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The map label for this gene is purL

Identifier: 78044209

GI number: 78044209

Start: 949154

End: 951340

Strand: Direct

Name: purL

Synonym: CHY_1074

Alternate gene names: 78044209

Gene position: 949154-951340 (Clockwise)

Preceding gene: 78043830

Following gene: 78043394

Centisome position: 39.52

GC content: 51.3

Gene sequence:

>2187_bases
GTGGCTAAGTGGCGGGAGATGGGCTTAACCGACGAAGAATACCGGCGAATTGTCGAGTATCTGGGCCGCGAACCAAATGA
AGTGGAACTGGGCATGTGTGCGGTGATGTGGTCGGAGCACTGCAGCTATAAAAGTTCCAAGATTCATTTAAAAAAGCTTC
CCACCAGGGGTCCGGCGGTGGTGCAGGGGCCCGGGGAAAATGCCGGAGTGGTCGATATCGGAGACGGACTGGGAATTGCC
TTTAAAATTGAAAGCCATAACCACCCGTCAGCCATCGAGCCCTACCAGGGAGCGGCAACGGGAGTCGGGGGGATAATCCG
GGACATCTTTGCCATGGGAGCGCGGCCGATAGCCCTTTTGGATTCCCTTCGCTTTGGCAAACTTCACTCACCCAGGGTTC
GCCACCTTTTTACCGGCGTGGTGGCCGGGATTGCGGGTTACGGTAACTGCATCGGGATTCCTACGGTGGCGGGGGATGTT
TATTTTCAGGAATCGTATGAAGAAAATCCTCTGGTAAATGCGATGTGTGTGGGCATCGTGGAGCTTTCCAAACTGAAAAA
AGGTGTAGCCACGGGGGTAGGCAATCCTGTTCTTTTGGTAGGAGCGACTACCGGGCGCGACGGGATTCACGGAGCCACCT
TTGCTTCCGAAGAGCTGTCCCAGGACGGGGAGGATAAACGGCCTTCGGTGCAGGTGGGAGACCCCTTTATGGAAAAGCTT
TTACTGGAAGCATGTCTGGAAGCTCTGGAATACGGTCACATCGTTGGCATGCAGGATCTGGGCGCCGCCGGACTTACCAG
TTCTTCATCGGAAATGGCCGCCCGGGGGAAATCGGGTATCCGGCTCTACCTGGACAGGGTGCCCCTCCGGGAAGAGGGGA
TGACCCCTTACGAAATTATGCTTTCCGAATCCCAGGAACGGATGCTTTTAGTGGTGGAAAAAGGGTATGAGGATGAAATC
ATCAAAATCTTTAAAAAGTGGGATTTAAATGCGGTGGTGGTGGGAGAAATTACCGATGGCGAGGAAATCGAGGTATTTTT
TGACGGGGAATGCGTTGCAAAACTTCCCTACCGCTTGCTAACCGAGGAGGCTCCCGTTTACGACCGGCCTTACCGGATTC
CGGAGATTAAAAACCTGCAAAGCATAAACCCGGCTGGGGTGGATTGCGGAGAGGCTCTGCGCCGGCTTTTACAAAGCCCC
AATATTGCCAGGAAAAGTTATGTGTACGAACAGTACGACCACCAGGTAGGGGTTAATACGGTAGTGAAACCCGGTTACTC
CGATGCCGCAGTTTTAAGAATCAAGGGTACGAAAAAGGGCATTGCCGTAAAAACCGACGGCAACGGCCGCTATGTTTACC
ATAATCCCCGGGAAGGGGCCAAACGGGCGGTACTGGAGACGGCTTTAAATTTGGCGGTTACCGGGGCAAAACCTCTGGGT
CTTACCAACTGCTTGAACTTTGGCAACCCGGAAAAGCCGGAAATTATGGGGCAGTTTGTGGAAGTAATTGCGGGGATGAA
GGAAGCGTGTGAAATTTTAAATATTCCCGTAACCGGCGGCAACGTTAGCTTTTACAACGAAACCGGTGAAAAAGCTATTT
ACCCTACACCGGTTATCGGGATGGTGGGTTTAATTGACGATTTGGAAACGGGACTTATTCCCATGGCTTTTCAGACCGAG
GGAGATTTAATTTACCTCCTGGGTGAACCCACCGGGGAGCTCGGGCAAAGCGAGTTTTTAAAGGAGTTTTTTGGGGACGT
TCTGGTTCCGGTACCACCGGTGGACCTTCAGGAAGGGAGAAGGATAATCGAGCTTTTACCCTTGTTAAAAAAGCAAGGAC
TCATTAACTCTGCTCATGATGTTAGCGATGGCGGTTTGGCGGTTTCCCTTTGTGAGGCAGCCTTTGCCGGGGAGCTGGGG
GTAAACATCGATTTTACCACTTCCCTTCTGCCGCAGGAGTTTCTTTTTTCGGAAAAAGTTGGCCTGGTAATAGTATCGGT
ATCTCCGGAAAAAGAAGAGGAGTTTATAAAGTCAGTAAAAAATGCCGGGGTTTTTGTTTTAAAGCTTGGCCGGGTGAACG
GGAAGGATGAGATAGAAATTTGCCTAAACGGTCAGAGGGTCATCCAAGAAAAGCTATCGGAGTTAAAAGCCTTGTATGAG
GGGGGCCTAAGTTGGGCTTTGAAATAA

Upstream 100 bases:

>100_bases
ATGCCCCATCCGGAGCGCTGCTCGGAGAATATCCTGGGAGGAGAGGATGGCAGGGTAATCTGGGAATCGATTATCGCGTA
CTTGGAAAGGGGGGCTAACC

Downstream 100 bases:

>100_bases
GAGAAGAGTGCGGGGTGTTTGGAATTTATGCCCCGGGGCATGATGTGGCCCGGCTTACCTACTGGGGACTTTTTGCCCTG
CAGCACCGGGGGCAGGAAAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MAKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAVVQGPGENAGVVDIGDGLGIA
FKIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALLDSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDV
YFQESYEENPLVNAMCVGIVELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKL
LLEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIMLSESQERMLLVVEKGYEDEI
IKIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLLTEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSP
NIARKSYVYEQYDHQVGVNTVVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLG
LTNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIGMVGLIDDLETGLIPMAFQTE
GDLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGRRIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELG
VNIDFTTSLLPQEFLFSEKVGLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYE
GGLSWALK

Sequences:

>Translated_728_residues
MAKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAVVQGPGENAGVVDIGDGLGIA
FKIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALLDSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDV
YFQESYEENPLVNAMCVGIVELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKL
LLEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIMLSESQERMLLVVEKGYEDEI
IKIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLLTEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSP
NIARKSYVYEQYDHQVGVNTVVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLG
LTNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIGMVGLIDDLETGLIPMAFQTE
GDLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGRRIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELG
VNIDFTTSLLPQEFLFSEKVGLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYE
GGLSWALK
>Mature_727_residues
AKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAVVQGPGENAGVVDIGDGLGIAF
KIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALLDSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDVY
FQESYEENPLVNAMCVGIVELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKLL
LEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIMLSESQERMLLVVEKGYEDEII
KIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLLTEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSPN
IARKSYVYEQYDHQVGVNTVVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLGL
TNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIGMVGLIDDLETGLIPMAFQTEG
DLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGRRIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELGV
NIDFTTSLLPQEFLFSEKVGLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYEG
GLSWALK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=719, Percent_Identity=26.5646731571627, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI48994899, Length=808, Percent_Identity=25.7425742574257, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321498, Length=777, Percent_Identity=24.8391248391248, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582111, Length=648, Percent_Identity=24.537037037037, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24582109, Length=648, Percent_Identity=24.537037037037, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17137292, Length=648, Percent_Identity=24.537037037037, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_CARHZ (Q3AD64)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359920.1
- ProteinModelPortal:   Q3AD64
- SMR:   Q3AD64
- STRING:   Q3AD64
- GeneID:   3727326
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1074
- NMPDR:   fig|246194.3.peg.874
- TIGR:   CHY_1074
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- BioCyc:   CHYD246194:CHY_1074-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79120; Mature: 78989

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAV
CCCCHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEE
VQGPGENAGVVDIGDGLGIAFKIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALL
EECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
DSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDVYFQESYEENPLVNAMCVGIV
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCCHHHHHHHHH
ELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKL
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCHHHHHH
LLEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIM
HHHHHHHHHHCCCEECHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCEEE
LSESQERMLLVVEKGYEDEIIKIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLL
ECCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHCCHHHH
TEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSPNIARKSYVYEQYDHQVGVNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
VVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLG
EECCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHEEECCCCCC
LTNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIG
HHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHEEECEECCCCEEEECCCCCCCCCCCCHHH
MVGLIDDLETGLIPMAFQTEGDLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGR
HHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCEECCCCCCCHHHHH
RIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELGVNIDFTTSLLPQEFLFSEKV
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHCCHHHHHCCCC
GLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYE
CEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
GGLSWALK
CCCCEECC
>Mature Secondary Structure 
AKWREMGLTDEEYRRIVEYLGREPNEVELGMCAVMWSEHCSYKSSKIHLKKLPTRGPAV
CCCHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEE
VQGPGENAGVVDIGDGLGIAFKIESHNHPSAIEPYQGAATGVGGIIRDIFAMGARPIALL
EECCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHH
DSLRFGKLHSPRVRHLFTGVVAGIAGYGNCIGIPTVAGDVYFQESYEENPLVNAMCVGIV
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCCHHHHHHHHH
ELSKLKKGVATGVGNPVLLVGATTGRDGIHGATFASEELSQDGEDKRPSVQVGDPFMEKL
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCHHHHHH
LLEACLEALEYGHIVGMQDLGAAGLTSSSSEMAARGKSGIRLYLDRVPLREEGMTPYEIM
HHHHHHHHHHCCCEECHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCEEE
LSESQERMLLVVEKGYEDEIIKIFKKWDLNAVVVGEITDGEEIEVFFDGECVAKLPYRLL
ECCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHCCHHHH
TEEAPVYDRPYRIPEIKNLQSINPAGVDCGEALRRLLQSPNIARKSYVYEQYDHQVGVNT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
VVKPGYSDAAVLRIKGTKKGIAVKTDGNGRYVYHNPREGAKRAVLETALNLAVTGAKPLG
EECCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHEEECCCCCC
LTNCLNFGNPEKPEIMGQFVEVIAGMKEACEILNIPVTGGNVSFYNETGEKAIYPTPVIG
HHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHEEECEECCCCEEEECCCCCCCCCCCCHHH
MVGLIDDLETGLIPMAFQTEGDLIYLLGEPTGELGQSEFLKEFFGDVLVPVPPVDLQEGR
HHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCEECCCCCCCHHHHH
RIIELLPLLKKQGLINSAHDVSDGGLAVSLCEAAFAGELGVNIDFTTSLLPQEFLFSEKV
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHCCHHHHHCCCC
GLVIVSVSPEKEEEFIKSVKNAGVFVLKLGRVNGKDEIEICLNGQRVIQEKLSELKALYE
CEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
GGLSWALK
CCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA