Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 78047030

GI number: 78047030

Start: 1656957

End: 1657715

Strand: Reverse

Name: uppS [H]

Synonym: XCV1474

Alternate gene names: 78047030

Gene position: 1657715-1656957 (Counterclockwise)

Preceding gene: 78047031

Following gene: 78047029

Centisome position: 32.01

GC content: 67.06

Gene sequence:

>759_bases
ATGCATCCAGTCCCTTCTGCTGCTGTGCCGCGCCACATCGCCATCATCATGGATGGCAATGGGCGTTGGGCGCAGCGTCG
GCGGCGTCCGCGCATGATCGGCCATCGCGCCGGCGCGCGCGCGGTCAATCGCACGATCGATTTCTGCCTGGAAAAAGGCG
TGTCGGCGCTGACCCTGTTCGCGTTTTCCAGTGAAAACTGGGGCCGTCCGCAGGATGAGGTCGACGCGCTGATGAAGCTG
TTCCTGCATGCGCTCGACCGCGAGGTCGAAGAACTGCAGCGACGTGGCGTGCAGGTGCGCTTCATCGGCGACCGCAGCCG
CTTTGCCGCACCATTGCGCGAGCGCATGGCCGGCGCCGAGCGCAGCACCGCAACGAACTCGCGGCTGGTGCTGAGCATCG
CAGCCAGCTACGGCGGCCGCCAGGACATCGCAGCGGCTGCCCGCGCATTGGCCGAAGACGTCGCTGCCGGCCGCCTGCAG
CCAGAGCAGATCGACGAAGCGCTGCTGTCCAGCCGGGTCGCCCTGGCCGACCTGCCCGCGCCGGACCTGTTCATCCGCAC
CGGTGGCGACACCCGCATCAGCAATTTCCTGTTGTGGCAGCTGGCTTACACCGAGCTGTGGTTCACCGAAACCCTGTGGC
CGGAGTTCGATGCCGGCGTGCTGCAGCAAGCGCTGGACGACTTTGCCGGGCGTGAACGCCGCTTCGGCCTGACCAGCGCA
CAGATCGCCGACAAGGCGACGGAGAGCTCCTCCGCATGA

Upstream 100 bases:

>100_bases
ATATCCAGAAGCTCACCGACAAGGCCATCAAGGACGTGGATGAGGTCGTCAAGGGCAAGGAACAGGAATTGATGACGGTC
TGATCGTGGCATCGCCTGCC

Downstream 100 bases:

>100_bases
CCAAGACTCGCGTGATTGCCGCGCTGATCATGGCGCCGCTCGCGATTTGCGCGATCGTGCTGCTGCCCACCCAATGGCTG
GCAGCGCTGGCGGCGGTCCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHPVPSAAVPRHIAIIMDGNGRWAQRRRRPRMIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVDALMKL
FLHALDREVEELQRRGVQVRFIGDRSRFAAPLRERMAGAERSTATNSRLVLSIAASYGGRQDIAAAARALAEDVAAGRLQ
PEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDFAGRERRFGLTSA
QIADKATESSSA

Sequences:

>Translated_252_residues
MHPVPSAAVPRHIAIIMDGNGRWAQRRRRPRMIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVDALMKL
FLHALDREVEELQRRGVQVRFIGDRSRFAAPLRERMAGAERSTATNSRLVLSIAASYGGRQDIAAAARALAEDVAAGRLQ
PEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDFAGRERRFGLTSA
QIADKATESSSA
>Mature_252_residues
MHPVPSAAVPRHIAIIMDGNGRWAQRRRRPRMIGHRAGARAVNRTIDFCLEKGVSALTLFAFSSENWGRPQDEVDALMKL
FLHALDREVEELQRRGVQVRFIGDRSRFAAPLRERMAGAERSTATNSRLVLSIAASYGGRQDIAAAARALAEDVAAGRLQ
PEQIDEALLSSRVALADLPAPDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDFAGRERRFGLTSA
QIADKATESSSA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=248, Percent_Identity=35.8870967741936, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI45580738, Length=255, Percent_Identity=35.6862745098039, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=57.0175438596491, Blast_Score=269, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71993029, Length=252, Percent_Identity=31.3492063492063, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=36.5740740740741, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=32.4200913242009, Blast_Score=119, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18857969, Length=256, Percent_Identity=35.15625, Blast_Score=141, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27944; Mature: 27944

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVPSAAVPRHIAIIMDGNGRWAQRRRRPRMIGHRAGARAVNRTIDFCLEKGVSALTLF
CCCCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AFSSENWGRPQDEVDALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRERMAGAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCC
RSTATNSRLVLSIAASYGGRQDIAAAARALAEDVAAGRLQPEQIDEALLSSRVALADLPA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCC
PDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDFAGRERRFGLTSA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCHH
QIADKATESSSA
HHHHHHHCCCCC
>Mature Secondary Structure
MHPVPSAAVPRHIAIIMDGNGRWAQRRRRPRMIGHRAGARAVNRTIDFCLEKGVSALTLF
CCCCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AFSSENWGRPQDEVDALMKLFLHALDREVEELQRRGVQVRFIGDRSRFAAPLRERMAGAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCC
RSTATNSRLVLSIAASYGGRQDIAAAARALAEDVAAGRLQPEQIDEALLSSRVALADLPA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCC
PDLFIRTGGDTRISNFLLWQLAYTELWFTETLWPEFDAGVLQQALDDFAGRERRFGLTSA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCHH
QIADKATESSSA
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]