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The map label for this gene is trxA [H]

Identifier: 77461678

GI number: 77461678

Start: 6124706

End: 6125035

Strand: Reverse

Name: trxA [H]

Synonym: Pfl01_5457

Alternate gene names: 77461678

Gene position: 6125035-6124706 (Counterclockwise)

Preceding gene: 77461679

Following gene: 77461677

Centisome position: 95.13

GC content: 56.06

Gene sequence:

>330_bases
ATGAGCAGCGATCTGATCAAACACGTTAGCGACGCTAGCTTCGAAGCCGACGTACTCAAGGCCGAAGGCGCTGTCCTGGT
CGACTACTGGGCTGAATGGTGCGGCCCTTGCAAAATGATCGCTCCGGTTCTGGACGAGATTGCAGAGACTTACAAAGGCA
AGCTGACCGTCGCCAAGCTGAACATCGACGAAAACCAGGAAACCCCTGCCAAGCACGGCGTACGTGGTATTCCGACCCTG
ATGCTGTTCAAGAACGGCAACGTGGAAGCGACCAAGGTCGGCGCTCTGTCGAAGTCGCAACTGGCTGCTTTCCTCGACGC
CAACATCTAA

Upstream 100 bases:

>100_bases
ATCGAGTGCCATAGCAAGACTCAATCATCTGCGGCTTCCTGAACAAGGGAAGGGCGGCTATGATGGGCCACGTTTTTTTG
CTTACAACCTGGAGAATTCC

Downstream 100 bases:

>100_bases
GCGTCGCGGTAAAGATTGTCCGCAAAAAGCCCCGCAAATTGCGGGGCTTTTTGCGTATTCAGGGCTAGACGCTCCGAAAC
TCAGGTGGTACATTCGGCCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSSDLIKHVSDASFEADVLKAEGAVLVDYWAEWCGPCKMIAPVLDEIAETYKGKLTVAKLNIDENQETPAKHGVRGIPTL
MLFKNGNVEATKVGALSKSQLAAFLDANI

Sequences:

>Translated_109_residues
MSSDLIKHVSDASFEADVLKAEGAVLVDYWAEWCGPCKMIAPVLDEIAETYKGKLTVAKLNIDENQETPAKHGVRGIPTL
MLFKNGNVEATKVGALSKSQLAAFLDANI
>Mature_108_residues
SSDLIKHVSDASFEADVLKAEGAVLVDYWAEWCGPCKMIAPVLDEIAETYKGKLTVAKLNIDENQETPAKHGVRGIPTLM
LFKNGNVEATKVGALSKSQLAAFLDANI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=38.0434782608696, Blast_Score=79, Evalue=8e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=31, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=37.2093023255814, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=73.8317757009346, Blast_Score=171, Evalue=1e-44,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=36.9565217391304, Blast_Score=87, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=41.3793103448276, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=66, Percent_Identity=40.9090909090909, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=66, Percent_Identity=40.9090909090909, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=40.2597402597403, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=47.887323943662, Blast_Score=74, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=38.0952380952381, Blast_Score=68, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=42.5, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=40.5405405405405, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=33.695652173913, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17648013, Length=107, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583090, Length=107, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=32.0987654320988, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11763; Mature: 11631

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDLIKHVSDASFEADVLKAEGAVLVDYWAEWCGPCKMIAPVLDEIAETYKGKLTVAKL
CCCHHHHHHCCCCCCHHEECCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
NIDENQETPAKHGVRGIPTLMLFKNGNVEATKVGALSKSQLAAFLDANI
ECCCCCCCCHHCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SSDLIKHVSDASFEADVLKAEGAVLVDYWAEWCGPCKMIAPVLDEIAETYKGKLTVAKL
CCHHHHHHCCCCCCHHEECCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
NIDENQETPAKHGVRGIPTLMLFKNGNVEATKVGALSKSQLAAFLDANI
ECCCCCCCCHHCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]