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The map label for this gene is icd [H]

Identifier: 78042663

GI number: 78042663

Start: 983029

End: 984027

Strand: Direct

Name: icd [H]

Synonym: CHY_1107

Alternate gene names: 78042663

Gene position: 983029-984027 (Clockwise)

Preceding gene: 78043571

Following gene: 78044990

Centisome position: 40.93

GC content: 47.35

Gene sequence:

>999_bases
ATGGCGCATAGAGTTACATTGATTCCCGGAGACGGAATTGGTCCAGAAATTGTTGAAGCAGCCCGGCGGGTAATTGATGC
CAGCGGAGCGAATATTGAATGGGAAGTGGTGGAAGCCGGAGAAAAGGTAATGGCCGAGTACGGTACTCCGTTGCCCGAGT
ATGTTTTGGAATCTATCAAAAAAAATAAAGTTGCTTTAAAAGGCCCGATGACCACACCTATCGGCACGGGATTTCGCAGC
GTTAATGTTGCCTTAAGAAAAGCCCTGGATTTATATGCCAATGTCCGGCCGGCAAAATCTTTACCGGGTGTGGTTACCCG
TTATGAAAATATTGATTTAATTACGGTCCGGGAAAATACCGAAGACTTATATGCCGGAGTTGAGCATATGGTAGGTGATG
ATGCGGCGGAAAGCATCAAAATTATTACCCGGAAAGCTTCCCAAAGGATTGTCCGGTTTGCTTTCGAACTGGCCCGCAAA
GAGGGGCGAAAAAAGGTTACCGCCGTTCATAAAGCCAATATCATGAAGTATACCGATGGCTTATTTTTAGCGGTGGCCCG
GGAAGTGGCCGCGGAGTATCCCGATATTGAGTTTGAGGATATGATTGTTGACGCTATGGCCATGAAGTTGGTTCAAACTC
CGGAAAAATTTGATGTGATGGTGATGCCCAATCTTTACGGTGATATTTTGTCGGACCTCTGCGCGGGTTTGGTAGGTGGC
CTTGGAGTGGCACCGGGAGCCAATATCGGTGACGAATATGCAGTTTTTGAGCCGGTGCACGGAAGTGCCCCAAAGCATGC
CGGCCAAAACCGGGTAAACCCCCTGGCGGAGATTTTATCGGGGGTGATGATGTTAAAACACCTGGGAGAAATGGATGCTG
CCGCCAAAATCGAGCGGGCTTTAACCAAGGTTCTTCCCAATAAGGACATGGTTACCTATGATTTAGGCGGGACTGCAAAA
ACTTCAGAAATGGCCGATTATATTATAAAACATTTATAA

Upstream 100 bases:

>100_bases
TTAAGCCATTGCCGGAGGTAATGATCAAGATTTTAAATGACGGCGGGTTAATTGAACATTTTAAAAAATACGGCACATTT
AACTTTTAAGGAGGTTCATG

Downstream 100 bases:

>100_bases
AAGCCTCCAGTTTTGGAGGTTTTTATTTTTTTCACCAGCGGGAAATGCTAAAATAGAGATGAAAAACAGGAGGGGTTTGA
TGCTGGAAATTCGCTGGAAG

Product: putative isocitrate dehydrogenase, NAD-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAHRVTLIPGDGIGPEIVEAARRVIDASGANIEWEVVEAGEKVMAEYGTPLPEYVLESIKKNKVALKGPMTTPIGTGFRS
VNVALRKALDLYANVRPAKSLPGVVTRYENIDLITVRENTEDLYAGVEHMVGDDAAESIKIITRKASQRIVRFAFELARK
EGRKKVTAVHKANIMKYTDGLFLAVAREVAAEYPDIEFEDMIVDAMAMKLVQTPEKFDVMVMPNLYGDILSDLCAGLVGG
LGVAPGANIGDEYAVFEPVHGSAPKHAGQNRVNPLAEILSGVMMLKHLGEMDAAAKIERALTKVLPNKDMVTYDLGGTAK
TSEMADYIIKHL

Sequences:

