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The map label for this gene is lpxC [H]

Identifier: 78065348

GI number: 78065348

Start: 792267

End: 793184

Strand: Direct

Name: lpxC [H]

Synonym: Bcep18194_A3874

Alternate gene names: 78065348

Gene position: 792267-793184 (Clockwise)

Preceding gene: 78065347

Following gene: 78065349

Centisome position: 21.45

GC content: 71.68

Gene sequence:

>918_bases
ATGAGCGCGCCGTCCGGCTGGGCAACGAGTCAGGGCACGCTGGCACGTCCGCTGGCGATCGACGGTCACGGGCTGCACAC
GGGGCGCCGGGTGGGCGTGCGGATCCTGCCCGTGCGTCCGGAAGAGGGTGTGACGGGGATCGCGTTCCGTCGCGTCGCGC
AGGGGCGCACGCTCGCGACGCTGCCGGTCGATCCCGCGCTGCGCCGCGCGCAGCCGCTGTGCACGATGCTGCGCAACGCC
GACGGCGTCGGCGTTCGCACGATCGAGCATCTGCTCGCATCGCTGCTCGCGTGCGAGATCGATCATGCGATCGTCGAGAT
CGATGCCGAGGAAGTGCCGATTCTCGATGGCAGCGCTGCGCCTTGGGTGGATGCCATCCGCGCGTGCGGCCGGGTCGCGC
TCGATGCGCCGAAACGCTTCATCCGCGTGCTGCGGCCCGTCGTCGTCACGGACGGCGAGGGCGACCAGCGGCGCGAAATG
CGGATCGAACCGGCGCCGCGTTACGAACTGAGCGTGCGCAACGACCTGCGCGGCTTCGGCGACATGCACTGGGACGGTGC
GCTGACGCCGGCCGCATTTGCGACCGAAATCGCGCCGTCGCGCTCGTACGGCCGCGTGAAGTGGGCGGTACCCGCGATCG
TCGCCGGTTACCTGCGCGGGGTGCCGATCCTGCGCGGCGCGCGGCCGTCGTGCACCGCGTCCATCGTCGGCAATCGCGTG
CTGGGCGGGATGCGGCTGCCGGAAGAGTTCGTCCGGCATCGCGTGCTCGACCTGGTCGGCGATCTGGCGCTGGCCGGCGC
GCCGCTGCTGGCGCGCGTGAGCGCGCTGCGGCCGAGCCACGAGATGAATTTCCGGCTGGTGGACGCGCTGCTGGCCGAAC
CGGATGCGTGGCAGTGGGCCGAGTTTCCCGACGCGTGA

Upstream 100 bases:

>100_bases
TCGCGGCGAAGCATGCGATCGACGGCGAAGCGCGTGCGATGCTCGATACGCGGCAGGCGCCCGTCGCGGGCCAGGCGTCG
CCGACGCTGGAGGTCGCGCG

Downstream 100 bases:

>100_bases
CACCACGCTTTTTCATGACGCGCGGCGTAACATAGCGTCTTTTCGAGATACAGCGAAGGAAGCAATGGCACTGGGAGAGC
ATCTTCGCCAGCAACTGGCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSAPSGWATSQGTLARPLAIDGHGLHTGRRVGVRILPVRPEEGVTGIAFRRVAQGRTLATLPVDPALRRAQPLCTMLRNA
DGVGVRTIEHLLASLLACEIDHAIVEIDAEEVPILDGSAAPWVDAIRACGRVALDAPKRFIRVLRPVVVTDGEGDQRREM
RIEPAPRYELSVRNDLRGFGDMHWDGALTPAAFATEIAPSRSYGRVKWAVPAIVAGYLRGVPILRGARPSCTASIVGNRV
LGGMRLPEEFVRHRVLDLVGDLALAGAPLLARVSALRPSHEMNFRLVDALLAEPDAWQWAEFPDA

Sequences:

>Translated_305_residues
MSAPSGWATSQGTLARPLAIDGHGLHTGRRVGVRILPVRPEEGVTGIAFRRVAQGRTLATLPVDPALRRAQPLCTMLRNA
DGVGVRTIEHLLASLLACEIDHAIVEIDAEEVPILDGSAAPWVDAIRACGRVALDAPKRFIRVLRPVVVTDGEGDQRREM
RIEPAPRYELSVRNDLRGFGDMHWDGALTPAAFATEIAPSRSYGRVKWAVPAIVAGYLRGVPILRGARPSCTASIVGNRV
LGGMRLPEEFVRHRVLDLVGDLALAGAPLLARVSALRPSHEMNFRLVDALLAEPDAWQWAEFPDA
>Mature_304_residues
SAPSGWATSQGTLARPLAIDGHGLHTGRRVGVRILPVRPEEGVTGIAFRRVAQGRTLATLPVDPALRRAQPLCTMLRNAD
GVGVRTIEHLLASLLACEIDHAIVEIDAEEVPILDGSAAPWVDAIRACGRVALDAPKRFIRVLRPVVVTDGEGDQRREMR
IEPAPRYELSVRNDLRGFGDMHWDGALTPAAFATEIAPSRSYGRVKWAVPAIVAGYLRGVPILRGARPSCTASIVGNRVL
GGMRLPEEFVRHRVLDLVGDLALAGAPLLARVSALRPSHEMNFRLVDALLAEPDAWQWAEFPDA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=301, Percent_Identity=31.5614617940199, Blast_Score=152, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33056; Mature: 32924

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSGWATSQGTLARPLAIDGHGLHTGRRVGVRILPVRPEEGVTGIAFRRVAQGRTLAT
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEE
LPVDPALRRAQPLCTMLRNADGVGVRTIEHLLASLLACEIDHAIVEIDAEEVPILDGSAA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHEEEECCCCCCEECCCCC
PWVDAIRACGRVALDAPKRFIRVLRPVVVTDGEGDQRREMRIEPAPRYELSVRNDLRGFG
HHHHHHHHHCHHHHHHHHHHHHHHHCEEEECCCCCCHHCEECCCCCCEEEEHHHHHCCCC
DMHWDGALTPAAFATEIAPSRSYGRVKWAVPAIVAGYLRGVPILRGARPSCTASIVGNRV
CCCCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGGMRLPEEFVRHRVLDLVGDLALAGAPLLARVSALRPSHEMNFRLVDALLAEPDAWQWA
HCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
EFPDA
CCCCC
>Mature Secondary Structure 
SAPSGWATSQGTLARPLAIDGHGLHTGRRVGVRILPVRPEEGVTGIAFRRVAQGRTLAT
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEE
LPVDPALRRAQPLCTMLRNADGVGVRTIEHLLASLLACEIDHAIVEIDAEEVPILDGSAA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHEEEECCCCCCEECCCCC
PWVDAIRACGRVALDAPKRFIRVLRPVVVTDGEGDQRREMRIEPAPRYELSVRNDLRGFG
HHHHHHHHHCHHHHHHHHHHHHHHHCEEEECCCCCCHHCEECCCCCCEEEEHHHHHCCCC
DMHWDGALTPAAFATEIAPSRSYGRVKWAVPAIVAGYLRGVPILRGARPSCTASIVGNRV
CCCCCCCCCHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGGMRLPEEFVRHRVLDLVGDLALAGAPLLARVSALRPSHEMNFRLVDALLAEPDAWQWA
HCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
EFPDA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA