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The map label for this gene is guaD [H]

Identifier: 78065601

GI number: 78065601

Start: 1059985

End: 1061301

Strand: Reverse

Name: guaD [H]

Synonym: Bcep18194_A4129

Alternate gene names: 78065601

Gene position: 1061301-1059985 (Counterclockwise)

Preceding gene: 78065602

Following gene: 78065600

Centisome position: 28.73

GC content: 68.64

Gene sequence:

>1317_bases
ATGACGCAAACCGCTTTTCGTTCCCAGCTGCTGACCTTCAACGGCGACCCGGCGCAATCGAGCCAGGCCGCGAACTACGA
GACCGACGGCCTCCTGATCGTCGACGACGGCAAGGTCGTCGCGGCCGGCCCGTACGCGCAGCTCGCCGCGACGCTCGCGC
GCGACACGATCGTCCACGACCTGCGCGACAAGCTGATCGTGCCCGGCTTCATCGACACGCACATCCACTATCCGCAGACG
GACATGATCGCGTCGCCGGCGCCGGGCCTGCTGCCGTGGCTGGACAAGTACACGTTCCCGACCGAGCGCCAGTTCGGCGA
TCCCGAGCATGCGCGCGAAGTCGCCGACTTCTTCGTCGACGAACTGCTCGCCTGCGGCACGACGAGCGCGCTCGTCTACT
GCACGGTGCACAAGCAGTCGGCCGATGCGCTGTTCGCGTCGAGCGACGCACGCGACCTGCGGATGATCGCGGGCAAGGTG
CTGATGGACCGCAACTGCCCCGAATTCCTGCGCGATACCGCGCAATCGGGTTACGACGACAGCGCCGAGCTGATCGACCG
CTGGCACGGCAAGGGCCGCCAGATGTACGCGCTCACGCCGCGCTTCGCGCCGACGTCGACCGAAGCGCAGCTCGAGGCGT
GCAGCGAGCTCGCGCGCCGCCATCCGGACGTGTTCGTGCAGAGCCACGTCGCGGAAAACGTCGACGAAGTGAAATGGGTG
GCCGAGCTGTTCCCCGGCCATCGCAGCTATCTCGACATCTACGACCGCTACGGTCTGCTGCGCCCGCGCGCGGTGTACGG
CCACTGCATCCACCTCGACGACGAGGACCGCCGCCGGATGGCCGAGACGCGCACGGTCGTCGCACACTGCCCGACCTCGA
ACTTCTTCCTCGGCAGCGGGCTGTTCGATTTCGACAAGGCCGGTGAATACGACGTGCCCGTCACGCTCGCGACCGACGTC
GGCGGCGGCACGTCGTTCTCGATGCTGCAGACGATGAACGAGGCGCACAAGGTCGCGCGGCTGTCGGGCCACCACCTGAC
CGCGACGCGGATGTTCTGGCTCGCGACGGCCGGCGCCGCGCAGGCACTCGACCTTACCGATACGGTCGGCACGCTCGCGC
CGCGCACCGAGGCCGACTTCGTCGTGCTCGATCCGCAGGCCACGCCGCTGCTCGCGCGCCGCACGAAGCGCGCGGATTCG
CTCGAGGAGCTGCTGTTCGCATTCGCACTGCTCGGCGACGACCGCGCGGTGTACCGCACCTATGCGGCCGGCAAACTCGT
TCACGAGCGCGGCGCGGCACGCCGCGCGGCCGCGTAA

Upstream 100 bases:

>100_bases
CACGCAGTGTGCCGCACCCGCTCGCCAGGCGCCGCCTTGCCCTCGTGCGGCGTCGCTCGTTTTCTTCTGTTCGCCTTACC
TTGATGCAGGACCATTCGTC

Downstream 100 bases:

>100_bases
CAGCGTTCCGGGCGCGTTTCCCGGCAGGCGCGGGCATCCGCCACCGTGCCTGCCGGGCCTCCCGTCCCGCCGGAGATTGC
CGTCCGCCGATCCCACCCCG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTQTAFRSQLLTFNGDPAQSSQAANYETDGLLIVDDGKVVAAGPYAQLAATLARDTIVHDLRDKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFASSDARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACSELARRHPDVFVQSHVAENVDEVKWV
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYDVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLTDTVGTLAPRTEADFVVLDPQATPLLARRTKRADS
LEELLFAFALLGDDRAVYRTYAAGKLVHERGAARRAAA

Sequences:

>Translated_438_residues
MTQTAFRSQLLTFNGDPAQSSQAANYETDGLLIVDDGKVVAAGPYAQLAATLARDTIVHDLRDKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFASSDARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACSELARRHPDVFVQSHVAENVDEVKWV
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYDVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLTDTVGTLAPRTEADFVVLDPQATPLLARRTKRADS
LEELLFAFALLGDDRAVYRTYAAGKLVHERGAARRAAA
>Mature_437_residues
TQTAFRSQLLTFNGDPAQSSQAANYETDGLLIVDDGKVVAAGPYAQLAATLARDTIVHDLRDKLIVPGFIDTHIHYPQTD
MIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFASSDARDLRMIAGKVL
MDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACSELARRHPDVFVQSHVAENVDEVKWVA
ELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYDVPVTLATDVG
GGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLTDTVGTLAPRTEADFVVLDPQATPLLARRTKRADSL
EELLFAFALLGDDRAVYRTYAAGKLVHERGAARRAAA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=418, Percent_Identity=32.2966507177034, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1789249, Length=416, Percent_Identity=49.7596153846154, Blast_Score=450, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319963, Length=402, Percent_Identity=31.0945273631841, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24643849, Length=452, Percent_Identity=31.6371681415929, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48400; Mature: 48269

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRSQLLTFNGDPAQSSQAANYETDGLLIVDDGKVVAAGPYAQLAATLARDTIVHD
CCCHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHH
LRDKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVD
HHHCEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFASSDARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACSELARRHPDVFVQSHVAENVDEVKWV
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHHEEEEECCCCCEEECCC
LFDFDKAGEYDVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHEECCCC
QALDLTDTVGTLAPRTEADFVVLDPQATPLLARRTKRADSLEELLFAFALLGDDRAVYRT
CEEECHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGKLVHERGAARRAAA
HHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TQTAFRSQLLTFNGDPAQSSQAANYETDGLLIVDDGKVVAAGPYAQLAATLARDTIVHD
CCHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHHHH
LRDKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVD
HHHCEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFASSDARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACSELARRHPDVFVQSHVAENVDEVKWV
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHHEEEEECCCCCEEECCC
LFDFDKAGEYDVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHEECCCC
QALDLTDTVGTLAPRTEADFVVLDPQATPLLARRTKRADSLEELLFAFALLGDDRAVYRT
CEEECHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGKLVHERGAARRAAA
HHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]