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The map label for this gene is hemD [H]

Identifier: 77461707

GI number: 77461707

Start: 6153884

End: 6154651

Strand: Reverse

Name: hemD [H]

Synonym: Pfl01_5486

Alternate gene names: 77461707

Gene position: 6154651-6153884 (Counterclockwise)

Preceding gene: 77461708

Following gene: 77461706

Centisome position: 95.59

GC content: 66.93

Gene sequence:

>768_bases
GTGACCGCCTGGCGCCTGCTGCTGACGCGCCCGGCGGAGGACTGTTCGGCGCTCGCCGCCGTGCTGGCCGAACAAGGGTT
TTTCAGCAGCTGTCTGCCGCTTTTGGAAATCGCCCCTCTGCCGGTCTCTGACACAATGCGCCGCACGATCATGCAACTGC
CGCGCTACAGCGCGGTGATCGTGGTCAGCAAGCCAGCGGCGCGGATCGCGGTGGATCTGCTCGACGCTCTGCGGCTGGCG
ACGCCGACGATGCCGTGGTTCAGCGTGGGCGCGGCGACCGCCGCTATCCTTCGGGATCGGGGGCTGGATGTGAGCTTCCC
GGACGCGGGCGACGACAGCGAAGCCTTGCTGCAATTGCCGCGTCTGCTTGAGGCGGTGGCCATGCCCGGTTCACAGGTAT
TGATCCTGCGCGGGGAGGGCGGACGCGAGCTGCTGGGCGAGCGCCTGCGCACGCTTGGTGCTAGTGTCGAATACTTGGAG
TTGTACCGTCGCGACCTGCCGGACTATCCGCCGCAGGAGCTGCCCCGCAGGATTGCAGCGGAACGCCTGAACGGGCTGGT
GGTCAGCAGTGGACAGGGTTTCGAGCACCTGCGCCAACTGGCCGGCGACAGCTGGCCTGCACTGGCGCAGTTGCCGTTGT
TTGTTCCAAGCCCAAGGGTTGCCGAGCAGGCAAGTGCCGCCGGGGCCCGAACAGTTGTGGATTGTCGCGGCGCCAGTGCT
GCGGCCTTGCTGACGGCGTTACGGGAGCATCCCGTGCCCGTTCTCTAA

Upstream 100 bases:

>100_bases
GTGCGGCAGCCGAGACGCTGGGCGTGCAGGTGGCCGAAGACCTGCTCAGCCAGGGCGCCGACGATATTCTCAAGGCAGTC
TACGGCGAGGCAGGTCACGA

Downstream 100 bases:

>100_bases
TGCAAAGGATGGATACGTGAGCGAAACAGCCTTGCCTAAAGATGACGTTCAACCTGTGATCGATACACCGGTTGATGCAC
CGCCACCGGCCGCGGAACCG

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTAWRLLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVIVVSKPAARIAVDLLDALRLA
TPTMPWFSVGAATAAILRDRGLDVSFPDAGDDSEALLQLPRLLEAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLE
LYRRDLPDYPPQELPRRIAAERLNGLVVSSGQGFEHLRQLAGDSWPALAQLPLFVPSPRVAEQASAAGARTVVDCRGASA
AALLTALREHPVPVL

Sequences:

>Translated_255_residues
MTAWRLLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVIVVSKPAARIAVDLLDALRLA
TPTMPWFSVGAATAAILRDRGLDVSFPDAGDDSEALLQLPRLLEAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLE
LYRRDLPDYPPQELPRRIAAERLNGLVVSSGQGFEHLRQLAGDSWPALAQLPLFVPSPRVAEQASAAGARTVVDCRGASA
AALLTALREHPVPVL
>Mature_254_residues
TAWRLLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVIVVSKPAARIAVDLLDALRLAT
PTMPWFSVGAATAAILRDRGLDVSFPDAGDDSEALLQLPRLLEAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLEL
YRRDLPDYPPQELPRRIAAERLNGLVVSSGQGFEHLRQLAGDSWPALAQLPLFVPSPRVAEQASAAGARTVVDCRGASAA
ALLTALREHPVPVL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=249, Percent_Identity=30.9236947791165, Blast_Score=85, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27431; Mature: 27300

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAWRLLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVI
CCCHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
VVSKPAARIAVDLLDALRLATPTMPWFSVGAATAAILRDRGLDVSFPDAGDDSEALLQLP
EEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RLLEAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLELYRRDLPDYPPQELPRRIAA
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHH
ERLNGLVVSSGQGFEHLRQLAGDSWPALAQLPLFVPSPRVAEQASAAGARTVVDCRGASA
HHHCCEEEECCCCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCHH
AALLTALREHPVPVL
HHHHHHHHHCCCCCC
>Mature Secondary Structure 
TAWRLLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVI
CCHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
VVSKPAARIAVDLLDALRLATPTMPWFSVGAATAAILRDRGLDVSFPDAGDDSEALLQLP
EEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RLLEAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLELYRRDLPDYPPQELPRRIAA
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHH
ERLNGLVVSSGQGFEHLRQLAGDSWPALAQLPLFVPSPRVAEQASAAGARTVVDCRGASA
HHHCCEEEECCCCHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCHH
AALLTALREHPVPVL
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]