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The map label for this gene is dapA2 [H]

Identifier: 78048300

GI number: 78048300

Start: 3124590

End: 3125498

Strand: Reverse

Name: dapA2 [H]

Synonym: XCV2744

Alternate gene names: 78048300

Gene position: 3125498-3124590 (Counterclockwise)

Preceding gene: 78048301

Following gene: 78048299

Centisome position: 60.36

GC content: 67.11

Gene sequence:

>909_bases
ATGAGCAATGCTGCGTTCTGGCACGGTGTGCTGCCGGCCATCACCACCCCGTTCACCGCCAACGGCGACATCGACCACGA
GTTCCTCGGCAAGCACGCCAATCAACTGGTGGATGCCGGTTGCACCGCGATCGTGCCGCTGGGCTCGTTGGGGGAGGCCG
CGACCTTGAGCGTGGAAGACAAGCTGGCGATCCTGCGCACCCTGGGCACCGCCCTGAACGGCCGCGTGCCGGTGGTGCCG
GGCATCGCCAGCCTGGCCACCGGCGAAGCGGTCGCGCTGGCCAAGGCGGCCAAGGACATCGGCTGCGGCGGCTTGATGGT
GCTGCCGCCGTACGTGTATTCCACCGACTGGCGCGAGATGGGCGCGCATGTGCGCGCGGTGATCGGCGCAACCGATCTGC
CGGTGATCCTGTACAACAACCCAGTGGCCTACAAGACCGATTTCGGCCCGGCGCAGATCGCCGAGCTGGCCGCCGAATTC
CCGAACCTGCAGGCCGTGAAGGAATCCTCCGGCGACGTGCGCCGCTTCGCTGCGCTGCAGGAATTGCTGGGCGATCGCCT
GGCGCTGCTGGTGGGCATGGACGATGCCATCGTCGAAGGCCTGAGCATGGGCGCCAAGGGCTGGATCGCCGGCCTGGTCA
ATGCGTATCCGAAGGAATCGGTGCGCCTGTTCGAACTCGCCCGCGATGGCGGTTACCCGGCGGCCAGGGAGCTTTACCAC
TGGTTCCTGCCGCTGCTGCGCCTGGATACGGTGCCCACCTTCGTGCAGCTGATCAAACTGGTGCAGGCCAAGGTCGGCAT
GGGCAGCGAGCAGGTGCGTGCGCCACGCCTGGTGGTGGCCGGCGCCGAGCGCGATGCCGCCTTGAAGGTGATCGACCATG
CCATCGCCACCGCGCCTACATTGTCTTGA

Upstream 100 bases:

>100_bases
CCGATCTTTCTACCGACGCCGGCCGCCGGCCGCCGTTGTTCCCGGTCCGCCTCGCGGCGCTGGCCGACTCGTTCACTTCC
GACTCGCAAGGGAAACATCC

Downstream 100 bases:

>100_bases
TGGCGCACTGATGCTGCCCTGGTCCGTCGTGCCTGCGGGTGAGCGCCAGGTGCCAGTTGTGCCGATTCGTAGCACGCGCC
CTGCCTGCGCGCGCCGCGAT

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSNAAFWHGVLPAITTPFTANGDIDHEFLGKHANQLVDAGCTAIVPLGSLGEAATLSVEDKLAILRTLGTALNGRVPVVP
GIASLATGEAVALAKAAKDIGCGGLMVLPPYVYSTDWREMGAHVRAVIGATDLPVILYNNPVAYKTDFGPAQIAELAAEF
PNLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAARELYH
WFLPLLRLDTVPTFVQLIKLVQAKVGMGSEQVRAPRLVVAGAERDAALKVIDHAIATAPTLS

Sequences:

>Translated_302_residues
MSNAAFWHGVLPAITTPFTANGDIDHEFLGKHANQLVDAGCTAIVPLGSLGEAATLSVEDKLAILRTLGTALNGRVPVVP
GIASLATGEAVALAKAAKDIGCGGLMVLPPYVYSTDWREMGAHVRAVIGATDLPVILYNNPVAYKTDFGPAQIAELAAEF
PNLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAARELYH
WFLPLLRLDTVPTFVQLIKLVQAKVGMGSEQVRAPRLVVAGAERDAALKVIDHAIATAPTLS
>Mature_301_residues
SNAAFWHGVLPAITTPFTANGDIDHEFLGKHANQLVDAGCTAIVPLGSLGEAATLSVEDKLAILRTLGTALNGRVPVVPG
IASLATGEAVALAKAAKDIGCGGLMVLPPYVYSTDWREMGAHVRAVIGATDLPVILYNNPVAYKTDFGPAQIAELAAEFP
NLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAARELYHW
FLPLLRLDTVPTFVQLIKLVQAKVGMGSEQVRAPRLVVAGAERDAALKVIDHAIATAPTLS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=280, Percent_Identity=23.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31543060, Length=235, Percent_Identity=24.2553191489362, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=27.8350515463918, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI87082415, Length=289, Percent_Identity=27.3356401384083, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786463, Length=263, Percent_Identity=28.5171102661597, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789620, Length=212, Percent_Identity=27.8301886792453, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31883; Mature: 31752

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAAFWHGVLPAITTPFTANGDIDHEFLGKHANQLVDAGCTAIVPLGSLGEAATLSVED
CCCCCHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECHHH
KLAILRTLGTALNGRVPVVPGIASLATGEAVALAKAAKDIGCGGLMVLPPYVYSTDWREM
HHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHH
GAHVRAVIGATDLPVILYNNPVAYKTDFGPAQIAELAAEFPNLQAVKESSGDVRRFAALQ
HHHHHHHHCCCCCCEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHH
ELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAARELYH
HHHHHHHEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
WFLPLLRLDTVPTFVQLIKLVQAKVGMGSEQVRAPRLVVAGAERDAALKVIDHAIATAPT
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCC
LS
CC
>Mature Secondary Structure 
SNAAFWHGVLPAITTPFTANGDIDHEFLGKHANQLVDAGCTAIVPLGSLGEAATLSVED
CCCCHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECHHH
KLAILRTLGTALNGRVPVVPGIASLATGEAVALAKAAKDIGCGGLMVLPPYVYSTDWREM
HHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHH
GAHVRAVIGATDLPVILYNNPVAYKTDFGPAQIAELAAEFPNLQAVKESSGDVRRFAALQ
HHHHHHHHCCCCCCEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHH
ELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAARELYH
HHHHHHHEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
WFLPLLRLDTVPTFVQLIKLVQAKVGMGSEQVRAPRLVVAGAERDAALKVIDHAIATAPT
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCC
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA