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The map label for this gene is hemH

Identifier: 78065309

GI number: 78065309

Start: 741495

End: 742559

Strand: Direct

Name: hemH

Synonym: Bcep18194_A3835

Alternate gene names: 78065309

Gene position: 741495-742559 (Clockwise)

Preceding gene: 78065306

Following gene: 78065310

Centisome position: 20.07

GC content: 68.64

Gene sequence:

>1065_bases
ATGCGTTTCGATCTTGAGCCGCCTTCGAGCACCGCGGCTGCCCATCGCATCGGTGTGCTGCTGATCAATCTCGGCACGCC
CGACGCCCCTACGCCGCGCGCGGTGCGGCGCTACCTGGCCGAATTCCTGTCGGATCCGCGGGTCGTCGAGATTCCGCAGG
CCGTCTGGCAGGTGCTGCTGCGCACGCTGATCCTGCCGCTGCGCGGCCGCGCGTCCGCAAAGAAATACGCAGCCGTCTGG
ATGCCCGAGGGCTCGCCGCTGCGTGTGTACACGGAGCGCCAGACGGACAGCGTGCGGCATCTGCTCACGTCGAACGGCTA
TCACGTGATGGTCGATTACGCGATGCGCTACGGCAGCCCGAACATTTCGCACGCGCTCGCGCAGTTCAAGCGTGCGGGCG
TCGAGCGCGTGCTGCTGATGCCGATGTATCCGCAATACTCGGCGTCGACCACGGCCACCGCCTTCGACGCCGCTTTCGAC
GCGCTCGCGCGCATGCGCAACCAGCCCGAGGTACGCACGGTGCGGCACTACGCCGACCATCCGGCCTATATCCATGCGCT
GGCCGAGCAGGTGCGCCAGTATTGGGCGCAGCACGGCCGGCCCGATTTCGCGGCCGGCGACAAGCTCGTGCTGAGCTTTC
ACGGCGTGCCGAAGCGCACGCTCGACCTCGGCGACCCCTATCACGACCAGTGCCAGCAGACGGGTGCGCTGCTGACGGCC
GCGCTCGGGCTGTCGACGACCGAGTGCCGCGTCACGTTCCAGTCGCGTTTCGGCAAGGCCGAATGGCTGCAGCCTTACAC
CGCGCCGACGCTGCGCGAGTTCGGCGAGGCCGGCGTGCGGCGCGCCGACGTGTTCTGTCCCGGTTTCACGGCCGACTGCC
TGGAGACGATCGAGGAGATCGGCATGGAAGTGCGCGACGAGTTCCTCGCCGGCGGCGGCAAGGCGTTCCACCGCATTCCG
TGCCTGAACGGTGCGCCCGCGTGGATCGGCGCGCTCGGCGAGATCGTCGCCGAGAATCTGCAGGGCTGGCCGGTCAGGGC
CGCGCAGCCCGAAACGGTGAGCTGA

Upstream 100 bases:

>100_bases
GCGTAAGCAGGCAGTCGGCCGAACGGCCAGCCGACCGGTGCGGGGCGGCCCGCTATAATTGAGAGCCGTCCGGTCCCGTG
CCCCGAGCACGTAATTGCCC

Downstream 100 bases:

>100_bases
GATGAAACGACCCCCACGCTCACTTCGTTCACTGCCCCCCGAGGGGGCGGTCAGCCTCCTTGGGGCGGCCCGGCGGAGGC
TGCGATGAATTACAAGATTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRFDLEPPSSTAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLTA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKAFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRAAQPETVS

Sequences:

>Translated_354_residues
MRFDLEPPSSTAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLTA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKAFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRAAQPETVS
>Mature_354_residues
MRFDLEPPSSTAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLTA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKAFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRAAQPETVS

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=270, Percent_Identity=25.5555555555556, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI60499021, Length=270, Percent_Identity=25.5555555555556, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=46.2732919254658, Blast_Score=283, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=24.2690058479532, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=24.9266862170088, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=24.8148148148148, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39286; Mature: 39286

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSSTAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLL
CCCCCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEHHHHCCCC
NISHALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFDALARMRNQPEVRTVRHYADH
CHHHHHHHHHHHCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLTA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEI
HHCCCCHHHEEEHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFLAGGGKAFHRIPCLNGAPAWIGALGEIVAENLQGWPVRAAQPETVS
HHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLEPPSSTAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLL
CCCCCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEHHHHCCCC
NISHALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFDALARMRNQPEVRTVRHYADH
CHHHHHHHHHHHCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLTA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEI
HHCCCCHHHEEEHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFLAGGGKAFHRIPCLNGAPAWIGALGEIVAENLQGWPVRAAQPETVS
HHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA