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The map label for this gene is purC [H]

Identifier: 78043284

GI number: 78043284

Start: 947489

End: 948199

Strand: Direct

Name: purC [H]

Synonym: CHY_1071

Alternate gene names: 78043284

Gene position: 947489-948199 (Clockwise)

Preceding gene: 78043887

Following gene: 78042704

Centisome position: 39.45

GC content: 41.21

Gene sequence:

>711_bases
ATGGAGAAAAAGTTTCTTTATGAAGGTAAGGCCAAAATTGTTTATGCCACCGAAAATCCCGATGAAGTGGTAGTGTACTA
CAAAGATGCGGCTACCGCCTTTGACGGTAAGAAAAAAGGAGAGATAGAAAATAAGGGCTACTTAAATGCTCAAATTTCCG
CTTATATTTTTAAGTATTTAGAAAAGCAGGGTATTAAAACCCATTTTCTTGAATTAGTTGGGGAGCGGGAACAGCGGGTC
AAAAGGCTTTCCATTATTCCGGTGGAAGTGGTCGTTCGCAATATTGCTGCGGGCTCCCTTTCCAAACGGCTGGGGCTTCC
GGAAGGGACTGATTTACCTTTTCCGGTGGTGGAGCTTTACTACAAAAACGATGAATTAGGAGACCCGATGATCAACCATT
ATCACGTGCAGGCGTTAAATCTGGCTACCCCGGAGGAAATAAAATATATGGAAGATACCGCTTTAAAGGTCAATTCTTTA
TTAAAGGAATTTTTTGACTCGCTTAATATTTTGTTAGTTGATTTTAAGCTGGAATTTGGAAGGTTTAAAAAGGAAATTCT
TTTAGGTGACGAAATATCGCCGGATACGTGCCGGTTCTGGGATAAAGATACCCGGGAAAAGCTCGATAAAGACCGGTTTA
GAAGGGATTTAGGGGGAGTAACCGAAGCCTATGCGGAAATTTTAAAGCGAATTAAGGAGAAAGCGGAATAG

Upstream 100 bases:

>100_bases
TTAACACTCGAAGAGATCGCCGAGTTATTTGATTATAATTACCACTTAAAATACGTGGATGAAATCTTTAAAAGATTTGG
TTTATAGGGGAGGTATGAAA

Downstream 100 bases:

>100_bases
GAGGGAAATCATGGCGATAGCCCGTGTAATCGTGGAATTAAAGCCCGGGGTTTTGGACCCTCAGGGGGAAGCGATTAAAA
ATTCCTTACATGCTCTCGGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MEKKFLYEGKAKIVYATENPDEVVVYYKDAATAFDGKKKGEIENKGYLNAQISAYIFKYLEKQGIKTHFLELVGEREQRV
KRLSIIPVEVVVRNIAAGSLSKRLGLPEGTDLPFPVVELYYKNDELGDPMINHYHVQALNLATPEEIKYMEDTALKVNSL
LKEFFDSLNILLVDFKLEFGRFKKEILLGDEISPDTCRFWDKDTREKLDKDRFRRDLGGVTEAYAEILKRIKEKAE

Sequences:

>Translated_236_residues
MEKKFLYEGKAKIVYATENPDEVVVYYKDAATAFDGKKKGEIENKGYLNAQISAYIFKYLEKQGIKTHFLELVGEREQRV
KRLSIIPVEVVVRNIAAGSLSKRLGLPEGTDLPFPVVELYYKNDELGDPMINHYHVQALNLATPEEIKYMEDTALKVNSL
LKEFFDSLNILLVDFKLEFGRFKKEILLGDEISPDTCRFWDKDTREKLDKDRFRRDLGGVTEAYAEILKRIKEKAE
>Mature_236_residues
MEKKFLYEGKAKIVYATENPDEVVVYYKDAATAFDGKKKGEIENKGYLNAQISAYIFKYLEKQGIKTHFLELVGEREQRV
KRLSIIPVEVVVRNIAAGSLSKRLGLPEGTDLPFPVVELYYKNDELGDPMINHYHVQALNLATPEEIKYMEDTALKVNSL
LKEFFDSLNILLVDFKLEFGRFKKEILLGDEISPDTCRFWDKDTREKLDKDRFRRDLGGVTEAYAEILKRIKEKAE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=237, Percent_Identity=33.7552742616034, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI5453539, Length=237, Percent_Identity=33.7552742616034, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI119220559, Length=244, Percent_Identity=32.3770491803279, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=46.0176991150442, Blast_Score=217, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17531275, Length=243, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=31.6455696202532, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583917, Length=237, Percent_Identity=30.8016877637131, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27297; Mature: 27297

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKFLYEGKAKIVYATENPDEVVVYYKDAATAFDGKKKGEIENKGYLNAQISAYIFKYL
CCCCEEECCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EKQGIKTHFLELVGEREQRVKRLSIIPVEVVVRNIAAGSLSKRLGLPEGTDLPFPVVELY
HHCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEE
YKNDELGDPMINHYHVQALNLATPEEIKYMEDTALKVNSLLKEFFDSLNILLVDFKLEFG
ECCCCCCCCCHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHH
RFKKEILLGDEISPDTCRFWDKDTREKLDKDRFRRDLGGVTEAYAEILKRIKEKAE
HHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKKFLYEGKAKIVYATENPDEVVVYYKDAATAFDGKKKGEIENKGYLNAQISAYIFKYL
CCCCEEECCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EKQGIKTHFLELVGEREQRVKRLSIIPVEVVVRNIAAGSLSKRLGLPEGTDLPFPVVELY
HHCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEE
YKNDELGDPMINHYHVQALNLATPEEIKYMEDTALKVNSLLKEFFDSLNILLVDFKLEFG
ECCCCCCCCCHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHH
RFKKEILLGDEISPDTCRFWDKDTREKLDKDRFRRDLGGVTEAYAEILKRIKEKAE
HHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA