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The map label for this gene is groEL

Identifier: 78065429

GI number: 78065429

Start: 877782

End: 879422

Strand: Direct

Name: groEL

Synonym: Bcep18194_A3955

Alternate gene names: 78065429

Gene position: 877782-879422 (Clockwise)

Preceding gene: 78065428

Following gene: 78065434

Centisome position: 23.76

GC content: 61.91

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTATTCGGCGATTCCGCCCGTTCGAAGATGGTCGAAGGCGTGAACATTCTCGCCAACGCAGT
CAAGGTCACGCTGGGTCCGAAGGGCCGCAACGTGGTGCTCGAGCGCAGCTTCGGCGGCCCGACGGTCACCAAGGACGGTG
TGTCGGTCGCGAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCGCAAATGGTCAAGGAAGTTGCTTCCAAG
ACCAGCGACAACGCAGGCGACGGCACGACGACGGCAACCGTCCTCGCGCAATCGATCGTTCGCGAAGGCATGAAGTACGT
CGCATCGGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCAGTCGCAGCGGCTGTCGAAGAGCTGAAGAAGA
TCAGCAAGCCGTGCACGACGAACAAGGAAATCGCACAGGTCGGCTCGATCTCGGCGAACAGCGACACGTCGATCGGCGAT
CGCATCGCTGAAGCGATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAAGACGGCAAGTCGCTGGCTGACGAACT
CGACGTCGTCGAAGGCATGCAATTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGAAAAGCAAGTCGCCG
TGCTCGACAACCCGTTCGTGCTGCTGCACGACAAGAAGGTGTCGAACATCCGTGATCTGCTGCCGGTACTCGAGCAAGTC
GCGAAGGCTGGCCGTCCGCTGCTGATCATCGCTGAAGACATCGAAGGCGAAGCGCTCGCAACGCTGGTCGTCAACAACAT
CCGCGGCATCCTGAAGACCGTTGCGGTCAAGGCACCGGGCTTCGGCGACCGTCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACCGGCGGCCAGGTGATCGCGGAAGAAACCGGCCTGACGCTCGAGAAGGCAACGCTGGCAGAACTGGGCCAGGCG
AAGCGCATCGAAGTGGGCAAGGAAAACACGACGATCATCGACGGCGCAGGCGAAGCCGTGAACATCGAAGCACGCGTGAA
GCAAGTGCGCGCGCAAATCGAAGAAGCGACGTCGGACTACGACCGTGAAAAGCTGCAAGAGCGCGTGGCCAAGCTGGCCG
GCGGTGTTGCAGTGATCAAGGTCGGTGCAGCGACCGAAGTCGAAATGAAGGAAAAGAAGGCACGTGTCGAAGACGCACTG
CACGCAACGCGCGCAGCTGTGGAAGAAGGCATCGTGGCAGGTGGCGGCGTTGCGCTGATCCGCGCTCGCACCGCGATCGC
AGCCCTGACCGGCGCTAACGCCGATCAAAACGCCGGCATCAAGATCGTGCTGCGCGCAATGGAAGAGCCGCTGCGCCAGA
TCGTCACGAACGGCGGCGAAGAAGCCAGCGTCGTGGTGGCGGCAGTTGCTGCAGGTACGGGCAACTACGGCTACAACGCA
GCGACGGGCGAGTACGTCGACATGGTCGAAGCCGGTGTTGTCGACCCGACCAAGGTCACGCGTACCGCACTGCAGAACGC
AGCTTCGGTTGCAGGCCTGCTGCTGACGACGGACGCAGCGGTTGCTGAACTGCCGAAGGAAGACGCACCGATGCCGGGCG
GCATGCCGGGCGGCATGGGCGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
GAACTGCTGGTCATGCGCGAAGAAGACATCATGGCCGTGGTCAACGCGAAGTAAGCGTCCACCGACGGTACATATTCCCA
AGAATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TCGACTTCGGTCGATGGTGTCCGGAGCGCGCAGCGATGCGCGTTCCAGCCAAAAGAAAAGACCCGCAGCGATGCGGGTCT
TTTTTTATGGATTTGCCGGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDTSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDIEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARTAIAALTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDTSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDIEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARTAIAALTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDTSIGDR
IAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPEKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDIEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAK
RIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRARTAIAALTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNAA
TGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.4090909090909, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.4090909090909, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI24307939, Length=363, Percent_Identity=24.2424242424242, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI5453607, Length=552, Percent_Identity=22.463768115942, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.8034026465028, Blast_Score=798, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.5519848771267, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=51.3761467889908, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25144674, Length=548, Percent_Identity=22.0802919708029, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=35.1145038167939, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=51.3307984790874, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322524, Length=389, Percent_Identity=24.1645244215938, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=577, Percent_Identity=22.5303292894281, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=561, Percent_Identity=23.3511586452763, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.8026565464896, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.8026565464896, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.4743833017078, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=43.8181818181818, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=36.6541353383459, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=36.6541353383459, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17647245, Length=503, Percent_Identity=23.4592445328032, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24652903, Length=448, Percent_Identity=23.8839285714286, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57065; Mature: 56934

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDTSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPEKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDIEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARTAIAALTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARSKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGSISANSDTSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPEKQVAVLDNPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDIEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQVRAQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARTAIAALTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA