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The map label for this gene is thrS [H]

Identifier: 78048351

GI number: 78048351

Start: 3174580

End: 3176484

Strand: Reverse

Name: thrS [H]

Synonym: XCV2795

Alternate gene names: 78048351

Gene position: 3176484-3174580 (Counterclockwise)

Preceding gene: 78048353

Following gene: 78048350

Centisome position: 61.34

GC content: 63.88

Gene sequence:

>1905_bases
ATGATCAACATCACGCTTCCCGACGGCAGCCGCCGCGAATTCGAATCCCCCGTCTCGGTGATGCAGGTCGCCCAGTCGAT
CGGCGCCGGCTTGGCCAAGGCCACCATCGCCGGCCAGGTCGACGGCCAGCTGGTCGATGCCAGCGACGTCATCGACCACG
ATGCCAGCCTGCGCATCATCACCGCCAAGGACGCCGAAGGCGTGGAGATCATCCGCCACTCCTGCGCCCACCTGGTCGGG
CATGCGGTCAAGCAGCTGTACCCGGAGGTCAAGATGGTGATCGGCCCGGTCATCGCCGAAGGCTTCTATTACGACATCTA
CAGCGAACGCCCGTTCACGCCGGACGACATGGCCGCGATCGAGCAGCGCATGCAGGAATTGATCGCGCAGGACTACGACG
TGATCAAGAAGGTCACCCCGCGCGCCGAGGTGATCGAGGTCTTCGCCCAGCGCGGCGAAGAGTACAAGCTGCGCCTGATC
GAGGACATGTCCGAGGACATCACCGCGATGGGCCTGTACTACCACCAGGAATACGTGGACATGTGCCGCGGCCCGCACGT
GCCCAACACGCGCTTCCTCAAGGCCTTCAAGCTGACCCGCATCTCCGGCGCCTACTGGCGCGGCGATGCCAAGAACGAGC
AACTACAGCGCATCTACGGCACCGCCTGGGCCGACAAGAAACAGCTGGATGCCTACATCCTGCGCATGGAAGAAGCCGAC
AAGCGCGACCATCGCCGCATCGGCAAGGCGCAGGACCTGTTCCACCTGCAGGAAGAAGCACCCGGCCTGGTGTTCTGGCA
CCCCAAGGGCTGGTCGCTGTGGCAGGTGGTCGAGCAGTACATGCGCAAGGTCTACCGCGACAGCGGCTACGGCGAAGTGC
GCTGCCCGCAGATCCTGGACGTGTCGCTGTGGCAGAAATCCGGCCACTGGGACAACTACCAGGACGCGATGTTCTTCACC
GAGTCGGAGAAGCGCACCTACGCGGTCAAGCCGATGAACTGCCCCGGCCACGTGCAGGTGTTCAACCAGGGCCTGCACAG
CTACCGCGACCTGCCGATCCGCTACGGCGAGTTCGGCGCCTGCCACCGCAACGAGCCTTCCGGCGCGCTGCACGGCATCC
TGCGCGTGCGCGGCTTCACCCAGGACGACGGGCACGTGTTCTGCCTGGAATCGCAGATCGAATCCGAAGTCACCGCCTTC
CACCAGCAGGCGCTGGCGGTCTATACCGCGTTCGGCTTCGACGACATCCAGATCAAGATCGCGCTGCGTCCGGAAAAGCG
CCTGGGCGACGATGCCACCTGGGACAAGGCCGAAGCTGCGCTACGCAGCGCGCTGGGCGTGTGCGGGGTGGAGTGGCAGG
AGCTGCCGGGCGAGGGTGCCTTCTACGGCCCCAAGATCGAGTACCACCTCAAGGACGCCATCGGCCGCACCTGGCAGCTG
GGCACCATGCAGGTCGACTTCATGATGCCGGGCCGCCTCGGCGCCGAGTACGTGGACGAGAACAGCCAGAAGAAGCATCC
GGTCATGCTGCACCGGGCCATCGTCGGCTCGATGGAGCGTTTCATCGGCATTTTGATCGAACACCACGCCGGTGCCTTCC
CGTCCTGGCTGGCCCCGGTGCAGGTCGTTGTCGCCAACATCACCGATGCTCAGGCTGAATATGTCGACTCGGTGCGGAAA
ACCCTTGCAAATCAAGGCTTCCGTGTCAGCGCAGATTTGCGTAACGAGAAGATCGGTTATAAGATTCGCGAGCATACGCT
GCAACGCGTGCCATATCTGCTCGTGGTCGGCGACCGCGAGAAGGAAAATGGCGCTGTCGCCGTGCGGACCCGTTCAGGCG
AGGACCTTGGGACCATGACGGTCTCGGCCTTCATCGAACGTCTGCAGGCAGAGCAGGCAGCGTGA

Upstream 100 bases:

>100_bases
CTTGCCTCTCGTCCCGCATTTCCCTCCGAGCCTGACCAGCGATGGCCAGATCTCCCATGGCAGCCGACCGCTGCAGCCAG
ACCAGACCTCATTCTTGCCC

Downstream 100 bases:

>100_bases
GCCAACCCCGGCCGGTCTGGATGATCCGGATGCGCCGGTTCGATTCCTCTGGGAGATTGCAATATCAGTACCACTGACAA
CAAACAGAACCGCAAGAACC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRIITAKDAEGVEIIRHSCAHLVG
HAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPDDMAAIEQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLI
EDMSEDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEAD
KRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMFFT
ESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIESEVTAF
HQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQL
GTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPVQVVVANITDAQAEYVDSVRK
TLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA

Sequences:

>Translated_634_residues
MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRIITAKDAEGVEIIRHSCAHLVG
HAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPDDMAAIEQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLI
EDMSEDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEAD
KRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMFFT
ESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIESEVTAF
HQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQL
GTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPVQVVVANITDAQAEYVDSVRK
TLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
>Mature_634_residues
MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRIITAKDAEGVEIIRHSCAHLVG
HAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPDDMAAIEQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLI
EDMSEDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEAD
KRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMFFT
ESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIESEVTAF
HQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQL
GTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPVQVVVANITDAQAEYVDSVRK
TLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=39.2405063291139, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=633, Percent_Identity=37.5987361769352, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=34.8765432098765, Blast_Score=391, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=628, Percent_Identity=60.9872611464968, Blast_Score=832, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=157, Percent_Identity=24.8407643312102, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=38.0503144654088, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=38.0503144654088, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322112, Length=629, Percent_Identity=37.5198728139905, Blast_Score=445, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322654, Length=413, Percent_Identity=36.0774818401937, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24583842, Length=632, Percent_Identity=39.5569620253165, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI28574141, Length=632, Percent_Identity=39.5569620253165, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583839, Length=632, Percent_Identity=39.5569620253165, Blast_Score=487, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 71841; Mature: 71841

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRII
CEEEECCCCCCHHHHCHHHHHHHHHHHCCCHHHHHEECCCCCEEECHHHHHCCCCCEEEE
TAKDAEGVEIIRHSCAHLVGHAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPDDMAAI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHH
EQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLIEDMSEDITAMGLYYHQEYVD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
MCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEAD
HHCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILD
HHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCHHHH
VSLWQKSGHWDNYQDAMFFTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGA
HHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
CHRNEPSGALHGILRVRGFTQDDGHVFCLESQIESEVTAFHQQALAVYTAFGFDDIQIKI
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEECCCEEEEEE
ALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQL
EECCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCEEEEEEHHHCCCEEEE
GTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPV
CEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QVVVANITDAQAEYVDSVRKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDRE
HHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCC
KENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRII
CEEEECCCCCCHHHHCHHHHHHHHHHHCCCHHHHHEECCCCCEEECHHHHHCCCCCEEEE
TAKDAEGVEIIRHSCAHLVGHAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPDDMAAI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHH
EQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLIEDMSEDITAMGLYYHQEYVD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
MCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEAD
HHCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
KRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILD
HHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCHHHH
VSLWQKSGHWDNYQDAMFFTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGA
HHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
CHRNEPSGALHGILRVRGFTQDDGHVFCLESQIESEVTAFHQQALAVYTAFGFDDIQIKI
CCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEECCCEEEEEE
ALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQL
EECCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCEEEEEEHHHCCCEEEE
GTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPV
CEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QVVVANITDAQAEYVDSVRKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDRE
HHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCC
KENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA