Click here to switch to the map view.

The map label for this gene is livM [H]

Identifier: 78065484

GI number: 78065484

Start: 936903

End: 938090

Strand: Reverse

Name: livM [H]

Synonym: Bcep18194_A4012

Alternate gene names: 78065484

Gene position: 938090-936903 (Counterclockwise)

Preceding gene: 78065485

Following gene: 78065483

Centisome position: 25.39

GC content: 66.5

Gene sequence:

>1188_bases
GTGACTTCATTCACCCACTCGTTGTCCAATCCGGCCGCCGATGCGCCGAAGCCGGCTGCCGCCGCACGCACGGAAGAGCG
CTTCGCGCTCGGCCTGCCGCCCCGCCCCGCGCTGCTGTCGCGACGCGCGTGGCTCGCGCTGATCGCGCTGTGCGTCGCGA
TCGGCATCGGCGTGCCGCTCGCCGCGCTCGTCGCGCCCGAGTCGAGCGCGTTCCATCTGTCCGCGTACGCGATGACGCTC
ACCGGCAAGCTGATGTGCTACGCGATCGCCGCACTCGCGCTCGATCTCGTGTGGGGCTACTGCGGGATCCTGAGCCTCGG
CCACGGGCTGTTCTTCGCGCTCGGCGGCTATGCGATCGGAATGTATCTGATGCGCGAAATCGGCCGCGACGGCAAGTACG
GCAGCGACCTACCCGATTTCATGGTGTTCCTCGACTGGCACCAGTTGCCGTGGTACTGGAGCGGCACGCAGCATCTCGCG
TGGGCGCTCGCACTCGTCGTGCTCGTGCCGGCCGTGCTCGCGTGGGTGTTCGGCTTCTTCACGTTCCGCTCGCGCGTGAA
GGGCGTGTACCTGTCGATCATCACGCAGGCCATGACGTTCGCCGCGATGCTGCTGTTCTATCGTAACGAGACGGGCTTCG
GCGGCAACAACGGCTTCACCGACTTCAAGCGCATCGCAGGCTTTGCGATCACGTCGCCCGGCACGCGCACGGTGCTGTTG
CTGATGACGTTCGCGACGCTCGTGCTCGCGTTCATCGCCGCGCGTGCGATCGTCACCAGCAAGCTCGGGCGTGTCGTCAC
CGCGGTGCGCGATGGCGAGACGCGGCTGATGTTCCTCGGTTACAGCCCGCTCGCATACAAGCTGTTCGTGTGGACCGTGT
CGGCCGTGCTGTGCGGCATCGCGGGCGCGTTGTACGTGCCGCAGGTCGGCATCATCAACCCCGGCGAGATGTCGCCCGGC
AACTCGATCGAGATGGCGATCTGGGTCGCGGTGGGCGGGCGCGGCACGCTGATCGGACCGATCGTCGGCGCGTTCGCGGT
GAACGGCGCGAAGAGCGTTTTTACCGCGTACTTCGCCGAATACTGGCTGTTCTTCCTCGGCCTGATCTTCGTGCTCGTGC
CGCTGCTGTTGCCGCGCGGGATCATGGGCCTCGTCGAAACCTTGATCGCGAAGGGGAAACGCGCATGA

Upstream 100 bases:

>100_bases
GTGCTCGCGAAGATCGCGGTGCTCGTGATGATCGTGCTGTTCATCCAGAAACGTCCGCAGGGCATGTTTGCCCCGAAGGG
CCGCAGTGCGGAGGCTTGAC

Downstream 100 bases:

>100_bases
ACGGAACGGCCCTGTACCAGTTCACGCCGCCGCCCGAAGACGAAGGGCTGGCCGTCAGCGGCACCGCATCGATGGGGCGC
GTGGTGCCGCCCGGCATCGA

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTSFTHSLSNPAADAPKPAAAARTEERFALGLPPRPALLSRRAWLALIALCVAIGIGVPLAALVAPESSAFHLSAYAMTL
TGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGKYGSDLPDFMVFLDWHQLPWYWSGTQHLA
WALALVVLVPAVLAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFAITSPGTRTVLL
LMTFATLVLAFIAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEMSPG
NSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGLVETLIAKGKRA

Sequences:

>Translated_395_residues
MTSFTHSLSNPAADAPKPAAAARTEERFALGLPPRPALLSRRAWLALIALCVAIGIGVPLAALVAPESSAFHLSAYAMTL
TGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGKYGSDLPDFMVFLDWHQLPWYWSGTQHLA
WALALVVLVPAVLAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFAITSPGTRTVLL
LMTFATLVLAFIAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEMSPG
NSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGLVETLIAKGKRA
>Mature_394_residues
TSFTHSLSNPAADAPKPAAAARTEERFALGLPPRPALLSRRAWLALIALCVAIGIGVPLAALVAPESSAFHLSAYAMTLT
GKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGKYGSDLPDFMVFLDWHQLPWYWSGTQHLAW
ALALVVLVPAVLAWVFGFFTFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFAITSPGTRTVLLL
MTFATLVLAFIAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQVGIINPGEMSPGN
SIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGLVETLIAKGKRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=339, Percent_Identity=25.0737463126844, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42504; Mature: 42373

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFTHSLSNPAADAPKPAAAARTEERFALGLPPRPALLSRRAWLALIALCVAIGIGVPL
CCCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHH
AALVAPESSAFHLSAYAMTLTGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIG
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYLMREIGRDGKYGSDLPDFMVFLDWHQLPWYWSGTQHLAWALALVVLVPAVLAWVFGFF
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHH
TFRSRVKGVYLSIITQAMTFAAMLLFYRNETGFGGNNGFTDFKRIAGFAITSPGTRTVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCEEECCCCHHHHHH
LMTFATLVLAFIAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCHHHHHHHHHHHHHHHHHH
AGALYVPQVGIINPGEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAE
HHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHH
YWLFFLGLIFVLVPLLLPRGIMGLVETLIAKGKRA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSFTHSLSNPAADAPKPAAAARTEERFALGLPPRPALLSRRAWLALIALCVAIGIGVPL
CCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHH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HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]