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The map label for this gene is nuoF2 [H]

Identifier: 78065617

GI number: 78065617

Start: 1078954

End: 1080531

Strand: Reverse

Name: nuoF2 [H]

Synonym: Bcep18194_A4145

Alternate gene names: 78065617

Gene position: 1080531-1078954 (Counterclockwise)

Preceding gene: 78065618

Following gene: 78065616

Centisome position: 29.25

GC content: 69.26

Gene sequence:

>1578_bases
ATGACGACCCGCATCTACGTCCCGCGCGACTCGTCCGCACTGGCGCTCGGCGCCGACGCGCTCGCCGCCGCGATTGCTGC
GGAAGCCGAACGGCGCGGCGTCGCCGTCGAACTGGTCCGCAACGGTTCGCGCGGGCTGCTGTGGCTCGAGCCGCTCGTCG
AGGTCGGCACGGCCGCCGGCCGCGTCGGCTATGCGAACCTGTCGGCCGCCGACGTGCTGGCCCTGTTCGACGCAAACTGG
CTCGAAGGCGGCGCGCATCCGAGCGGTGTCGGCCTCGTCGACGCACTGCCCTATCTCGCACGCCAGCAGCGCCTCACGTT
CGCGCGCATCGGCCTGACCGATCCGCTGTCGATCGACGACTACCTGCAATACGAAGGCCTCGCCGGCTTGAAGAACGTCC
TCGCGCTCGACGGCGATGCCGTATGCGAAGCGCTGATCGAATCGGGGTTGCGCGGCCGCGGTGGCGCGGCGTTCCCGGCC
GGCATCAAGTGGCGCACGGTCCGGCAAGCGAGCGCCACGCAGAAGTACATCGTCTGCAATGCAGACGAAGGCGATTCGGG
CACGTTCTCCGACCGCCTGATCATGGAGTGCGATCCGTACTGCCTGATCGAAGGGATGATCATCGCGGGCGTCGCGACCG
GCGCGACGGTCGGCTACATCTACGTGCGCAGCGAATACCCGCATGCGATCGCGACGCTCGAAGCCGCGATCGTCCGCGCA
CGCGAAGCCGGCTGGCTCGGCGAGCACGTGCTCGGCTCCGCACATGCGTTCGAGCTGCACGTCGCGAAAGGCGCGGGCTC
GTACGTGTGCGGCGAGGAAACGGCGCTGCTCGAATCGCTCGAAGGCAAGCGCGGCGTCGTGCGTGCGAAACCGCCACTGC
CCGCGCTCGCCGGCCTGTACGGCCAGCCGACCGTCATCAACAACGTGATCACGCTCGCGACGGCGCCCGTGATATTCGCG
CGCGGCGCCGCGTTCTATCGCGACTACGGGATGGGCCGCTCGCGCGGCACGCTGCCGTTCCAGCTCGCGGGCAACATCCG
CCACGGCGGCCTGGTCGAGCTCTCGTTCGGCGTCACGCTGCGCGAGCTGCTGTTCGATTTCGGCGGCGGCACGGCAAGCG
GCCGGCCCGCACGTGCGGCGCAGGTGGGCGGCCCGCTCGGCACCTACCTGCCCGATCACCAGTGGGACGTGCCGCTCGAC
TACGAAGCGTATACGGCGATCGGCGCGGTGGTCGGCCACGGCGGCATCGTGCTGCACGACGACACGTCGAACCTCGCCGA
GCTGGCCGAATACTCGATGAAGTTCTGCGCGATCGAGTCGTGCGGCAAGTGCACGCCGTGCCGGATCGGTTCGACACGTG
GTGTCGAGACGATCGCGCGCATCCGCGACGGCGACACGTCGGAGCGGCAGGTCACGCTGCTGCGCGACCTGTGCGACACG
ATGCTGGCCGGTTCGCTATGCGCAATGGGCGGCATGACACCCTACCCGGTGCTGTCCGCGCTCGACCATTTCCCCGAAGA
TTTCGGGCTCGCTGCCGGCAAAGATGCCGCGTCGGGTCCGGTCAAGGCTGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCCGTCGCTAACGGTCAACGGCGTGCTGCATGCCAGGGTCACGCCGGAGAAATTCGACGCGCTGCTTGCCGAGGCCGCC
GCCCACACCCCGGAGGCCGC

Downstream 100 bases:

>100_bases
CCCAGAAGGAGCCCTGCATGTCCCTCGACACGAACAACGTCCGCCAAGGCGGCTGCGGCTCGGGCCAATGCGCGTGCAAG
AGCGCCGCGCAGGCGCGTGC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTTRIYVPRDSSALALGADALAAAIAAEAERRGVAVELVRNGSRGLLWLEPLVEVGTAAGRVGYANLSAADVLALFDANW
LEGGAHPSGVGLVDALPYLARQQRLTFARIGLTDPLSIDDYLQYEGLAGLKNVLALDGDAVCEALIESGLRGRGGAAFPA
GIKWRTVRQASATQKYIVCNADEGDSGTFSDRLIMECDPYCLIEGMIIAGVATGATVGYIYVRSEYPHAIATLEAAIVRA
REAGWLGEHVLGSAHAFELHVAKGAGSYVCGEETALLESLEGKRGVVRAKPPLPALAGLYGQPTVINNVITLATAPVIFA
RGAAFYRDYGMGRSRGTLPFQLAGNIRHGGLVELSFGVTLRELLFDFGGGTASGRPARAAQVGGPLGTYLPDHQWDVPLD
YEAYTAIGAVVGHGGIVLHDDTSNLAELAEYSMKFCAIESCGKCTPCRIGSTRGVETIARIRDGDTSERQVTLLRDLCDT
MLAGSLCAMGGMTPYPVLSALDHFPEDFGLAAGKDAASGPVKAAA

Sequences:

>Translated_525_residues
MTTRIYVPRDSSALALGADALAAAIAAEAERRGVAVELVRNGSRGLLWLEPLVEVGTAAGRVGYANLSAADVLALFDANW
LEGGAHPSGVGLVDALPYLARQQRLTFARIGLTDPLSIDDYLQYEGLAGLKNVLALDGDAVCEALIESGLRGRGGAAFPA
GIKWRTVRQASATQKYIVCNADEGDSGTFSDRLIMECDPYCLIEGMIIAGVATGATVGYIYVRSEYPHAIATLEAAIVRA
REAGWLGEHVLGSAHAFELHVAKGAGSYVCGEETALLESLEGKRGVVRAKPPLPALAGLYGQPTVINNVITLATAPVIFA
RGAAFYRDYGMGRSRGTLPFQLAGNIRHGGLVELSFGVTLRELLFDFGGGTASGRPARAAQVGGPLGTYLPDHQWDVPLD
YEAYTAIGAVVGHGGIVLHDDTSNLAELAEYSMKFCAIESCGKCTPCRIGSTRGVETIARIRDGDTSERQVTLLRDLCDT
MLAGSLCAMGGMTPYPVLSALDHFPEDFGLAAGKDAASGPVKAAA
>Mature_524_residues
TTRIYVPRDSSALALGADALAAAIAAEAERRGVAVELVRNGSRGLLWLEPLVEVGTAAGRVGYANLSAADVLALFDANWL
EGGAHPSGVGLVDALPYLARQQRLTFARIGLTDPLSIDDYLQYEGLAGLKNVLALDGDAVCEALIESGLRGRGGAAFPAG
IKWRTVRQASATQKYIVCNADEGDSGTFSDRLIMECDPYCLIEGMIIAGVATGATVGYIYVRSEYPHAIATLEAAIVRAR
EAGWLGEHVLGSAHAFELHVAKGAGSYVCGEETALLESLEGKRGVVRAKPPLPALAGLYGQPTVINNVITLATAPVIFAR
GAAFYRDYGMGRSRGTLPFQLAGNIRHGGLVELSFGVTLRELLFDFGGGTASGRPARAAQVGGPLGTYLPDHQWDVPLDY
EAYTAIGAVVGHGGIVLHDDTSNLAELAEYSMKFCAIESCGKCTPCRIGSTRGVETIARIRDGDTSERQVTLLRDLCDTM
LAGSLCAMGGMTPYPVLSALDHFPEDFGLAAGKDAASGPVKAAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=380, Percent_Identity=37.3684210526316, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI260656005, Length=380, Percent_Identity=37.3684210526316, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1788620, Length=398, Percent_Identity=38.6934673366834, Blast_Score=287, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17531727, Length=420, Percent_Identity=36.4285714285714, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI19920794, Length=380, Percent_Identity=36.5789473684211, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI45550452, Length=401, Percent_Identity=36.6583541147132, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24653819, Length=356, Percent_Identity=30.8988764044944, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24653817, Length=332, Percent_Identity=29.2168674698795, Blast_Score=156, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55074; Mature: 54943

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIYVPRDSSALALGADALAAAIAAEAERRGVAVELVRNGSRGLLWLEPLVEVGTAAG
CCCEEEECCCCCCEEECHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCCCCC
RVGYANLSAADVLALFDANWLEGGAHPSGVGLVDALPYLARQQRLTFARIGLTDPLSIDD
CCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHH
YLQYEGLAGLKNVLALDGDAVCEALIESGLRGRGGAAFPAGIKWRTVRQASATQKYIVCN
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEE
ADEGDSGTFSDRLIMECDPYCLIEGMIIAGVATGATVGYIYVRSEYPHAIATLEAAIVRA
CCCCCCCCCCCEEEEECCCHHHCCCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHH
REAGWLGEHVLGSAHAFELHVAKGAGSYVCGEETALLESLEGKRGVVRAKPPLPALAGLY
HHCCCCHHHHHCCCEEEEEEEECCCCCEECCCHHHHHHHCCCCCCEEECCCCCHHHHCCC
GQPTVINNVITLATAPVIFARGAAFYRDYGMGRSRGTLPFQLAGNIRHGGLVELSFGVTL
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEECCHHH
RELLFDFGGGTASGRPARAAQVGGPLGTYLPDHQWDVPLDYEAYTAIGAVVGHGGIVLHD
HHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEC
DTSNLAELAEYSMKFCAIESCGKCTPCRIGSTRGVETIARIRDGDTSERQVTLLRDLCDT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
MLAGSLCAMGGMTPYPVLSALDHFPEDFGLAAGKDAASGPVKAAA
HHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTRIYVPRDSSALALGADALAAAIAAEAERRGVAVELVRNGSRGLLWLEPLVEVGTAAG
CCEEEECCCCCCEEECHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEHHHHHHHCCCCC
RVGYANLSAADVLALFDANWLEGGAHPSGVGLVDALPYLARQQRLTFARIGLTDPLSIDD
CCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHH
YLQYEGLAGLKNVLALDGDAVCEALIESGLRGRGGAAFPAGIKWRTVRQASATQKYIVCN
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHCCCCCEEEEEE
ADEGDSGTFSDRLIMECDPYCLIEGMIIAGVATGATVGYIYVRSEYPHAIATLEAAIVRA
CCCCCCCCCCCEEEEECCCHHHCCCCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHH
REAGWLGEHVLGSAHAFELHVAKGAGSYVCGEETALLESLEGKRGVVRAKPPLPALAGLY
HHCCCCHHHHHCCCEEEEEEEECCCCCEECCCHHHHHHHCCCCCCEEECCCCCHHHHCCC
GQPTVINNVITLATAPVIFARGAAFYRDYGMGRSRGTLPFQLAGNIRHGGLVELSFGVTL
CCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEECCHHH
RELLFDFGGGTASGRPARAAQVGGPLGTYLPDHQWDVPLDYEAYTAIGAVVGHGGIVLHD
HHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEC
DTSNLAELAEYSMKFCAIESCGKCTPCRIGSTRGVETIARIRDGDTSERQVTLLRDLCDT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
MLAGSLCAMGGMTPYPVLSALDHFPEDFGLAAGKDAASGPVKAAA
HHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]