Click here to switch to the map view.

The map label for this gene is hgdC [H]

Identifier: 78045224

GI number: 78045224

Start: 1054611

End: 1056263

Strand: Direct

Name: hgdC [H]

Synonym: CHY_1185

Alternate gene names: 78045224

Gene position: 1054611-1056263 (Clockwise)

Preceding gene: 78043095

Following gene: 78042698

Centisome position: 43.91

GC content: 34.72

Gene sequence:

>1653_bases
ATGCCCGTAGGGGGTGAAAACTTGGTAGGTTACGTTTGTAAATATACTCCGGTGGAAATTATCGAAGCCTTTGGAGAAAA
ACCGGTAAGGATTGAATCAGGATGTAAGTCTTATGAACGTGCCGAAGCCCTGCTTCATACAAATACGTGCAGTTTCGTGA
AAGGAGTCTTGGAAAATATTATTGAAAATAATATTGAAGAAGTGATTTTAACCAGCTGTTGTGACAGTATAAAAAGACTT
TATGATGTTTTAAAAGAAAGATTAAAATTTATTTATATTCTGGACCTCCCCAGAAAAAAAGATACTTTTGCGGTAGATGT
TTTTTATAAGGAAATTATTAAATTTATAGATGCGTATAAAGCATTTAAAAATAAAGGCTTTGCTATAGAAAATTTCTTGA
AAATTTTAGAAGATAAATCATCCTTCAGAAAGATGCAAGAACCATCTGAAAGTATTGCGATTTTAGGTGCAAGACTCAAA
GATGATGTTGTAGAAAAAATTAAAAATTCCTGCTCAGTAAATATTATAAATTTTACATGTACAGGTGAAGACAGAATATT
CAATATTGAATCAGAAGATAATTTATTAAAAGGCTATGCGGCGTCGCTTCTTAATTTAACGCCCTGCATGAGAATGGCGG
AAGATCGGAGTAAGTTCTTCAATAAAGACTTCAAGGGTATAATTTACAACACTATAAAGTTCTGTGATTATTATTCTTAT
GAGTATGCTGAAATGAAAAGTCAGTTTAATATTCCTTTTTTAAAAATTGAAACTGACTATACTGATTCTAACAGTGGACA
GATTTTAACAAGGATAGCTGCTTTTTTTGAAGCAACTGACATCAAAAAAATGGAACAAAAAAAAGCCAAAAAAGGATATT
TTGCAGGAATTGACAGTGGTTCTACTTCTACAAATGTCGTGATTATTGATGAAAATAAAAATATAATATCATATTCTATT
ATACCAACGGGGCCTAAGGCGTTAGAGAGTGCCTTTAAAGCTTTTGAAATAGCATTAAACAATGCAGGAATTAAAGAAAA
GGATATAACATCAATAGTAGCTACAGGATATGGAAGAGTAAGCATCCCCTTTGCAGATAAAATGGTCACCGAAATTACCT
GTCACGGTAAAGGGGCATTTTTTATAGACAACAGGGTGAGGACCGTTATCGATATAGGGGGACAGGATAGCAAAGTAATA
AGGCTTGATGAGAGCGGCAATGTTATTGATTTTGTAATGAATGATAAATGCTCCGCCGGGACAGGCCGGTTTTTAGAAGT
GATGTCAAGGACTTTAGGTATTTCAATAAATGAAATGGCCAAAGTACATGCGGAAGTAAAAGAAAATATCACAATTACCA
GTATGTGTACAGTATTTGCGGAATCGGAAGTAATATCTCTTATTGCTCAAAATAAAGACCAAAGGGATATAATCCATGCT
CTTAACAAATCTGTTGCTTCAAAAGCAGTTTCCCTGGTTGACCGAATAGGAAGAAAGGGCAAATATATGATGACTGGTGG
CGTTGCTAAAAATCAGGGAGTAGTTTCGGCAATCGAAAGCAAACTTGGGGAAAAACTTGTAATCCCCGCTGAACCTCAGA
TTATTGGTGCGCTTGGAGCAGCACTAATTGCCTTTGAAGGTACAAACGGATAA

Upstream 100 bases:

>100_bases
TCCCATTTCTTTATTTAGATGGCGACTGTGTAGATAAAAGAAATAACCAGGTGGGGCAGAACAGGACAAGGCTGGAAGCT
TTTCTTGAAATGCTTTAGTA

Downstream 100 bases:

>100_bases
CCTAAATAATTTTTGTATACACACATTTTATCCGTAAAGAAGGGCATAGAGAAAATGTAAGATTCCAGCGACCTTTTAAT
CTTTTCGACGCCTTCACTGA

Product: putative CoA dehydratase subunit/(R)-2-hydroxyglutaryl-CoA dehydratase activator

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MPVGGENLVGYVCKYTPVEIIEAFGEKPVRIESGCKSYERAEALLHTNTCSFVKGVLENIIENNIEEVILTSCCDSIKRL
YDVLKERLKFIYILDLPRKKDTFAVDVFYKEIIKFIDAYKAFKNKGFAIENFLKILEDKSSFRKMQEPSESIAILGARLK
DDVVEKIKNSCSVNIINFTCTGEDRIFNIESEDNLLKGYAASLLNLTPCMRMAEDRSKFFNKDFKGIIYNTIKFCDYYSY
EYAEMKSQFNIPFLKIETDYTDSNSGQILTRIAAFFEATDIKKMEQKKAKKGYFAGIDSGSTSTNVVIIDENKNIISYSI
IPTGPKALESAFKAFEIALNNAGIKEKDITSIVATGYGRVSIPFADKMVTEITCHGKGAFFIDNRVRTVIDIGGQDSKVI
RLDESGNVIDFVMNDKCSAGTGRFLEVMSRTLGISINEMAKVHAEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHA
LNKSVASKAVSLVDRIGRKGKYMMTGGVAKNQGVVSAIESKLGEKLVIPAEPQIIGALGAALIAFEGTNG

Sequences:

>Translated_550_residues
MPVGGENLVGYVCKYTPVEIIEAFGEKPVRIESGCKSYERAEALLHTNTCSFVKGVLENIIENNIEEVILTSCCDSIKRL
YDVLKERLKFIYILDLPRKKDTFAVDVFYKEIIKFIDAYKAFKNKGFAIENFLKILEDKSSFRKMQEPSESIAILGARLK
DDVVEKIKNSCSVNIINFTCTGEDRIFNIESEDNLLKGYAASLLNLTPCMRMAEDRSKFFNKDFKGIIYNTIKFCDYYSY
EYAEMKSQFNIPFLKIETDYTDSNSGQILTRIAAFFEATDIKKMEQKKAKKGYFAGIDSGSTSTNVVIIDENKNIISYSI
IPTGPKALESAFKAFEIALNNAGIKEKDITSIVATGYGRVSIPFADKMVTEITCHGKGAFFIDNRVRTVIDIGGQDSKVI
RLDESGNVIDFVMNDKCSAGTGRFLEVMSRTLGISINEMAKVHAEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHA
LNKSVASKAVSLVDRIGRKGKYMMTGGVAKNQGVVSAIESKLGEKLVIPAEPQIIGALGAALIAFEGTNG
>Mature_549_residues
PVGGENLVGYVCKYTPVEIIEAFGEKPVRIESGCKSYERAEALLHTNTCSFVKGVLENIIENNIEEVILTSCCDSIKRLY
DVLKERLKFIYILDLPRKKDTFAVDVFYKEIIKFIDAYKAFKNKGFAIENFLKILEDKSSFRKMQEPSESIAILGARLKD
DVVEKIKNSCSVNIINFTCTGEDRIFNIESEDNLLKGYAASLLNLTPCMRMAEDRSKFFNKDFKGIIYNTIKFCDYYSYE
YAEMKSQFNIPFLKIETDYTDSNSGQILTRIAAFFEATDIKKMEQKKAKKGYFAGIDSGSTSTNVVIIDENKNIISYSII
PTGPKALESAFKAFEIALNNAGIKEKDITSIVATGYGRVSIPFADKMVTEITCHGKGAFFIDNRVRTVIDIGGQDSKVIR
LDESGNVIDFVMNDKCSAGTGRFLEVMSRTLGISINEMAKVHAEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHAL
NKSVASKAVSLVDRIGRKGKYMMTGGVAKNQGVVSAIESKLGEKLVIPAEPQIIGALGAALIAFEGTNG

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=254, Percent_Identity=42.9133858267717, Blast_Score=188, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 61083; Mature: 60952

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVGGENLVGYVCKYTPVEIIEAFGEKPVRIESGCKSYERAEALLHTNTCSFVKGVLENI
CCCCCCCHHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IENNIEEVILTSCCDSIKRLYDVLKERLKFIYILDLPRKKDTFAVDVFYKEIIKFIDAYK
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHH
AFKNKGFAIENFLKILEDKSSFRKMQEPSESIAILGARLKDDVVEKIKNSCSVNIINFTC
HHHCCCCCHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
TGEDRIFNIESEDNLLKGYAASLLNLTPCMRMAEDRSKFFNKDFKGIIYNTIKFCDYYSY
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCH
EYAEMKSQFNIPFLKIETDYTDSNSGQILTRIAAFFEATDIKKMEQKKAKKGYFAGIDSG
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
STSTNVVIIDENKNIISYSIIPTGPKALESAFKAFEIALNNAGIKEKDITSIVATGYGRV
CCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEE
SIPFADKMVTEITCHGKGAFFIDNRVRTVIDIGGQDSKVIRLDESGNVIDFVMNDKCSAG
ECCHHHHHHHEEEECCCCEEEECCCCEEEEEECCCCCEEEEECCCCCEEEEEECCCCCCC
TGRFLEVMSRTLGISINEMAKVHAEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHA
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LNKSVASKAVSLVDRIGRKGKYMMTGGVAKNQGVVSAIESKLGEKLVIPAEPQIIGALGA
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHH
ALIAFEGTNG
EEEEEECCCC
>Mature Secondary Structure 
PVGGENLVGYVCKYTPVEIIEAFGEKPVRIESGCKSYERAEALLHTNTCSFVKGVLENI
CCCCCCHHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IENNIEEVILTSCCDSIKRLYDVLKERLKFIYILDLPRKKDTFAVDVFYKEIIKFIDAYK
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHH
AFKNKGFAIENFLKILEDKSSFRKMQEPSESIAILGARLKDDVVEKIKNSCSVNIINFTC
HHHCCCCCHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEE
TGEDRIFNIESEDNLLKGYAASLLNLTPCMRMAEDRSKFFNKDFKGIIYNTIKFCDYYSY
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCH
EYAEMKSQFNIPFLKIETDYTDSNSGQILTRIAAFFEATDIKKMEQKKAKKGYFAGIDSG
HHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
STSTNVVIIDENKNIISYSIIPTGPKALESAFKAFEIALNNAGIKEKDITSIVATGYGRV
CCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEE
SIPFADKMVTEITCHGKGAFFIDNRVRTVIDIGGQDSKVIRLDESGNVIDFVMNDKCSAG
ECCHHHHHHHEEEECCCCEEEECCCCEEEEEECCCCCEEEEECCCCCEEEEEECCCCCCC
TGRFLEVMSRTLGISINEMAKVHAEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHA
CHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LNKSVASKAVSLVDRIGRKGKYMMTGGVAKNQGVVSAIESKLGEKLVIPAEPQIIGALGA
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHH
ALIAFEGTNG
EEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]