Click here to switch to the map view.

The map label for this gene is kbl [C]

Identifier: 78065349

GI number: 78065349

Start: 793249

End: 794577

Strand: Direct

Name: kbl [C]

Synonym: Bcep18194_A3875

Alternate gene names: 78065349

Gene position: 793249-794577 (Clockwise)

Preceding gene: 78065348

Following gene: 78065350

Centisome position: 21.47

GC content: 68.7

Gene sequence:

>1329_bases
ATGGCACTGGGAGAGCATCTTCGCCAGCAACTGGCGGCGAAAGCGCTGAAACGGCAACTGGAGCGCGCAACTGATGCTGC
CGCGGCACCGGGCGTGCCGGGCACGCTGGCCGCGCAGACCGCATCGGCGCGCAGCCGCTTCGAATCGATGCCGCAGTATC
AGCAGGTCCGGATCATGCGCGAGATGGGCGAGAAGCTGCGGGTCGACTCGCCGTTTTTCCGTGTGCACGACGGCGTGGCC
GGTGCGACGACGCAGATCGGCGGCCGCGAGTACCTGAACTTCGCGAACTACAACTACCTCGGCCTGGCCGGCGATCCGGC
CGTGTCGTCACGCGCGAAAGCCGCGATCGACCGCTACGGCACGTCGGCTTCCGCGAGCCGGATGGTCGCGGGCGAGCGCC
CGGTGCAGCGCGACCTCGAGCGCGCGCTGGCCGCGTTCTACGAGACCGACGACTGTGTCGCGTTCGTGAGCGGCCATGCG
ACGAACGTGACCGTGATCGGCGCGCTGTTCGGCCCCGGGGATCTGGTCGTCCACGATTCGCTCGCGCACAACAGCATCGT
GCAGGGTGCGCAACTGAGCGGCGCGAAGCGGCTGAGCTTCGCGCACAACGACTGGCAGGCGCTCGACGAACTGCTGTCGC
GCGTGCGCCGCGAATACCGGCACGTGCTGATCGCGATCGAAGGGCTGTACAGCATGGACGGCGATTTCCCCGACCTGCAG
CGCTTCGTCGACGTGAAGACGCGCCACGGTGCCTTCCTGCTGGTCGACGAGGCGCATTCGCTCGGCGTGCTCGGCGCGAC
CGGCAAGGGTATCCGCGAGCACTGCGGTGTCGCGCCCGACCAGGTCGACATGTGGATGGGCACGATGAGCAAGACGCTGG
CCGGTTGTGGCGGTTTCATCGCCGGCTGTCAGCCGCTGGTCGACATGCTGCGCCATCTGGCGCCGGGCTTCCTGTACAGC
GTCGGGCTCGCGCCGACGCTCGCCGAAGCATCGCTGGCTGCGCTCGAGCGCCTGCAGGCCGAGCCGCAGCGCGTTGCGCA
ACTGCAGGCGCGCGGGCGGCAGTTCCTGACCGAGGCGCGTGCCGCGGGGCTGAATACGGGCACGAGCGCCGGGTTCGCGG
TCGTGCCGGTGATCACGGGGAGCTCGCTGAAGGCCGCGCAATGGGCCAATGCGATGTTCGACGAAGGGATCAACGTGCAG
CCGATCTTCTATCCGGCCGTCGAGGAAAAGGCGGCGCGCCTGCGCTTCTTCATCTGCTCGACGCACGAGCCGGAGCAGAT
CAGCCGGACGGTCGCCGTGTTGTCGCGTCTCGCGGGGCGCAGCGCATGA

Upstream 100 bases:

>100_bases
GATGCGTGGCAGTGGGCCGAGTTTCCCGACGCGTGACACCACGCTTTTTCATGACGCGCGGCGTAACATAGCGTCTTTTC
GAGATACAGCGAAGGAAGCA

Downstream 100 bases:

>100_bases
CGCTGGCCGGCGCGTTCGCGCAAGCGGTTCCGCGCGCCGGTGAGCGCGTGCGGTTTCGCTCGGCCGATGCGGGCGACGCG
GCAGCGTGTGCACCGCTTGT

Product: glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVA
GATTQIGGREYLNFANYNYLGLAGDPAVSSRAKAAIDRYGTSASASRMVAGERPVQRDLERALAAFYETDDCVAFVSGHA
TNVTVIGALFGPGDLVVHDSLAHNSIVQGAQLSGAKRLSFAHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHCGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYS
VGLAPTLAEASLAALERLQAEPQRVAQLQARGRQFLTEARAAGLNTGTSAGFAVVPVITGSSLKAAQWANAMFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQISRTVAVLSRLAGRSA

Sequences:

>Translated_442_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVA
GATTQIGGREYLNFANYNYLGLAGDPAVSSRAKAAIDRYGTSASASRMVAGERPVQRDLERALAAFYETDDCVAFVSGHA
TNVTVIGALFGPGDLVVHDSLAHNSIVQGAQLSGAKRLSFAHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHCGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYS
VGLAPTLAEASLAALERLQAEPQRVAQLQARGRQFLTEARAAGLNTGTSAGFAVVPVITGSSLKAAQWANAMFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQISRTVAVLSRLAGRSA
>Mature_441_residues
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLAAQTASARSRFESMPQYQQVRIMREMGEKLRVDSPFFRVHDGVAG
ATTQIGGREYLNFANYNYLGLAGDPAVSSRAKAAIDRYGTSASASRMVAGERPVQRDLERALAAFYETDDCVAFVSGHAT
NVTVIGALFGPGDLVVHDSLAHNSIVQGAQLSGAKRLSFAHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQR
FVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHCGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYSV
GLAPTLAEASLAALERLQAEPQRVAQLQARGRQFLTEARAAGLNTGTSAGFAVVPVITGSSLKAAQWANAMFDEGINVQP
IFYPAVEEKAARLRFFICSTHEPEQISRTVAVLSRLAGRSA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=33.7912087912088, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI7657118, Length=362, Percent_Identity=34.2541436464088, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284448556, Length=341, Percent_Identity=34.3108504398827, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4758668, Length=349, Percent_Identity=32.378223495702, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=28.735632183908, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=28.735632183908, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=28.735632183908, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI5454084, Length=296, Percent_Identity=32.4324324324324, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4502025, Length=351, Percent_Identity=29.3447293447293, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI40316939, Length=351, Percent_Identity=29.3447293447293, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1790046, Length=352, Percent_Identity=36.3636363636364, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=29.8591549295775, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32566772, Length=353, Percent_Identity=33.1444759206799, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17560914, Length=463, Percent_Identity=27.8617710583153, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=30.1369863013699, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=29.2929292929293, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=366, Percent_Identity=30.327868852459, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=32.2033898305085, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=408, Percent_Identity=28.6764705882353, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320438, Length=349, Percent_Identity=29.7994269340974, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=220, Percent_Identity=30, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=31.3888888888889, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=28.7671232876712, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=29.2263610315186, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653280, Length=290, Percent_Identity=30.3448275862069, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653276, Length=290, Percent_Identity=30.3448275862069, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24653278, Length=290, Percent_Identity=30.3448275862069, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47551; Mature: 47419

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLAAQTASARSRFESMPQYQQVRIMR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVDSPFFRVHDGVAGATTQIGGREYLNFANYNYLGLAGDPAVSSRAKAAIDRYG
HHHHHHCCCCCHHEECCCCCCCHHCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRDLERALAAFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHDS
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCEEEECC
LAHNSIVQGAQLSGAKRLSFAHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
HHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHCGVAPDQVDMWMGTMSKTLAGCGGFI
HHHHHHCCCCEEEEEECCCCCCEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLVDMLRHLAPGFLYSVGLAPTLAEASLAALERLQAEPQRVAQLQARGRQFLTEAR
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAGLNTGTSAGFAVVPVITGSSLKAAQWANAMFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQISRTVAVLSRLAGRSA
CCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLAAQTASARSRFESMPQYQQVRIMR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVDSPFFRVHDGVAGATTQIGGREYLNFANYNYLGLAGDPAVSSRAKAAIDRYG
HHHHHHCCCCCHHEECCCCCCCHHCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRDLERALAAFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHDS
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCEEEECC
LAHNSIVQGAQLSGAKRLSFAHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
HHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHCGVAPDQVDMWMGTMSKTLAGCGGFI
HHHHHHCCCCEEEEEECCCCCCEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLVDMLRHLAPGFLYSVGLAPTLAEASLAALERLQAEPQRVAQLQARGRQFLTEAR
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAGLNTGTSAGFAVVPVITGSSLKAAQWANAMFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQISRTVAVLSRLAGRSA
CCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA