCACGAGCTCGCGCACCGTTTTTTCATTCCGATAGAGGAAAGTCAA
AGGAGACGGTTGTGGCCGAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHALKSAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRNEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKALAAQQAGEFNDEIAAYTITERFPNLATGEVDVKTREIALDEGPRADTSIEGLAKLRT
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHALKSAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLA
GLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRNEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKALAAQQAGEFNDEIAAYTITERFPNLATGEVDVKTREIALDEGPRADTSIEGLAKLRT
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWI
ELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHALKSAVAQVPGFDTKLIEDAIIGCAIPEAEQGLNVARMGALLAG
LPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAGGCESMSMVPMMGNKPSMSPHIFDRNEDFGIAYGMGLTAERV
AEQWKVSREDQDAFSVESHRKALAAQQAGEFNDEIAAYTITERFPNLATGEVDVKTREIALDEGPRADTSIEGLAKLRTV
FANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDLDWIE
LNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.6224489795918, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=39.0663390663391, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI148539872, Length=341, Percent_Identity=40.4692082111437, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=33.1632653061224, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=30.2272727272727, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=43.6893203883495, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=42.0792079207921, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.9014778325123, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.6039603960396, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1788683, Length=380, Percent_Identity=31.8421052631579, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=42.0398009950249, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=36.6093366093366, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.8358208955224, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=30.1123595505618, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=29.9748110831234, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=40.547263681592, Blast_Score=275, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=39.3120393120393, Blast_Score=235, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=38.9162561576355, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=39.7058823529412, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.7408312958435, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.9004524886878, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42018; Mature: 41887

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHALKSAVAQVPGFDTKLIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFNDEIAAYTITERFPNLATGEVDVKTREIALDEGPRADTSIEGLAKLRT
HHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGVFKNTRPDELLVHALKSAVAQVPGFDTKLIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPQTVGGVTVNRFCASGITALAMAADRIRVGESDAIFAG
CCCCCHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKALAAQQAGEFNDEIAAYTITERFPNLATGEVDVKTREIALDEGPRADTSIEGLAKLRT
HHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALLVVSEKVLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHHCCCCH
EAIPAALKAAGLKQDDLDWIELNEAFAAQSLAVMRDLGLDPSKVNPMGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]