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The map label for this gene is oxyR [H]

Identifier: 78047128

GI number: 78047128

Start: 1773554

End: 1774453

Strand: Reverse

Name: oxyR [H]

Synonym: XCV1572

Alternate gene names: 78047128

Gene position: 1774453-1773554 (Counterclockwise)

Preceding gene: 78047129

Following gene: 78047127

Centisome position: 34.27

GC content: 67.0

Gene sequence:

>900_bases
ATGCCCCGCCCCAGAACCACCCTTCGCCAGCTGAGCTATTTCGTCGCGCTGGCCGATACCGGCAGCTTTACCCGTGCCGC
CGAGCAGATGGGCGTCTCGCAGCCATCGTTGTCGCAGCAGATCCGCGCGTTGGAAGCGATCATCGGTGCGCCACTGTTCG
AGCGCGGCGCGCAGGCGATCCTGACCCCGCTCGGTCGCGAGCTGCTCGACCGCGCACGCAGCATCCTGCTCGATGTCACC
GATCTGGAAGAGGTCCGCGCCACCGCCGCCGATACCTTGATCGGCACCATTCGCCTTGGCGTCTCGCCCACGCTCGGCGC
CTATCTGATGCCCAGCCTGGTGGCACGTCTGCATCGCGAGCATCCGGCCCTGCGCGTGCACGTGCGCGAAGGCCTGCCAA
CCGCACTCGCCGCCGACCTGAGCAGCGGCACGCACGATCTGGTCCTCGCGCAACTGCCGGTGGCCGGCCGCGGCCTGCAC
AGCGAGCGGCTGTTTCGCGAACTGCTGCATGTGACCATGGCGGCCGATCATCCGCTGCGCACCAAGGCCTGCATCACCCC
GGCCGATCTGCGCGGTGCCAACTTGCTGACCTTGATGCCGGAATACCGATTGGCAGAACAGGTTGCCGCGATCGCCATGG
ACGTGGGCGCCAATGTCTTGCGCGATTACGAAGGCACCAGCCTGGACGCGATCCGCCAGATGGCCGGCATGGGCATGGGT
CTTGCCTTGCTCCCGGACCTGTACGTGCGCCAGGAAATCCGCGAAGGCGACGATGTGGTGGTGCGGCCGGTCAAAGGCGG
GCGCTACTATAGGGAGATCGGTCTGCTCTGGCGCCAGGGTGCCGGTCGCGCACCGGCCTTCGGTTTGATCGCCAATCTGT
TGCGCGCGGTGGCTGCATAG

Upstream 100 bases:

>100_bases
TCGCCGGACGCGCTGCCGCTGCACTCGCTAGCCGTACCTCGCCCGTCTTGTCTCACCGGCCACGCCGGCCGTGCGCTCCC
ACGCAATCCGATGTGACCCC

Downstream 100 bases:

>100_bases
GAAAATCCTATGCGGCACATAAGCGCGATGGCCTTGTTTGCGGGCCGGCAACTCGTCAATGCTTCACTGAACTCATCAAC
GGATATCGAATGGCGGCCAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MPRPRTTLRQLSYFVALADTGSFTRAAEQMGVSQPSLSQQIRALEAIIGAPLFERGAQAILTPLGRELLDRARSILLDVT
DLEEVRATAADTLIGTIRLGVSPTLGAYLMPSLVARLHREHPALRVHVREGLPTALAADLSSGTHDLVLAQLPVAGRGLH
SERLFRELLHVTMAADHPLRTKACITPADLRGANLLTLMPEYRLAEQVAAIAMDVGANVLRDYEGTSLDAIRQMAGMGMG
LALLPDLYVRQEIREGDDVVVRPVKGGRYYREIGLLWRQGAGRAPAFGLIANLLRAVAA

Sequences:

>Translated_299_residues
MPRPRTTLRQLSYFVALADTGSFTRAAEQMGVSQPSLSQQIRALEAIIGAPLFERGAQAILTPLGRELLDRARSILLDVT
DLEEVRATAADTLIGTIRLGVSPTLGAYLMPSLVARLHREHPALRVHVREGLPTALAADLSSGTHDLVLAQLPVAGRGLH
SERLFRELLHVTMAADHPLRTKACITPADLRGANLLTLMPEYRLAEQVAAIAMDVGANVLRDYEGTSLDAIRQMAGMGMG
LALLPDLYVRQEIREGDDVVVRPVKGGRYYREIGLLWRQGAGRAPAFGLIANLLRAVAA
>Mature_298_residues
PRPRTTLRQLSYFVALADTGSFTRAAEQMGVSQPSLSQQIRALEAIIGAPLFERGAQAILTPLGRELLDRARSILLDVTD
LEEVRATAADTLIGTIRLGVSPTLGAYLMPSLVARLHREHPALRVHVREGLPTALAADLSSGTHDLVLAQLPVAGRGLHS
ERLFRELLHVTMAADHPLRTKACITPADLRGANLLTLMPEYRLAEQVAAIAMDVGANVLRDYEGTSLDAIRQMAGMGMGL
ALLPDLYVRQEIREGDDVVVRPVKGGRYYREIGLLWRQGAGRAPAFGLIANLLRAVAA

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=291, Percent_Identity=35.7388316151203, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788887, Length=276, Percent_Identity=30.7971014492754, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI157672245, Length=227, Percent_Identity=30.8370044052863, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=28.8389513108614, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1789639, Length=263, Percent_Identity=29.277566539924, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=28.6689419795222, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=24.0963855421687, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081904, Length=296, Percent_Identity=28.0405405405405, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=152, Percent_Identity=30.9210526315789, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790262, Length=286, Percent_Identity=27.6223776223776, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=306, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788748, Length=261, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=255, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786401, Length=263, Percent_Identity=23.574144486692, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32399; Mature: 32268

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPRTTLRQLSYFVALADTGSFTRAAEQMGVSQPSLSQQIRALEAIIGAPLFERGAQAI
CCCCHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LTPLGRELLDRARSILLDVTDLEEVRATAADTLIGTIRLGVSPTLGAYLMPSLVARLHRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
HPALRVHVREGLPTALAADLSSGTHDLVLAQLPVAGRGLHSERLFRELLHVTMAADHPLR
CCCEEEEECCCCCHHHHHHHCCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
TKACITPADLRGANLLTLMPEYRLAEQVAAIAMDVGANVLRDYEGTSLDAIRQMAGMGMG
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
LALLPDLYVRQEIREGDDVVVRPVKGGRYYREIGLLWRQGAGRAPAFGLIANLLRAVAA
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRPRTTLRQLSYFVALADTGSFTRAAEQMGVSQPSLSQQIRALEAIIGAPLFERGAQAI
CCCHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
LTPLGRELLDRARSILLDVTDLEEVRATAADTLIGTIRLGVSPTLGAYLMPSLVARLHRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
HPALRVHVREGLPTALAADLSSGTHDLVLAQLPVAGRGLHSERLFRELLHVTMAADHPLR
CCCEEEEECCCCCHHHHHHHCCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
TKACITPADLRGANLLTLMPEYRLAEQVAAIAMDVGANVLRDYEGTSLDAIRQMAGMGMG
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
LALLPDLYVRQEIREGDDVVVRPVKGGRYYREIGLLWRQGAGRAPAFGLIANLLRAVAA
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]