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The map label for this gene is fadA [H]

Identifier: 78066674

GI number: 78066674

Start: 2251766

End: 2252944

Strand: Reverse

Name: fadA [H]

Synonym: Bcep18194_A5205

Alternate gene names: 78066674

Gene position: 2252944-2251766 (Counterclockwise)

Preceding gene: 78066675

Following gene: 78066673

Centisome position: 60.99

GC content: 68.11

Gene sequence:

>1179_bases
ATGACCGAAGCCGTAATCGTATCGACCGCCCGCACGCCGCTGGCGAAATCCTGGCGCGGTGCTTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCACGCGGTCGCGGCCGCGCTCGAACGCTCGAAGCTCGACCCCGCACGCGTCGAGGACGTGATCA
TGGGTTGCGCGAACCCCGAAGGCGCGACCGGCGCGAACATCGCGCGGCAGATCGCACTGCGCGCGGGGCTGCCCGTGACG
GTGCCGGGGATGACCGTGAACCGTTTCTGCTCGTCCGGGCTGCAGACCATCGCACTGGCCGCGCAGCGGATCATCGCCGG
TGAAGGCGAAGTGTATGTGGCGGGCGGTGTCGAATCGATCTCGTGCGTGCAGAACGAGATGAACCACCACATGATCCAGG
AAGGCTGGCTCGTCCAGCACAAGCCCGAGATCTACTGGAACATGCTGCAGACCGCCGAGAACGTCGCGAAGCGCTACGGC
ATCTCGAAGGAGCGGCAGGACGAGTACGGCGTGCAGTCGCAACTGCGGGCCGCGGCCGCGCAGGAAGCCGGGCGCTTCCG
CGACGAGATCGCGCCGATCACCGTGCTCGCGGGCCTCGCCGACAAGGCAACGGGCCGCCTGTTCACGAAGGAAGTGACGG
TCTCGGCCGACGAAGGGATCCGCCCCGACACGACGCTCGAAGGCGTGTCGAAGATCCGGTCGGCCGTGCCGGGTGGCGTG
ATCACCGCCGGCAACGCGAGCCAGTTCTCGGACGGCGCGTCGGCCTGCGTCGTGATGAGCGCCGACGCCGCGCAGCGCGA
AGGGCTGCAGCCGCTCGGCGTGTTCCGCGGCTTCGCGGTGGCCGGGTGCGAGCCGGACGAGATGGGCATCGGTCCCGTGT
TCGCGGTCCCCAAGCTGCTGAAGCAGGCAGGGCTGAAGGTCGACGATATCGGCCTGTGGGAATTGAACGAAGCGTTCGCG
GTGCAGGTGCTGTACTGCCGCGACACGCTCGGGATTCCTGAGGATCGACTGAACGTGAACGGCGGCGCGATCGCGGTCGG
CCATCCGTACGGCGTATCGGGCGCACGCCTGACGGGCCATGCGCTGATCGAAGGCAAGCGACGCGGCGTGAAGTACGTGG
TCGTCACGATGTGCATCGGCGGCGGGCAGGGCGCAGCCGGCCTGTTCGAAATCCTCTGA

Upstream 100 bases:

>100_bases
CAGCGGGCGTCGCGCATGTGACGTCCGCGGGCGCGCGCCCGCAGGCGTAGCGCATTCCCCATCCGATTCAGGACATGATG
CAGGACCGAAGGAGACTCGC

Downstream 100 bases:

>100_bases
TCTTTGGCAGATGGCGGCCGCGGTTTCGCTTCGGCGAGGCAGGCGGCCGCGACGCGAATCGGTGCGACTGAACCACCATT
CGAAACAATCGGGAAGCAAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHAVAAALERSKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVT
VPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNHHMIQEGWLVQHKPEIYWNMLQTAENVAKRYG
ISKERQDEYGVQSQLRAAAAQEAGRFRDEIAPITVLAGLADKATGRLFTKEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
ITAGNASQFSDGASACVVMSADAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFA
VQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEIL

Sequences:

>Translated_392_residues
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHAVAAALERSKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVT
VPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNHHMIQEGWLVQHKPEIYWNMLQTAENVAKRYG
ISKERQDEYGVQSQLRAAAAQEAGRFRDEIAPITVLAGLADKATGRLFTKEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
ITAGNASQFSDGASACVVMSADAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFA
VQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEIL
>Mature_391_residues
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHAVAAALERSKLDPARVEDVIMGCANPEGATGANIARQIALRAGLPVTV
PGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESISCVQNEMNHHMIQEGWLVQHKPEIYWNMLQTAENVAKRYGI
SKERQDEYGVQSQLRAAAAQEAGRFRDEIAPITVLAGLADKATGRLFTKEVTVSADEGIRPDTTLEGVSKIRSAVPGGVI
TAGNASQFSDGASACVVMSADAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIGLWELNEAFAV
QVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEIL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=43.4782608695652, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=40.0503778337531, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=37.1287128712871, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=35.264483627204, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=30.184331797235, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.133676092545, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=40.6565656565657, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=41.0194174757282, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=408, Percent_Identity=41.1764705882353, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=38.0597014925373, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=29.0476190476191, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.8471177944862, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=38.1773399014778, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=33.9195979899498, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=29.9086757990868, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=28.9002557544757, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.8686868686869, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=32.5062034739454, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.5, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=40.2234636871508, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24640423, Length=407, Percent_Identity=35.8722358722359, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=31.1778290993072, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41163; Mature: 41031

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSTARTPLAKSWRGAFNMTHGATLGGHAVAAALERSKLDPARVEDVIMGCANPE
CCCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGLPVTVPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESI
CCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMIQEGWLVQHKPEIYWNMLQTAENVAKRYGISKERQDEYGVQSQLRAAAA
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QEAGRFRDEIAPITVLAGLADKATGRLFTKEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
HHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSADAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVDDIGLWELNEAFAVQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCCEECCCCCEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEIL
HEECCCCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
TEAVIVSTARTPLAKSWRGAFNMTHGATLGGHAVAAALERSKLDPARVEDVIMGCANPE
CCEEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGLPVTVPGMTVNRFCSSGLQTIALAAQRIIAGEGEVYVAGGVESI
CCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMIQEGWLVQHKPEIYWNMLQTAENVAKRYGISKERQDEYGVQSQLRAAAA
HHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QEAGRFRDEIAPITVLAGLADKATGRLFTKEVTVSADEGIRPDTTLEGVSKIRSAVPGGV
HHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMSADAAQREGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHCCCEEECCCCCCCCCCHHHHHHHHH
KQAGLKVDDIGLWELNEAFAVQVLYCRDTLGIPEDRLNVNGGAIAVGHPYGVSGARLTGH
HHCCCCEECCCCEECCCCCEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEIL
HEECCCCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]