>Translated_332_residues
MAHRVTLIPGDGIGPEIVEAARRVIDASGANIEWEVVEAGEKVMAEYGTPLPEYVLESIKKNKVALKGPMTTPIGTGFRS
VNVALRKALDLYANVRPAKSLPGVVTRYENIDLITVRENTEDLYAGVEHMVGDDAAESIKIITRKASQRIVRFAFELARK
EGRKKVTAVHKANIMKYTDGLFLAVAREVAAEYPDIEFEDMIVDAMAMKLVQTPEKFDVMVMPNLYGDILSDLCAGLVGG
LGVAPGANIGDEYAVFEPVHGSAPKHAGQNRVNPLAEILSGVMMLKHLGEMDAAAKIERALTKVLPNKDMVTYDLGGTAK
TSEMADYIIKHL
>Mature_331_residues
AHRVTLIPGDGIGPEIVEAARRVIDASGANIEWEVVEAGEKVMAEYGTPLPEYVLESIKKNKVALKGPMTTPIGTGFRSV
NVALRKALDLYANVRPAKSLPGVVTRYENIDLITVRENTEDLYAGVEHMVGDDAAESIKIITRKASQRIVRFAFELARKE
GRKKVTAVHKANIMKYTDGLFLAVAREVAAEYPDIEFEDMIVDAMAMKLVQTPEKFDVMVMPNLYGDILSDLCAGLVGGL
GVAPGANIGDEYAVFEPVHGSAPKHAGQNRVNPLAEILSGVMMLKHLGEMDAAAKIERALTKVLPNKDMVTYDLGGTAKT
SEMADYIIKHL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=335, Percent_Identity=51.6417910447761, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI4758582, Length=333, Percent_Identity=48.3483483483483, Blast_Score=297, Evalue=7e-81,
Organism=Homo sapiens, GI28178838, Length=311, Percent_Identity=48.5530546623794, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI28178821, Length=335, Percent_Identity=45.9701492537313, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI28178816, Length=335, Percent_Identity=45.6716417910448, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI28178819, Length=201, Percent_Identity=50.2487562189055, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=37.5321336760925, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87081683, Length=358, Percent_Identity=34.0782122905028, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1788101, Length=354, Percent_Identity=33.6158192090396, Blast_Score=184, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71986051, Length=322, Percent_Identity=52.4844720496894, Blast_Score=347, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI25144293, Length=341, Percent_Identity=46.9208211143695, Blast_Score=286, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17505779, Length=332, Percent_Identity=43.9759036144578, Blast_Score=264, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17550882, Length=334, Percent_Identity=44.311377245509, Blast_Score=260, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6324709, Length=334, Percent_Identity=48.502994011976, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324291, Length=335, Percent_Identity=45.9701492537313, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6322097, Length=348, Percent_Identity=39.6551724137931, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319830, Length=354, Percent_Identity=31.638418079096, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643270, Length=329, Percent_Identity=50.1519756838906, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24643268, Length=329, Percent_Identity=50.1519756838906, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI24661184, Length=334, Percent_Identity=47.0059880239521, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI161078635, Length=332, Percent_Identity=42.7710843373494, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161078633, Length=332, Percent_Identity=42.7710843373494, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24650122, Length=332, Percent_Identity=42.7710843373494, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI161078637, Length=332, Percent_Identity=42.7710843373494, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI161078639, Length=328, Percent_Identity=42.3780487804878, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI281362242, Length=335, Percent_Identity=45.0746268656716, Blast_Score=253, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24648872, Length=335, Percent_Identity=45.0746268656716, Blast_Score=253, Evalue=9e-68,
Organism=Drosophila melanogaster, GI20130355, Length=330, Percent_Identity=33.9393939393939, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI45550436, Length=304, Percent_Identity=24.6710526315789, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 36105; Mature: 35974

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRVTLIPGDGIGPEIVEAARRVIDASGANIEWEVVEAGEKVMAEYGTPLPEYVLESIK
CCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHH
KNKVALKGPMTTPIGTGFRSVNVALRKALDLYANVRPAKSLPGVVTRYENIDLITVRENT
HCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCC
EDLYAGVEHMVGDDAAESIKIITRKASQRIVRFAFELARKEGRKKVTAVHKANIMKYTDG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCH
LFLAVAREVAAEYPDIEFEDMIVDAMAMKLVQTPEKFDVMVMPNLYGDILSDLCAGLVGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCC
LGVAPGANIGDEYAVFEPVHGSAPKHAGQNRVNPLAEILSGVMMLKHLGEMDAAAKIERA
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LTKVLPNKDMVTYDLGGTAKTSEMADYIIKHL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AHRVTLIPGDGIGPEIVEAARRVIDASGANIEWEVVEAGEKVMAEYGTPLPEYVLESIK
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHH
KNKVALKGPMTTPIGTGFRSVNVALRKALDLYANVRPAKSLPGVVTRYENIDLITVRENT
HCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCC
EDLYAGVEHMVGDDAAESIKIITRKASQRIVRFAFELARKEGRKKVTAVHKANIMKYTDG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCH
LFLAVAREVAAEYPDIEFEDMIVDAMAMKLVQTPEKFDVMVMPNLYGDILSDLCAGLVGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCC
LGVAPGANIGDEYAVFEPVHGSAPKHAGQNRVNPLAEILSGVMMLKHLGEMDAAAKIERA
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LTKVLPNKDMVTYDLGGTAKTSEMADYIIKHL
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]