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The map label for this gene is manB [H]

Identifier: 78049581

GI number: 78049581

Start: 4621195

End: 4623540

Strand: Reverse

Name: manB [H]

Synonym: XCV4025

Alternate gene names: 78049581

Gene position: 4623540-4621195 (Counterclockwise)

Preceding gene: 78049582

Following gene: 78049571

Centisome position: 89.28

GC content: 67.86

Gene sequence:

>2346_bases
ATGAGCAAGGCGAACGAGCGCAGGCAGGGGATGTCCAGCGTGCGTACGAGTGGTCCGGTGTTGGGAGGCATGTTGCTGCT
GCTGGCTGCCTGGTTCGGCTGGAACAGTTATGCGCAATGGCGCCAGGACGCGGTGGCGCAAGGGCTGGAGCAGGCGCGCG
ACCGCGCGGTGCAGGACGTGGGCCAGGCCATGGCCACCCAGGCCAGCCAGCTCGACGCGGTGCTCAAGCAGCCGCCGGTC
ATCGCTGCGTTGGCCGGTGGCGACGCGCTGGCGGCCGCATCGGCCATCCGCGAGCGCTTCAAGGGCGCCGAGGATGTGCA
GGTGCTGCCTGGCGACCTTGCCGCGGCCTATGCCAACCCCAAGGATTTCGGTTACGCGCGTCTGAGCCTGCTCGAATCGG
CGCAGGTGGCCGACCGGGCGCAGGTCCGGGTGGTACGCGAGGCCAAACAAGTCCGCCTGGGCGTGGCTGCCGCGGTGCGC
CTTGGCGGGCAGCCGGCGGTGGCGTATGCGCGGTTGCCGTTACTGCGCCTGACCGGCCCGCTGGATGCAATCGCGGCACC
GGACAGCGCCTACCTGGCCGTGCGCCAGGGCAGCTACAACGTGGCCCAGCAGGGCGATATGGCACTGGCCGATGCGGCCG
AAACGCTGGCAAGGCCGCTTGGGACCAGCGGCTTGCGCGTGGCTGCGGCGGTGCCGCAAGGCGACAGCGGCCCACTGGGC
CTGGGCGCCGTCGGTTGCGCCATCGTGGCGGCATTGCTGCTGATCATTGCGGTACTGCTGGTGCTGGCCAGCCGGGGTCA
GGTGGCCTTGCCACGGCGCCGGGTTGCCGACCAATCCGGCGCCGATGAACCCACCTTCAGTCAGAGCCTGCAGCACGACG
CCAGCGTTGCCAGCGAGGCACGCGCGCTGGACGCCGAGGCACCGCCGGCACCGCCAGCGCTGGTGCCGGCGGTGCAGGTC
GCCACCGAGATGTTCCGTGCCTACGACATCCGCGGCGTGGTCGGTAAGGACCTCAACCCCGGCGTTGCCGCCTTGGTGGG
CCAGGCCATCGGCAGCGTGATGCAGGCGCAGGGACTGCGCGATGTGGTGGTCGGTCGCGACGGCCGGCTGTCCGGGCCGG
AGCTGAGCAACGGCCTGATCGAAGGCCTGCGCCGCGCCGGCTGCAACGTCACCGACATCGGCCTGGCACCGACGCCGGTG
GTGTACTTCGGCGCCTACGAGCTGCGTGCCGGCAGCTGCGTGGCGGTCACCGGCAGCCACAATCCGCCGGACTACAACGG
TTTCAAGATCGTGATCGGCGGCGAGACCTTGTCCGGCGCCGCCATCGCCGAACTGCACCAGCGCATCAACGAAGGTCGCC
TGCATACCGCCGCCACGCCTGGCGAACTGGAACAGCGCGACATCAGCGATGCCTACATCCAGCGTATCGCCGATGACGTC
CAGCTCGATCGCCCGATCAAGGTGGTGGTGGACGCCGGCAACGGCGTGGCCGGTGAGATCGCGCCGCGCCTGCTGGAAGC
GATCGGCGCCGAAGTGGTGCCGTTGTACTGCGACATCGATGGCACCTTCCCCAACCATCACCCTGATCCGAGCGAGCCGC
ACAACCTCAACGATCTGGTGAAGATGGTGCAGCGTTTCGATGCGGATATCGGCGTGGCGTTCGATGGCGATGCCGATCGC
CTGGGCGTGGTGACCAAGGAAGGCGCGATGGTGTTCCCCGACCGCCTGCTGATGCTGTTCGCCGCCGATGTCCTGCAGCG
CAACCCTGGCGCATTGGTCATCTACGACGTGAAGTGCACCGGCAAGCTGTCCGACTACGTGTTGCGCAATGGCGGTAGTC
CGCTGATGTGGAAGACCGGGCATTCGCTGATCAAATCCAAGATGCGCGAGACCGATGCTGAGCTGGCCGGCGAGATGAGC
GGCCACTTCTTCTTCAAGGAGCGCTGGTACGGCTTTGACGACGGCATCTACGCCGCCGCACGCCTGCTGGAAATCCTGGC
CCAGCGCGAGGAAACCCCGTCCGACGTGCTGGACGCCCTGCCCGAGAGCGTCTCCACGCCGGAGATCAAGGTGCCGGTGG
AAGGCGATGCGCATGCGCTGGTGGCGCGCTTTGTCGCGCGTGCGCAGACCGGCGAAGAATCGCCGTTCGAATCGGCGCGG
CTGTCGACCATCGACGGGCTGCGCGCGGACTTCATCGACGGCTGGGGGCTGGTACGCGCCTCCAATACAACGCCGATCCT
GGTGCTGCGGTTCGAAGCCGACAGCGAGGCCGCATTGCAGCGGATTCGCACGCTGTTCCGCAACGAACTGCAGACGTTGT
TGCCGGAGCATCCATTGGCGTTTTGA

Upstream 100 bases:

>100_bases
ATCGTGCGTATGGGCTTGCAAGTGGTGGATACTTTCGTCGACAGCGCGCGGGGAGCGGGTGGATTCGGCCACACCGGCGT
GCGCTGACAGGGGAAATTAC

Downstream 100 bases:

>100_bases
TCGCCGGATGCGCGGACCGTCCGCTGCGTTGCCTGGGCAGGGGCAGGGGCAGCGCAGCTGGGCCGGCGGGCGACGCGGCG
GGCCGTTATCCGGCTCGCTT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MSKANERRQGMSSVRTSGPVLGGMLLLLAAWFGWNSYAQWRQDAVAQGLEQARDRAVQDVGQAMATQASQLDAVLKQPPV
IAALAGGDALAAASAIRERFKGAEDVQVLPGDLAAAYANPKDFGYARLSLLESAQVADRAQVRVVREAKQVRLGVAAAVR
LGGQPAVAYARLPLLRLTGPLDAIAAPDSAYLAVRQGSYNVAQQGDMALADAAETLARPLGTSGLRVAAAVPQGDSGPLG
LGAVGCAIVAALLLIIAVLLVLASRGQVALPRRRVADQSGADEPTFSQSLQHDASVASEARALDAEAPPAPPALVPAVQV
ATEMFRAYDIRGVVGKDLNPGVAALVGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAPTPV
VYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDV
QLDRPIKVVVDAGNGVAGEIAPRLLEAIGAEVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGDADR
LGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAGEMS
GHFFFKERWYGFDDGIYAAARLLEILAQREETPSDVLDALPESVSTPEIKVPVEGDAHALVARFVARAQTGEESPFESAR
LSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHPLAF

Sequences:

>Translated_781_residues
MSKANERRQGMSSVRTSGPVLGGMLLLLAAWFGWNSYAQWRQDAVAQGLEQARDRAVQDVGQAMATQASQLDAVLKQPPV
IAALAGGDALAAASAIRERFKGAEDVQVLPGDLAAAYANPKDFGYARLSLLESAQVADRAQVRVVREAKQVRLGVAAAVR
LGGQPAVAYARLPLLRLTGPLDAIAAPDSAYLAVRQGSYNVAQQGDMALADAAETLARPLGTSGLRVAAAVPQGDSGPLG
LGAVGCAIVAALLLIIAVLLVLASRGQVALPRRRVADQSGADEPTFSQSLQHDASVASEARALDAEAPPAPPALVPAVQV
ATEMFRAYDIRGVVGKDLNPGVAALVGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAPTPV
VYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDV
QLDRPIKVVVDAGNGVAGEIAPRLLEAIGAEVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGDADR
LGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAGEMS
GHFFFKERWYGFDDGIYAAARLLEILAQREETPSDVLDALPESVSTPEIKVPVEGDAHALVARFVARAQTGEESPFESAR
LSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHPLAF
>Mature_780_residues
SKANERRQGMSSVRTSGPVLGGMLLLLAAWFGWNSYAQWRQDAVAQGLEQARDRAVQDVGQAMATQASQLDAVLKQPPVI
AALAGGDALAAASAIRERFKGAEDVQVLPGDLAAAYANPKDFGYARLSLLESAQVADRAQVRVVREAKQVRLGVAAAVRL
GGQPAVAYARLPLLRLTGPLDAIAAPDSAYLAVRQGSYNVAQQGDMALADAAETLARPLGTSGLRVAAAVPQGDSGPLGL
GAVGCAIVAALLLIIAVLLVLASRGQVALPRRRVADQSGADEPTFSQSLQHDASVASEARALDAEAPPAPPALVPAVQVA
TEMFRAYDIRGVVGKDLNPGVAALVGQAIGSVMQAQGLRDVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAPTPVV
YFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDVQ
LDRPIKVVVDAGNGVAGEIAPRLLEAIGAEVVPLYCDIDGTFPNHHPDPSEPHNLNDLVKMVQRFDADIGVAFDGDADRL
GVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAGEMSG
HFFFKERWYGFDDGIYAAARLLEILAQREETPSDVLDALPESVSTPEIKVPVEGDAHALVARFVARAQTGEESPFESARL
STIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHPLAF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=464, Percent_Identity=32.9741379310345, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI1789566, Length=452, Percent_Identity=28.7610619469027, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 82816; Mature: 82685

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKANERRQGMSSVRTSGPVLGGMLLLLAAWFGWNSYAQWRQDAVAQGLEQARDRAVQDV
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQAMATQASQLDAVLKQPPVIAALAGGDALAAASAIRERFKGAEDVQVLPGDLAAAYANP
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCC
KDFGYARLSLLESAQVADRAQVRVVREAKQVRLGVAAAVRLGGQPAVAYARLPLLRLTGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCCC
LDAIAAPDSAYLAVRQGSYNVAQQGDMALADAAETLARPLGTSGLRVAAAVPQGDSGPLG
HHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
LGAVGCAIVAALLLIIAVLLVLASRGQVALPRRRVADQSGADEPTFSQSLQHDASVASEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RALDAEAPPAPPALVPAVQVATEMFRAYDIRGVVGKDLNPGVAALVGQAIGSVMQAQGLR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
DVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSH
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEECCEEECCCCEEEEECCC
NPPDYNGFKIVIGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
QLDRPIKVVVDAGNGVAGEIAPRLLEAIGAEVVPLYCDIDGTFPNHHPDPSEPHNLNDLV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHH
KMVQRFDADIGVAFDGDADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCT
HHHHHHCCCCEEEECCCCCCCCEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAA
CCHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCHHHHHH
RLLEILAQREETPSDVLDALPESVSTPEIKVPVEGDAHALVARFVARAQTGEESPFESAR
HHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHH
LSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHPLA
HHHHCCCHHHHHCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
F
C
>Mature Secondary Structure 
SKANERRQGMSSVRTSGPVLGGMLLLLAAWFGWNSYAQWRQDAVAQGLEQARDRAVQDV
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQAMATQASQLDAVLKQPPVIAALAGGDALAAASAIRERFKGAEDVQVLPGDLAAAYANP
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCC
KDFGYARLSLLESAQVADRAQVRVVREAKQVRLGVAAAVRLGGQPAVAYARLPLLRLTGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHCCCC
LDAIAAPDSAYLAVRQGSYNVAQQGDMALADAAETLARPLGTSGLRVAAAVPQGDSGPLG
HHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
LGAVGCAIVAALLLIIAVLLVLASRGQVALPRRRVADQSGADEPTFSQSLQHDASVASEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
RALDAEAPPAPPALVPAVQVATEMFRAYDIRGVVGKDLNPGVAALVGQAIGSVMQAQGLR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
DVVVGRDGRLSGPELSNGLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSH
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEECCEEECCCCEEEEECCC
NPPDYNGFKIVIGGETLSGAAIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
QLDRPIKVVVDAGNGVAGEIAPRLLEAIGAEVVPLYCDIDGTFPNHHPDPSEPHNLNDLV
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHH
KMVQRFDADIGVAFDGDADRLGVVTKEGAMVFPDRLLMLFAADVLQRNPGALVIYDVKCT
HHHHHHCCCCEEEECCCCCCCCEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAA
CCHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCHHHHHH
RLLEILAQREETPSDVLDALPESVSTPEIKVPVEGDAHALVARFVARAQTGEESPFESAR
HHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHH
LSTIDGLRADFIDGWGLVRASNTTPILVLRFEADSEAALQRIRTLFRNELQTLLPEHPLA
HHHHCCCHHHHHCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]