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The map label for this gene is pepP [H]

Identifier: 78065257

GI number: 78065257

Start: 675999

End: 677384

Strand: Reverse

Name: pepP [H]

Synonym: Bcep18194_A3781

Alternate gene names: 78065257

Gene position: 677384-675999 (Counterclockwise)

Preceding gene: 78065259

Following gene: 78065256

Centisome position: 18.34

GC content: 70.35

Gene sequence:

>1386_bases
ATGAACGCGCCCCTCGATACCGCCATCGCCGTCGACGTCTACCGCCAGCGCCGTGAACGCGTGCTTGCCGCACTGCGTGC
CGCCGGCGGCGGCGTCGCCATCGTCCCCACCGCGCCCGAAGTGCCGCGCAACCGCGATACGGACTATCCGTACCGGTTCG
ACAGCTACTTCCACTACCTGACGGGCTTCAGCGAGCCGGATGCCGTGCTCGTGCTGAACGCGGCCGCGCCGCACGGCGCG
CCGGAATCGATCCTGTTCTGCCGCGGCAAGAATGTCGACCGCGAGATCTGGGAAGGCTTCCACTACGGGCCCGAAGCCGC
GCGCGACGCATTCGGCTTCGACGCGGCGTTCGCGGTCGACGTGATCGATACCGAGATGCCGCGCCTGCTCGCCGACGCGG
GCACCGTGCACTACCGGTTCGGCGCATCGGCCGACTTCGATCGCCAGCTCGCGGGCTGGATCGACGCGGTGCGCGCGCTG
GCGCGCTCGGGTGTCGCCGCGCCGGACGCGATGCTCGACCTCACGCCGCTGCTCGACGACATGCGGCTCGTGAAGGACGA
GCACGAACTCGCGATCATGATGCGCGCCGCGCACATCTCCGCGCTCGCGCACCGCCGCGCGATGCAGGCGTGCCGCCCCG
GCGTCCGCGAATACGAACTCGAGGCCGAGCTGCTGTACGTATTCCGCAAGCACGGCGCGCAGTCGCCCGCGTACGGCTCG
ATCGTCGCGGCCGGCGCGAACGCGTGCGTGCTGCACTACCCGGCCGGCAACGCGACCGCGAAAGATGGCGACCTGATCCT
GATCGACGCCGCGTGCGAACTCGACGGCTACGCGTCGGACATCACGCGCACGTTCCCGGCCAACGGGCGCTTCTCGCCCG
CGCAACGCACGCTGTACGACATCGTGCTCGCCGCGCAGCAGGCCGCGATCGATGCGACGCGTGCCGGCGTGCCGTTCGAG
GCGCCGCACGACGCCGCCGTGCGCGTGCTCGCGCAGGGGCTGCTCGACACCGGCATCATCCCGAAATCGCGCTTCTCGAA
CGTCGACGACGTGATCGCCGAGCGCGCCTACGCGCGCTTCTACATGCACCGCACCGGCCACTGGATCGGCATGGACGTGC
ACGATTGCGGCGACTACCGCGAACGGCTCGCCGAGCGTGACGGCAACGGCGTGCTGCCGTGGCGCACGCTGAAAGCCGGC
ATGACGCTGACGATCGAGCCCGGCCTGTACGTGCGCGCCGCCGACGACGTGCCGCCCGAGTACTGGAACATCGGCATCCG
CATCGAGGACGACGCGATCGTGCGCGAGCACGGCTGCGAACTGATCACGCGCGGCGTGCCCGTCGCAGCGGACGAGATCG
AAGCGCTGATGCGCGCAGGCGCATGA

Upstream 100 bases:

>100_bases
GGCCTGTGGATGGTTTGCAACAACCGCCGCGCGGGCCTTCCAGGGCGGCTTCCCGCCCCCTCTCTCACGCACGGCGTCCC
GCGGCGCTACAATCGCACGA

Downstream 100 bases:

>100_bases
CCGGCTGCAGCCGACCGTTACCACCGTTTCACGAATCAAGATGACGACCGCTTCCTCCCCGGCCACGCCGGACTACGACC
TCGCCATCGTCGGCGCGGGC

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVPRNRDTDYPYRFDSYFHYLTGFSEPDAVLVLNAAAPHGA
PESILFCRGKNVDREIWEGFHYGPEAARDAFGFDAAFAVDVIDTEMPRLLADAGTVHYRFGASADFDRQLAGWIDAVRAL
ARSGVAAPDAMLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQACRPGVREYELEAELLYVFRKHGAQSPAYGS
IVAAGANACVLHYPAGNATAKDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKSRFSNVDDVIAERAYARFYMHRTGHWIGMDVHDCGDYRERLAERDGNGVLPWRTLKAG
MTLTIEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRAGA

Sequences:

>Translated_461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVPRNRDTDYPYRFDSYFHYLTGFSEPDAVLVLNAAAPHGA
PESILFCRGKNVDREIWEGFHYGPEAARDAFGFDAAFAVDVIDTEMPRLLADAGTVHYRFGASADFDRQLAGWIDAVRAL
ARSGVAAPDAMLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQACRPGVREYELEAELLYVFRKHGAQSPAYGS
IVAAGANACVLHYPAGNATAKDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKSRFSNVDDVIAERAYARFYMHRTGHWIGMDVHDCGDYRERLAERDGNGVLPWRTLKAG
MTLTIEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRAGA
>Mature_461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVPRNRDTDYPYRFDSYFHYLTGFSEPDAVLVLNAAAPHGA
PESILFCRGKNVDREIWEGFHYGPEAARDAFGFDAAFAVDVIDTEMPRLLADAGTVHYRFGASADFDRQLAGWIDAVRAL
ARSGVAAPDAMLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQACRPGVREYELEAELLYVFRKHGAQSPAYGS
IVAAGANACVLHYPAGNATAKDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKSRFSNVDDVIAERAYARFYMHRTGHWIGMDVHDCGDYRERLAERDGNGVLPWRTLKAG
MTLTIEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRAGA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=452, Percent_Identity=29.646017699115, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI149589008, Length=491, Percent_Identity=29.7352342158859, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI260593665, Length=309, Percent_Identity=35.5987055016181, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI260593663, Length=478, Percent_Identity=27.1966527196653, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789275, Length=453, Percent_Identity=40.8388520971302, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1788728, Length=276, Percent_Identity=31.1594202898551, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790282, Length=296, Percent_Identity=30.0675675675676, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=483, Percent_Identity=31.2629399585921, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71989583, Length=378, Percent_Identity=26.7195767195767, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320922, Length=423, Percent_Identity=27.8959810874704, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321118, Length=443, Percent_Identity=29.3453724604966, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19920384, Length=400, Percent_Identity=34.75, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI21357079, Length=494, Percent_Identity=31.1740890688259, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50402; Mature: 50402

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVPRNRDTDYPYRFDSYFHYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHH
TGFSEPDAVLVLNAAAPHGAPESILFCRGKNVDREIWEGFHYGPEAARDAFGFDAAFAVD
CCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHCCCCCCHHHHHHHCCCCCEEEEE
VIDTEMPRLLADAGTVHYRFGASADFDRQLAGWIDAVRALARSGVAAPDAMLDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMMRAAHISALAHRRAMQACRPGVREYELEAELLYVFRKHGAQSPAYGS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IVAAGANACVLHYPAGNATAKDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIPKSRFSNVDDVIAERAYARF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHH
YMHRTGHWIGMDVHDCGDYRERLAERDGNGVLPWRTLKAGMTLTIEPGLYVRAADDVPPE
HHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRAGA
CEEEEEEECCCHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVPRNRDTDYPYRFDSYFHYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHH
TGFSEPDAVLVLNAAAPHGAPESILFCRGKNVDREIWEGFHYGPEAARDAFGFDAAFAVD
CCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHCCCCCCHHHHHHHCCCCCEEEEE
VIDTEMPRLLADAGTVHYRFGASADFDRQLAGWIDAVRALARSGVAAPDAMLDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMMRAAHISALAHRRAMQACRPGVREYELEAELLYVFRKHGAQSPAYGS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IVAAGANACVLHYPAGNATAKDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIPKSRFSNVDDVIAERAYARF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHH
YMHRTGHWIGMDVHDCGDYRERLAERDGNGVLPWRTLKAGMTLTIEPGLYVRAADDVPPE
HHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRAGA
CEEEEEEECCCHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]