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The map label for this gene is ggt2 [H]

Identifier: 78048262

GI number: 78048262

Start: 3065621

End: 3067399

Strand: Reverse

Name: ggt2 [H]

Synonym: XCV2706

Alternate gene names: 78048262

Gene position: 3067399-3065621 (Counterclockwise)

Preceding gene: 78048263

Following gene: 78048261

Centisome position: 59.23

GC content: 67.79

Gene sequence:

>1779_bases
GTGAGCACTTTTTCCCGTCGTTTTTCTTCGCGCGGCGTGTTGCTGCTGGCCTTTGTGCTGGCGCCAGCGGCCTGGTGCGC
CGATGCCGCCAAGCCGGCGACGGCCACCACCGCAGCGGTCGCCGCGCATCCACCCGGCGCGGCGATCGCCAGCGGCCATG
CGCTGGCCACCGATGCCGGCCTGCAGATCCTGCGCGAGGGCGGGAATGCGTTCGATGCCGCGGTGGCGGTGTCGTCCACG
CTGGCGGTGGTCGAGCCGATCAGCTCAGGGCTGGGCGGCGGCGGTTTCTTCCTGTTGCACGACGCCAAGACCGGCAAGGA
CGTGATGCTGGACGCGCGCGAAACCGCGCCCGCGTCGGCCACCGAAGCGCAGTTTCTCGACAAGAAAGGCGAGCTGGACC
GCGACCGCTCGGTCAATGGCCCGTGGTCGGCGGGCATCCCGGGCTTGCCCGCAGCGCTGGTGGAGCTGGCTGCCAAACAC
GGCCGGCTGCCGCTGAAGCAGTCGCTGGCACCCTCGATCCGCATCGCGACGGAGGGTTTTCCCGTCTACGCGCGCATGGC
CAAGGGCTATGCCTCGCGGCGCGAGGTGATGGAGCGTTACCCCGGTACGCGCGAGGTGTATCTGCGCGGCGGCAAACCCA
TTGCCGAAGGCGACACCTTCAAGCAGCCGGAGCTGGCGCAGACGCTGCAGCTGCTCGGCGACAAGGGCTTCGACGGGTTT
TACAAGGGCGAGACCGCCAAGAAGTTGCTGGCCGGCGTGAAGCAGGCCGGCGGCCAGTGGAGCGCGGCCGAGCTGGCCGG
GTACCGGGTCAAGGAGCGCGCACCGATCCAGTTCGACTACCGCGGCTGGAAGATCACCACTGCGCCGCCGCCGTCGTCCG
GTGGTATTGCGCTGGCGGCGATGCTGCAGATCCTGGAGGGCTGGGACTTGAACACGCTCGATGAGGTGCATCGCACCCAT
CTGGTGGTGGAGTCGATGCGCCGCGCCTACCGCGATCGCACCTTCTTCCTGGGCGACCCGGACTTTGTGGACGTGCCGCA
GCGCGTGCTCACCAGCAAGGACTACGCGCAAGGCCTGCGTGCCACCATCAACCCGGACAAGGCCACGCCCAGCGATCTGC
TGTCGGGCAACCCCACGCCGCTGGAAGACGACGAGACCACGCACTTTTCCATCATCGATGGCGAAGGCAACCGCGTCGGT
GCCACCCAGACGGTGAACCTGCTGTACGGCTCGGGCCTGATTCCCAAGGGCACCGGCGTGCTGCTCAACAACGAGATGGA
CGACTTCGCGCTCAAGCCGGGCACTCCGAATGCGTTCGGCGTGATGGGCTACGCCGCCAACGCGCCCAAGCCGGGCAAGC
GCATGCTCAGTTCGATGACGCCCACCTTCATGGAATCGGCCGACAAGGCGATCGTGCTCGGCACCCCGGGCGGCAGCCGC
ATCATCACCATGGTGCTGCTGGGGATCCTGGGCTACGACGCCGGCCTGGATGCGCAGGCGGTCAGTGCGCTGCCGCGCTA
TCACCACCAGTGGTTGCCGGACGTGATCGACGCCGAGACCAACGCGTTTTCGGCGCAGACCGCCAAGGGCCTGCAAGCGA
TGGGGCATGCACTGAAATTGCCAGGCGACACCGCCGAAGGCGGCCGTGGCTCCAGCCATGTGTGGGGCAACCTGCAAACG
GTGGAGTGGGACAAGCGCCGCAACGTGCTCAGCGGCGGTAGCGACCCGCGTAACCCGGTGGGCAAGGCGCAAGTGCAATT
GGACGCGACGGCACGCTGA

Upstream 100 bases:

>100_bases
CGGATCCGGCCATTCCGGAAACCCATGACCAGTTGCTGGCCAAGCTGATGCAGTTGCAGCGCGATCACCCCGAACTGTAC
GAACAGGAGCCCCCCGCCCC

Downstream 100 bases:

>100_bases
GGCGTGAACCCGATTGCGTCGACGCCCGGTAGCCGGCAAGGCGGCCGGGCGTTGTTCGTTGTTTCGATCAAGCGCCATCG
ATGCAATGCGACCGTGGTTG

Product: gamma-glutamyltranspeptidase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTAAVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSST
LAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKH
GRLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDTFKQPELAQTLQLLGDKGFDGF
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNTLDEVHRTH
LVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVG
ATQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETNAFSAQTAKGLQAMGHALKLPGDTAEGGRGSSHVWGNLQT
VEWDKRRNVLSGGSDPRNPVGKAQVQLDATAR

Sequences:

>Translated_592_residues
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTAAVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSST
LAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKH
GRLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDTFKQPELAQTLQLLGDKGFDGF
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNTLDEVHRTH
LVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVG
ATQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETNAFSAQTAKGLQAMGHALKLPGDTAEGGRGSSHVWGNLQT
VEWDKRRNVLSGGSDPRNPVGKAQVQLDATAR
>Mature_591_residues
STFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTAAVAAHPPGAAIASGHALATDAGLQILREGGNAFDAAVAVSSTL
AVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASATEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHG
RLPLKQSLAPSIRIATEGFPVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDTFKQPELAQTLQLLGDKGFDGFY
KGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAAMLQILEGWDLNTLDEVHRTHL
VVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLRATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGA
TQTVNLLYGSGLIPKGTGVLLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSRI
ITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETNAFSAQTAKGLQAMGHALKLPGDTAEGGRGSSHVWGNLQTV
EWDKRRNVLSGGSDPRNPVGKAQVQLDATAR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=507, Percent_Identity=34.3195266272189, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI73915090, Length=507, Percent_Identity=34.3195266272189, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI73915096, Length=507, Percent_Identity=34.3195266272189, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI73915094, Length=507, Percent_Identity=34.3195266272189, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI113429324, Length=495, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI113429326, Length=500, Percent_Identity=32.8, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI109148539, Length=511, Percent_Identity=30.7240704500978, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI153266901, Length=508, Percent_Identity=28.3464566929134, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI153266885, Length=507, Percent_Identity=28.0078895463511, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI153266907, Length=507, Percent_Identity=26.232741617357, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI30581157, Length=195, Percent_Identity=36.9230769230769, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI30581155, Length=195, Percent_Identity=36.9230769230769, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI218505805, Length=191, Percent_Identity=34.5549738219895, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310124095, Length=193, Percent_Identity=32.1243523316062, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789856, Length=500, Percent_Identity=41.8, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI72000294, Length=490, Percent_Identity=34.4897959183673, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI212646519, Length=490, Percent_Identity=34.4897959183673, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=510, Percent_Identity=32.3529411764706, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI193208247, Length=510, Percent_Identity=32.3529411764706, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17506189, Length=514, Percent_Identity=32.1011673151751, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17542894, Length=503, Percent_Identity=29.0258449304175, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17564448, Length=391, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=542, Percent_Identity=27.6752767527675, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI161077880, Length=535, Percent_Identity=31.588785046729, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI161077878, Length=535, Percent_Identity=31.588785046729, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI45551474, Length=535, Percent_Identity=31.588785046729, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24642670, Length=535, Percent_Identity=31.588785046729, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24642666, Length=535, Percent_Identity=31.588785046729, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=31.7025440313112, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077496, Length=535, Percent_Identity=30.4672897196262, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI18859741, Length=498, Percent_Identity=26.9076305220884, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62707; Mature: 62576

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTAAVAAHPPGAAIASGHALATDAG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCHHHCCCCHHHHHH
LQILREGGNAFDAAVAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCCCCH
TEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLKQSLAPSIRIATEGF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCC
PVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDTFKQPELAQTLQLLGDKGFDGF
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCEEEECCCEEEEECCCCCCCCHHHHH
MLQILEGWDLNTLDEVHRTHLVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHCCC
ATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTGV
EECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCCE
LLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
EECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCHH
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETNAFSAQTAKGLQAMGHALKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHEEC
PGDTAEGGRGSSHVWGNLQTVEWDKRRNVLSGGSDPRNPVGKAQVQLDATAR
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
STFSRRFSSRGVLLLAFVLAPAAWCADAAKPATATTAAVAAHPPGAAIASGHALATDAG
CHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCHHHCCCCHHHHHH
LQILREGGNAFDAAVAVSSTLAVVEPISSGLGGGGFFLLHDAKTGKDVMLDARETAPASA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCCCCH
TEAQFLDKKGELDRDRSVNGPWSAGIPGLPAALVELAAKHGRLPLKQSLAPSIRIATEGF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCC
PVYARMAKGYASRREVMERYPGTREVYLRGGKPIAEGDTFKQPELAQTLQLLGDKGFDGF
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
YKGETAKKLLAGVKQAGGQWSAAELAGYRVKERAPIQFDYRGWKITTAPPPSSGGIALAA
CCCHHHHHHHHHHHHCCCCCCHHHHHCCEECCCCCEEEECCCEEEEECCCCCCCCHHHHH
MLQILEGWDLNTLDEVHRTHLVVESMRRAYRDRTFFLGDPDFVDVPQRVLTSKDYAQGLR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHCCC
ATINPDKATPSDLLSGNPTPLEDDETTHFSIIDGEGNRVGATQTVNLLYGSGLIPKGTGV
EECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCEECCCEEEEEEECCCCCCCCCCE
LLNNEMDDFALKPGTPNAFGVMGYAANAPKPGKRMLSSMTPTFMESADKAIVLGTPGGSR
EECCCCCCCEECCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEECCCCHH
IITMVLLGILGYDAGLDAQAVSALPRYHHQWLPDVIDAETNAFSAQTAKGLQAMGHALKL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHEEC
PGDTAEGGRGSSHVWGNLQTVEWDKRRNVLSGGSDPRNPVGKAQVQLDATAR
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]