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The map label for this gene is hemC [H]

Identifier: 77461708

GI number: 77461708

Start: 6154648

End: 6155589

Strand: Reverse

Name: hemC [H]

Synonym: Pfl01_5487

Alternate gene names: 77461708

Gene position: 6155589-6154648 (Counterclockwise)

Preceding gene: 77461709

Following gene: 77461707

Centisome position: 95.61

GC content: 64.12

Gene sequence:

>942_bases
ATGTCCTCTCGCGAAATCCGCATCGCCACCCGCAAAAGTGCTCTGGCCCTCTGGCAGGCCGAATACGTCAAAGCCCGTCT
GGAAGCAGCCCACCCGGGCCTGCTGGTGACGCTGGTGCCCATGGTCAGTCGCGGCGACAAGCTGCTTGATTCGCCCCTGT
CGAAAATCGGTGGCAAGGGCCTGTTCGTCAAGGAACTGGAAACCGCGCTGCTGGAAAACGAAGCCGACATTGCCGTGCAC
TCGATGAAAGACGTGCCGATGGATTTTCCCGAAGGCCTTGGTCTGTTTTGCATCTGCGAGCGCGAAGATCCGCGTGACGC
GTTTGTCTCCAATACGTATTCCAGCCTCGATGCGTTGCCAGCCGGCAGCATCGTCGGCACGTCCAGCCTGCGCCGTCAGG
CGCAGTTGCTGACGCGCCGTCCTGATCTCGAGATCCGTTTCCTGCGCGGCAACGTCAACACCCGTCTGGCCAAGCTCGAC
GCCGGCGAGTACGACGCGATCATCCTCGCGGCAGCGGGCCTGATCCGCCTCGGTTTCGAAGATCGCATCACCTCGGCCAT
CAGCGTCGACGACAGTCTGCCGGCCGGTGGCCAGGGCGCCGTCGGTATCGAATGCCGCAGCGCCGACACTGAAATCCATG
CCTTGCTTGCGCCCCTGCATCATGCCGACACCGCTGACCGTGTCACGGCCGAGCGTGCCCTCAACAAACACCTGAATGGC
GGCTGCCAAGTGCCGATCGCCTGCTACGCCGTGCTCGAAGGCGATCAGTTGTGGCTGCGCGGGCTGGTGGGCGAGCCGAG
CGGCGGCAAGCTGCTCAACGCACAAGCCCGTGCACCGCGTGCGGCAGCCGAGACGCTGGGCGTGCAGGTGGCCGAAGACC
TGCTCAGCCAGGGCGCCGACGATATTCTCAAGGCAGTCTACGGCGAGGCAGGTCACGAGTGA

Upstream 100 bases:

>100_bases
GCATTGCAGGCCAGGGAGGCCACGCCGTTTCTGATTCAGGTCAAAGTGGATTTGGCTGAGCTGTTATTATCCGCCGTATC
TATTCAGTACGGATTGATCC

Downstream 100 bases:

>100_bases
CCGCCTGGCGCCTGCTGCTGACGCGCCCGGCGGAGGACTGTTCGGCGCTCGCCGCCGTGCTGGCCGAACAAGGGTTTTTC
AGCAGCTGTCTGCCGCTTTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSSREIRIATRKSALALWQAEYVKARLEAAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENEADIAVH
SMKDVPMDFPEGLGLFCICEREDPRDAFVSNTYSSLDALPAGSIVGTSSLRRQAQLLTRRPDLEIRFLRGNVNTRLAKLD
AGEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSADTEIHALLAPLHHADTADRVTAERALNKHLNG
GCQVPIACYAVLEGDQLWLRGLVGEPSGGKLLNAQARAPRAAAETLGVQVAEDLLSQGADDILKAVYGEAGHE

Sequences:

>Translated_313_residues
MSSREIRIATRKSALALWQAEYVKARLEAAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENEADIAVH
SMKDVPMDFPEGLGLFCICEREDPRDAFVSNTYSSLDALPAGSIVGTSSLRRQAQLLTRRPDLEIRFLRGNVNTRLAKLD
AGEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSADTEIHALLAPLHHADTADRVTAERALNKHLNG
GCQVPIACYAVLEGDQLWLRGLVGEPSGGKLLNAQARAPRAAAETLGVQVAEDLLSQGADDILKAVYGEAGHE
>Mature_312_residues
SSREIRIATRKSALALWQAEYVKARLEAAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENEADIAVHS
MKDVPMDFPEGLGLFCICEREDPRDAFVSNTYSSLDALPAGSIVGTSSLRRQAQLLTRRPDLEIRFLRGNVNTRLAKLDA
GEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSADTEIHALLAPLHHADTADRVTAERALNKHLNGG
CQVPIACYAVLEGDQLWLRGLVGEPSGGKLLNAQARAPRAAAETLGVQVAEDLLSQGADDILKAVYGEAGHE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=43.8438438438438, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=43.8438438438438, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=67.8807947019868, Blast_Score=407, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.6947040498442, Blast_Score=188, Evalue=8e-49,
Organism=Drosophila melanogaster, GI20130425, Length=264, Percent_Identity=43.5606060606061, Blast_Score=207, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33419; Mature: 33287

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSREIRIATRKSALALWQAEYVKARLEAAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKG
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCHHHHHHHHHHCCCC
LFVKELETALLENEADIAVHSMKDVPMDFPEGLGLFCICEREDPRDAFVSNTYSSLDALP
EEHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
AGSIVGTSSLRRQAQLLTRRPDLEIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFE
CCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCH
DRITSAISVDDSLPAGGQGAVGIECRSADTEIHALLAPLHHADTADRVTAERALNKHLNG
HHHHHHEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
GCQVPIACYAVLEGDQLWLRGLVGEPSGGKLLNAQARAPRAAAETLGVQVAEDLLSQGAD
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHCCCHHHHHHHHHHHHHHHHHCCHH
DILKAVYGEAGHE
HHHHHHHHCCCCC
>Mature Secondary Structure 
SSREIRIATRKSALALWQAEYVKARLEAAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKG
CCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCHHHHHHHHHHCCCC
LFVKELETALLENEADIAVHSMKDVPMDFPEGLGLFCICEREDPRDAFVSNTYSSLDALP
EEHHHHHHHHHCCCCCEEEEHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
AGSIVGTSSLRRQAQLLTRRPDLEIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFE
CCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCH
DRITSAISVDDSLPAGGQGAVGIECRSADTEIHALLAPLHHADTADRVTAERALNKHLNG
HHHHHHEECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
GCQVPIACYAVLEGDQLWLRGLVGEPSGGKLLNAQARAPRAAAETLGVQVAEDLLSQGAD
CCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECHHCCCHHHHHHHHHHHHHHHHHCCHH
DILKAVYGEAGHE
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA