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The map label for this gene is zwf [H]

Identifier: 78065542

GI number: 78065542

Start: 996257

End: 997726

Strand: Reverse

Name: zwf [H]

Synonym: Bcep18194_A4070

Alternate gene names: 78065542

Gene position: 997726-996257 (Counterclockwise)

Preceding gene: 78065547

Following gene: 78065541

Centisome position: 27.01

GC content: 66.33

Gene sequence:

>1470_bases
ATGCATACCGATTCCAGCTTTACCTTCGTACTTTTCGGCGGCACCGGCGATCTGTCGATGCGCAAGATCCTGCCCGCGCT
GTTCGAGGCGCACCGTGCGAACATGCTGGCGGAGAGCGGCCGGATCGTTGCCGTGGCGCGTCATGAATCGGATCGGGCGT
CCTATCTGGAATGGGTCGACACCCACGTGAAGCCGCACGCGGCCAAGGCCGCCGGCAAGGCGTTCGACGAAGCTGCGTGG
AAATCCTTCCTCGATCGCATCGAGTACGTGCACCTCGATCTCGGCCGCGCGGAAGACTACGGCGTGCTGCGCGACGCGGT
GGCCTCGCTGCCCGGCATCCGCGTGTTCTATCTGGCGACGGGCCCGTCGCTGTTCGTGCCGATCTGCAAGGCGCTCGCGT
CGGTCGGCCTGAACGAAGGCTCGCGCATCGTGCTCGAGAAGCCGCTCGGCTACGACCTGAAGTCGTCGAACGCGATCAAC
GACGCGGTCGGCGAGATCTTCGCGGAAGGCCAGATCTACCGGATCGACCACTATCTCGGCAAGGAACCCGTGCAGAACCT
GCTCGCGCTGCGCTTCGGCAATGCGCTGTTCGAGCCGCTGTGGCGCCGCGAATGGGTCGAGAGCATCCAGATCACGATCG
CCGAGGAGCTCGGCGTCGAGGCGCGCGGCGATTTCTATGACAATACGGGCGCGCTGCGCGACATGGTGCAGAACCACCTG
CTGCAGCTGCTGTCGATCGTCGCAATGGAGCCGCCGCATTCGATGGATTCGGATTCGGTGCGCGACGAGAAGCTGCGCGT
GCTGCGCGCGCTGAAACCGGTCGATCCGCGCGACATCGGCAAGGTTGCCGTGCGCGGCCAGTATCATGCGGGCGTGATCA
AGGGCGCGCAGGTGCCGGCGTACGCAACCGAGCCGGGCGTGAAGCCCGACAGCCAGACCGAAACCTTCGTCGCGCTGAAG
GTCGAGATCGAGAACTGGCGCTGGGCCGGCGTGCCGTTCTTCCTGCGCACCGGCAAGCGGCTCGCCGATCGCGTCGCGGA
GATCGTCGTCAATTTCCGCCCGGTGCCGCATTCGGCGCTCGGGCCCACCGCGCTGCGTCCCGGCTCGAACCGCCTCGTGA
TCCGGCTGCAGCCGAACGAGACGATCCGCCTGTACTGCCTCGCGAAGCAGCCCGGCGAAGGGATGAACCTCGCGAGCGTG
CACCTCGACCTCGCGTTCGACCAGTTCTTCAAGGAAGGGCAGATGGAGGCGTACCAGCGCCTGCTGCTCGACGTGATCAA
CGGCCGTCTCGCCCTCTTCGTGCGCCGCGACGAACAAGAAGCCGCATGGCGCTGGGTCGAGCCTATCCTGAACGAATGGG
CACGCTCGCTGAAGCCGCCGAAGCCGTACGCGGCGGGCACGTGGGGGCCGGCCGCGGCGAGCGCGATGCTCGCGCAGCAC
GACACCTGCTGGCTCGAAGAAGAGAACTGA

Upstream 100 bases:

>100_bases
TACCCCTTGCGGCGGATTGTAGTTAAACTACAATTCAGTGTCAAAAATATTTTTATCGCACTACGGATCGCTTCCCAGCA
CCCCAACCCGGCGGAGACAC

Downstream 100 bases:

>100_bases
TGCAAACCGTTGCCGCGCACGCCACCGTACGCGGCAACGTGCCCCGCGATTCGTACGATTTGAACAGACAAAGCAGTCCG
GAGGAGATGTGATCGAGATT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAESGRIVAVARHESDRASYLEWVDTHVKPHAAKAAGKAFDEAAW
KSFLDRIEYVHLDLGRAEDYGVLRDAVASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAAASAMLAQH
DTCWLEEEN

Sequences:

>Translated_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAESGRIVAVARHESDRASYLEWVDTHVKPHAAKAAGKAFDEAAW
KSFLDRIEYVHLDLGRAEDYGVLRDAVASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAAASAMLAQH
DTCWLEEEN
>Mature_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAESGRIVAVARHESDRASYLEWVDTHVKPHAAKAAGKAFDEAAW
KSFLDRIEYVHLDLGRAEDYGVLRDAVASLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAIN
DAVGEIFAEGQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPAYATEPGVKPDSQTETFVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAAASAMLAQH
DTCWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=37.1951219512195, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=37.1951219512195, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI52145310, Length=362, Percent_Identity=33.1491712707182, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788158, Length=492, Percent_Identity=44.1056910569106, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17538218, Length=490, Percent_Identity=35.3061224489796, Blast_Score=314, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=35.5509355509356, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=35.8606557377049, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=35.8606557377049, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI221513548, Length=489, Percent_Identity=30.6748466257669, Blast_Score=212, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54610; Mature: 54610

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAESGRIVAVARHESDRASYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
THVKPHAAKAAGKAFDEAAWKSFLDRIEYVHLDLGRAEDYGVLRDAVASLPGIRVFYLAT
HCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAINDAVGEIFAEGQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEHHHHC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKPDSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
DTCWLEEEN
CCCEEECCC
>Mature Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAESGRIVAVARHESDRASYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
THVKPHAAKAAGKAFDEAAWKSFLDRIEYVHLDLGRAEDYGVLRDAVASLPGIRVFYLAT
HCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLKSSNAINDAVGEIFAEGQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEHHHHC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGAQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEECCCCCC
YATEPGVKPDSQTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGSNRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
DTCWLEEEN
CCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]