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The map label for this gene is glmS [H]

Identifier: 77461943

GI number: 77461943

Start: 6418193

End: 6420025

Strand: Reverse

Name: glmS [H]

Synonym: Pfl01_5726

Alternate gene names: 77461943

Gene position: 6420025-6418193 (Counterclockwise)

Preceding gene: 77461944

Following gene: 77461942

Centisome position: 99.71

GC content: 62.36

Gene sequence:

>1833_bases
ATGTGTGGAATTGTCGGCGCCGTTGCTGAACGTAATATCACCGCCATCCTGCTCGAAGGCCTCAAGCGTCTGGAATACCG
GGGCTATGACAGTGCAGGCGTCGCTGTCTTGACCAACGACGGAACCCTCGAGCGCACGCGCCGGGTGGGCAAGGTCAGTG
AACTGGATGCTGCGCTGGCCGAGCACCCACTGGTCGGTCGCCTCGGTATTGCCCACACCCGCTGGGCAACCCATGGTGCG
CCGAACGAACGTAACGCCCACCCGCATTTCTCCGGCGGCATCGCCGTGGTGCACAACGGCATCATCGAAAACCACGAAGC
GCTGCGCGAACAACTCAAGGCGCTGGGTTACGTGTTCACCTCGGACACCGACACCGAAGTCATTGCACACCTGCTCACCC
ACAAGCTCAAGGATCTGCACGATCTGACCGTTGCCCTCAAGGCCACCGTCAAGGAACTGCACGGTGCTTACGGTCTGGCG
GTAATCAACGCGCAGCAGCCGGATCGTCTGGTCGCTGCCCGCAGCGGCAGTCCGCTGGTGATCGGCCTGGGTCTGGGCGA
GAACTTCCTCGCCTCCGATCAATTGGCCCTGCGTCAGGTGACCGACCGCTTCATGTACCTGGAAGAGGGCGATATCGCCG
AGATTCGCCGTGACAGCGTGCAGATCTGGGACGTGAACGGCCAGGCGGTCGAGCGCCAGACCGTGCAGTACAGCGATGGC
GCCGAAGCGGCAGAAAAAGGCGAGTACCGCCACTACATGCTCAAGGAAATCCACGAGCAGCCGGTCGTGGTGCAACGTAC
CCTCGAAGGTCGCCTGAGCGAGAATCAGGTTCTGGTACAAGCGTTCGGCCCGCAGGCCGCCGAGCTGTTCGTCAAGGTGC
GCAACGTGCAGATCGTGGCGTGCGGCACCAGCTATCACGCCGGCATGGTTGCCCGTTACTGGCTCGAAGAGCTGGCCGGG
ATTCCATGCCAGGTCGAAGTCGCCAGTGAATTCCGCTACCGCAAGGTGGTGGTGCAGCCGGATACCCTGTTCGTCACCAT
CTCCCAGTCCGGCGAAACCGCCGACACCCTGGCCGCCCTGCGCAACGCGAAGGAACTGGGCTTCCTCGCCAGCCTGGCGA
TCTGCAACGTCGGCATCAGTTCGCTGGTGCGCGAGTCGGACCTGACCCTGCTGACCCAGGCCGGTCGTGAAATCGGCGTG
GCCTCGACCAAAGCCTTCACCACGCAACTGGTGGGTCTGCTGTTGCTGACGCTGTCCCTGGGCCAGGTACGTGGCACGCT
GGCCGATGGCGTTGAAGCCAGACTGGTCGAAGAATTGCGCCGTCTGCCAACCCGCCTCGGCGAAGCCCTGGCGATGGACG
GCACCGTGGAAAAGATTGCCGAGCTGTTCGCCGAGAAGAACCACACCTTGTTCCTGGGTCGTGGCGCGCAATTCCCGGTG
GCGATGGAAGGAGCCTTGAAGCTCAAGGAAATCTCTTACATCCACGCCGAAGCCTACCCGGCCGGCGAACTGAAACACGG
CCCGCTGGCGCTTGTGGATAACGACATGCCGGTGGTCACCGTCGCGCCGAACAACGAACTGCTGGAGAAGCTCAAGTCCA
ACTTGCAGGAAGTCCGTGCCCGCGGCGGCGAACTGATCGTGTTCGCCGACGAAAAAGCCGGGATGACCAACGGCGAAGGC
ACCCACGTGGTGCAGATGCCGCACATCCACGACATCCTGTCGCCGATTCTCTACACCATTCCGCTGCAACTGCTGTCGTA
CTACGTCGCTGTGCTCAAGGGCACTGACGTGGATCAGCCGCGTAACCTGGCGAAGTCGGTGACGGTGGAATAA

Upstream 100 bases:

>100_bases
CCCTAATTACCGATGATCGCCTGCCTTTAGATGCACGCGATCAGATTCAGGCTCGCGGTATCAACTTGATTTGCGCGACT
GTCAGTCAGGAGAAATAAGC

Downstream 100 bases:

>100_bases
GTTATCCACAGTTGATCACCCCATTGGTTTGCGACAACATAGTTTGTCCCGGTACATCATAGTTTGTCTCTGTACATCAT
AGTTTGTCAGAATGGCCAAC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVLTNDGTLERTRRVGKVSELDAALAEHPLVGRLGIAHTRWATHGA
PNERNAHPHFSGGIAVVHNGIIENHEALREQLKALGYVFTSDTDTEVIAHLLTHKLKDLHDLTVALKATVKELHGAYGLA
VINAQQPDRLVAARSGSPLVIGLGLGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWDVNGQAVERQTVQYSDG
AEAAEKGEYRHYMLKEIHEQPVVVQRTLEGRLSENQVLVQAFGPQAAELFVKVRNVQIVACGTSYHAGMVARYWLEELAG
IPCQVEVASEFRYRKVVVQPDTLFVTISQSGETADTLAALRNAKELGFLASLAICNVGISSLVRESDLTLLTQAGREIGV
ASTKAFTTQLVGLLLLTLSLGQVRGTLADGVEARLVEELRRLPTRLGEALAMDGTVEKIAELFAEKNHTLFLGRGAQFPV
AMEGALKLKEISYIHAEAYPAGELKHGPLALVDNDMPVVTVAPNNELLEKLKSNLQEVRARGGELIVFADEKAGMTNGEG
THVVQMPHIHDILSPILYTIPLQLLSYYVAVLKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVLTNDGTLERTRRVGKVSELDAALAEHPLVGRLGIAHTRWATHGA
PNERNAHPHFSGGIAVVHNGIIENHEALREQLKALGYVFTSDTDTEVIAHLLTHKLKDLHDLTVALKATVKELHGAYGLA
VINAQQPDRLVAARSGSPLVIGLGLGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWDVNGQAVERQTVQYSDG
AEAAEKGEYRHYMLKEIHEQPVVVQRTLEGRLSENQVLVQAFGPQAAELFVKVRNVQIVACGTSYHAGMVARYWLEELAG
IPCQVEVASEFRYRKVVVQPDTLFVTISQSGETADTLAALRNAKELGFLASLAICNVGISSLVRESDLTLLTQAGREIGV
ASTKAFTTQLVGLLLLTLSLGQVRGTLADGVEARLVEELRRLPTRLGEALAMDGTVEKIAELFAEKNHTLFLGRGAQFPV
AMEGALKLKEISYIHAEAYPAGELKHGPLALVDNDMPVVTVAPNNELLEKLKSNLQEVRARGGELIVFADEKAGMTNGEG
THVVQMPHIHDILSPILYTIPLQLLSYYVAVLKGTDVDQPRNLAKSVTVE
>Mature_610_residues
MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVLTNDGTLERTRRVGKVSELDAALAEHPLVGRLGIAHTRWATHGA
PNERNAHPHFSGGIAVVHNGIIENHEALREQLKALGYVFTSDTDTEVIAHLLTHKLKDLHDLTVALKATVKELHGAYGLA
VINAQQPDRLVAARSGSPLVIGLGLGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWDVNGQAVERQTVQYSDG
AEAAEKGEYRHYMLKEIHEQPVVVQRTLEGRLSENQVLVQAFGPQAAELFVKVRNVQIVACGTSYHAGMVARYWLEELAG
IPCQVEVASEFRYRKVVVQPDTLFVTISQSGETADTLAALRNAKELGFLASLAICNVGISSLVRESDLTLLTQAGREIGV
ASTKAFTTQLVGLLLLTLSLGQVRGTLADGVEARLVEELRRLPTRLGEALAMDGTVEKIAELFAEKNHTLFLGRGAQFPV
AMEGALKLKEISYIHAEAYPAGELKHGPLALVDNDMPVVTVAPNNELLEKLKSNLQEVRARGGELIVFADEKAGMTNGEG
THVVQMPHIHDILSPILYTIPLQLLSYYVAVLKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=37.7906976744186, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=37.9360465116279, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI29570798, Length=263, Percent_Identity=28.5171102661597, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=63.6065573770492, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=218, Percent_Identity=27.9816513761468, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082251, Length=342, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=41.1627906976744, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=40.4597701149425, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=40.4597701149425, Blast_Score=284, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=453, Percent_Identity=38.6313465783664, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=30.365296803653, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=40.8653846153846, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=26.9461077844311, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=37.8102189781022, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI28573187, Length=261, Percent_Identity=27.9693486590038, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66451; Mature: 66451

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVLTNDGTLERTRRVGKVSELDAALA
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHH
EHPLVGRLGIAHTRWATHGAPNERNAHPHFSGGIAVVHNGIIENHEALREQLKALGYVFT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHHCEEEE
SDTDTEVIAHLLTHKLKDLHDLTVALKATVKELHGAYGLAVINAQQPDRLVAARSGSPLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEE
IGLGLGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWDVNGQAVERQTVQYSDG
EEECCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHCCCCEEEEECCCCCHHHHEEECCCC
AEAAEKGEYRHYMLKEIHEQPVVVQRTLEGRLSENQVLVQAFGPQAAELFVKVRNVQIVA
CCHHHCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEEECCCHHHHHHEEEECEEEEE
CGTSYHAGMVARYWLEELAGIPCQVEVASEFRYRKVVVQPDTLFVTISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHCCCEEEEEECCCEEEEEEECCCCHHHHHHHH
RNAKELGFLASLAICNVGISSLVRESDLTLLTQAGREIGVASTKAFTTQLVGLLLLTLSL
HHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GQVRGTLADGVEARLVEELRRLPTRLGEALAMDGTVEKIAELFAEKNHTLFLGRGAQFPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCE
AMEGALKLKEISYIHAEAYPAGELKHGPLALVDNDMPVVTVAPNNELLEKLKSNLQEVRA
EECCCEEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGELIVFADEKAGMTNGEGTHVVQMPHIHDILSPILYTIPLQLLSYYVAVLKGTDVDQP
CCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAERNITAILLEGLKRLEYRGYDSAGVAVLTNDGTLERTRRVGKVSELDAALA
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHH
EHPLVGRLGIAHTRWATHGAPNERNAHPHFSGGIAVVHNGIIENHEALREQLKALGYVFT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHHCEEEE
SDTDTEVIAHLLTHKLKDLHDLTVALKATVKELHGAYGLAVINAQQPDRLVAARSGSPLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEE
IGLGLGENFLASDQLALRQVTDRFMYLEEGDIAEIRRDSVQIWDVNGQAVERQTVQYSDG
EEECCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHCCCCEEEEECCCCCHHHHEEECCCC
AEAAEKGEYRHYMLKEIHEQPVVVQRTLEGRLSENQVLVQAFGPQAAELFVKVRNVQIVA
CCHHHCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEEECCCHHHHHHEEEECEEEEE
CGTSYHAGMVARYWLEELAGIPCQVEVASEFRYRKVVVQPDTLFVTISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHCCCEEEEEECCCEEEEEEECCCCHHHHHHHH
RNAKELGFLASLAICNVGISSLVRESDLTLLTQAGREIGVASTKAFTTQLVGLLLLTLSL
HHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GQVRGTLADGVEARLVEELRRLPTRLGEALAMDGTVEKIAELFAEKNHTLFLGRGAQFPV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCE
AMEGALKLKEISYIHAEAYPAGELKHGPLALVDNDMPVVTVAPNNELLEKLKSNLQEVRA
EECCCEEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGELIVFADEKAGMTNGEGTHVVQMPHIHDILSPILYTIPLQLLSYYVAVLKGTDVDQP
CCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]