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The map label for this gene is algA [H]

Identifier: 78065453

GI number: 78065453

Start: 903302

End: 904729

Strand: Reverse

Name: algA [H]

Synonym: Bcep18194_A3979

Alternate gene names: 78065453

Gene position: 904729-903302 (Counterclockwise)

Preceding gene: 78065454

Following gene: 78065452

Centisome position: 24.49

GC content: 61.2

Gene sequence:

>1428_bases
ATGTCGACGCAGCCCCAAATAGTTCCCACCATCCTGTGTGGCGGCGCAGGCTCTCGCCTGTGGCCCGTTTCGCGCGAATC
CCATCCGAAGCCGTTCATCCGCCTCGAAGATGGCGAGAGCCTGCTGCAAAAGGCATTCAAGCGCGGCACCCAGCTTCCGG
GCGTCACCGAAGTCGTGACCGTCACGAACCGCGAGTTGTACTTCAAGACAAGCGACGAATTCAGCACCGTCAATACCGGG
CATCTGTCGACGTCGTTCATCCTCGAGCCGTTCGGCCGCAATACGGCCGTCGCGATCGCTGCCGCCGCGCTGCGTGTTGC
CGCAACGCTCGGCGAAAATGCAATCCTGCTGGTGCTTCCCGCGGACCACCTCGTGACAGACGATGCCGCCTTCGCGACCG
CCGTCCAGGAAGCTGCCGCCTTGGCGCTCAAGGGTGCGCTGGTCACCTTCGGCATCACGCCGACGTTTGCGGAAACCGCA
TACGGATACATCGAGGCAGACGGCACGCGGGTCAAGCGATTCGTGGAAAAGCCGACGGTGGACGTGGCCAGGCAATACGT
CGAGTCGGGATCGTTCCTGTGGAACTCCGGCATGTTCTGCTTTACCGCCGCATTCCTGCTGGCGGAAATGGCAAAACATT
GCCCGGACGTGCTCGAAGCCACGCGTGCATGCATCGCGCAGTCTCGTCAGTCGGAAGGCGGCGGCGTGTCATTGGTCGAA
CTGAACGGTGACCTGCTGAATCGCTCGCCCGATATTTCGATCGACTACGCGCTGATGGAGCGCTCCGACAAGGTTGCGGT
CGTGCGCTGCGATATCGGCTGGAGCGATATCGGTTCGTGGAATGCGCTCGGCGACCTGTTGAAGCCGGACGACCACGGCA
ATCGTGTGGACGGCGAAGCGCTGCTCCACGATGTCAGCAATTGCTACATCCGTAGCGACAACCGGCTGGTCGGCGCCGTA
GGCGTCAAGGACCTCCTGGTCGTCGACACCCCCGACGCACTCCTCATTGCCGATCGCAATCGCGCGCAAGACGTTCGGCA
CGTCTACGCGGCCCTCAAGTCGCAAGGCCACGAAACCTTCCGGGTACATCGAACGGTAGGCCGTCCGTGGGGCATGTATA
CGGTTCTCGAAGAAAGCACACGCTTCAAGATCAAGCGAATCGAGGTCAAACCGGGCGCAAGCCTCAGCCTGCAGTTGCAT
CATCATCGCAGCGAACACTGGATCGTGGTGAGCGGCATGGCCCTCGTCGTCAACAACGATGAGGAGTTTTACCTGCGCAC
CAATGAATCGACCTATATCCCGGCCGGACACAAGCACCGTCTGACCAATCCGGGCGTCGTCGACCTCGTGATGATCGAAG
TCCAGAGCGGCGACTATCTCGGCGAAGACGACATCGTCCGCTTCGACGACAACTACGGTCGAAGCTAG

Upstream 100 bases:

>100_bases
GCCTGCCGCCTTGCATCAGTGGCAGTTGCCGTGCACGCGGATAGATCGCCGACCGATCGGATCATGACGCGATAGAGCAA
TCACCGGAGATATTCTGCAC

Downstream 100 bases:

>100_bases
CCTTCTGCCATCGCGCAAAGGCGGTTGCAGTCGTCGTCCTTTCCGGCGCGCGACGACAGCAACCGTCTGATTAACCGCTC
CCTCACATCATGACCAATGC

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSTQPQIVPTILCGGAGSRLWPVSRESHPKPFIRLEDGESLLQKAFKRGTQLPGVTEVVTVTNRELYFKTSDEFSTVNTG
HLSTSFILEPFGRNTAVAIAAAALRVAATLGENAILLVLPADHLVTDDAAFATAVQEAAALALKGALVTFGITPTFAETA
YGYIEADGTRVKRFVEKPTVDVARQYVESGSFLWNSGMFCFTAAFLLAEMAKHCPDVLEATRACIAQSRQSEGGGVSLVE
LNGDLLNRSPDISIDYALMERSDKVAVVRCDIGWSDIGSWNALGDLLKPDDHGNRVDGEALLHDVSNCYIRSDNRLVGAV
GVKDLLVVDTPDALLIADRNRAQDVRHVYAALKSQGHETFRVHRTVGRPWGMYTVLEESTRFKIKRIEVKPGASLSLQLH
HHRSEHWIVVSGMALVVNNDEEFYLRTNESTYIPAGHKHRLTNPGVVDLVMIEVQSGDYLGEDDIVRFDDNYGRS

Sequences:

>Translated_475_residues
MSTQPQIVPTILCGGAGSRLWPVSRESHPKPFIRLEDGESLLQKAFKRGTQLPGVTEVVTVTNRELYFKTSDEFSTVNTG
HLSTSFILEPFGRNTAVAIAAAALRVAATLGENAILLVLPADHLVTDDAAFATAVQEAAALALKGALVTFGITPTFAETA
YGYIEADGTRVKRFVEKPTVDVARQYVESGSFLWNSGMFCFTAAFLLAEMAKHCPDVLEATRACIAQSRQSEGGGVSLVE
LNGDLLNRSPDISIDYALMERSDKVAVVRCDIGWSDIGSWNALGDLLKPDDHGNRVDGEALLHDVSNCYIRSDNRLVGAV
GVKDLLVVDTPDALLIADRNRAQDVRHVYAALKSQGHETFRVHRTVGRPWGMYTVLEESTRFKIKRIEVKPGASLSLQLH
HHRSEHWIVVSGMALVVNNDEEFYLRTNESTYIPAGHKHRLTNPGVVDLVMIEVQSGDYLGEDDIVRFDDNYGRS
>Mature_474_residues
STQPQIVPTILCGGAGSRLWPVSRESHPKPFIRLEDGESLLQKAFKRGTQLPGVTEVVTVTNRELYFKTSDEFSTVNTGH
LSTSFILEPFGRNTAVAIAAAALRVAATLGENAILLVLPADHLVTDDAAFATAVQEAAALALKGALVTFGITPTFAETAY
GYIEADGTRVKRFVEKPTVDVARQYVESGSFLWNSGMFCFTAAFLLAEMAKHCPDVLEATRACIAQSRQSEGGGVSLVEL
NGDLLNRSPDISIDYALMERSDKVAVVRCDIGWSDIGSWNALGDLLKPDDHGNRVDGEALLHDVSNCYIRSDNRLVGAVG
VKDLLVVDTPDALLIADRNRAQDVRHVYAALKSQGHETFRVHRTVGRPWGMYTVLEESTRFKIKRIEVKPGASLSLQLHH
HRSEHWIVVSGMALVVNNDEEFYLRTNESTYIPAGHKHRLTNPGVVDLVMIEVQSGDYLGEDDIVRFDDNYGRS

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=482, Percent_Identity=43.5684647302905, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 52123; Mature: 51991

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQPQIVPTILCGGAGSRLWPVSRESHPKPFIRLEDGESLLQKAFKRGTQLPGVTEVVT
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCEEEEE
VTNRELYFKTSDEFSTVNTGHLSTSFILEPFGRNTAVAIAAAALRVAATLGENAILLVLP
EECCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
ADHLVTDDAAFATAVQEAAALALKGALVTFGITPTFAETAYGYIEADGTRVKRFVEKPTV
CCCEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEEECCCHHHHHHHHCCCH
DVARQYVESGSFLWNSGMFCFTAAFLLAEMAKHCPDVLEATRACIAQSRQSEGGGVSLVE
HHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEE
LNGDLLNRSPDISIDYALMERSDKVAVVRCDIGWSDIGSWNALGDLLKPDDHGNRVDGEA
ECCHHHCCCCCCEEEEHEECCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHH
LLHDVSNCYIRSDNRLVGAVGVKDLLVVDTPDALLIADRNRAQDVRHVYAALKSQGHETF
HHHHCCCCEEECCCEEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCEE
RVHRTVGRPWGMYTVLEESTRFKIKRIEVKPGASLSLQLHHHRSEHWIVVSGMALVVNND
EEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEEEEEEEECC
EEFYLRTNESTYIPAGHKHRLTNPGVVDLVMIEVQSGDYLGEDDIVRFDDNYGRS
CEEEEEECCCEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
STQPQIVPTILCGGAGSRLWPVSRESHPKPFIRLEDGESLLQKAFKRGTQLPGVTEVVT
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCEEEEE
VTNRELYFKTSDEFSTVNTGHLSTSFILEPFGRNTAVAIAAAALRVAATLGENAILLVLP
EECCEEEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
ADHLVTDDAAFATAVQEAAALALKGALVTFGITPTFAETAYGYIEADGTRVKRFVEKPTV
CCCEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEEECCCHHHHHHHHCCCH
DVARQYVESGSFLWNSGMFCFTAAFLLAEMAKHCPDVLEATRACIAQSRQSEGGGVSLVE
HHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEE
LNGDLLNRSPDISIDYALMERSDKVAVVRCDIGWSDIGSWNALGDLLKPDDHGNRVDGEA
ECCHHHCCCCCCEEEEHEECCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHH
LLHDVSNCYIRSDNRLVGAVGVKDLLVVDTPDALLIADRNRAQDVRHVYAALKSQGHETF
HHHHCCCCEEECCCEEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCEE
RVHRTVGRPWGMYTVLEESTRFKIKRIEVKPGASLSLQLHHHRSEHWIVVSGMALVVNND
EEEECCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEEEEEEEECC
EEFYLRTNESTYIPAGHKHRLTNPGVVDLVMIEVQSGDYLGEDDIVRFDDNYGRS
CEEEEEECCCEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]