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The map label for this gene is emrA [H]

Identifier: 77460015

GI number: 77460015

Start: 4294488

End: 4295609

Strand: Direct

Name: emrA [H]

Synonym: Pfl01_3793

Alternate gene names: 77460015

Gene position: 4294488-4295609 (Clockwise)

Preceding gene: 77460010

Following gene: 77460016

Centisome position: 66.7

GC content: 66.31

Gene sequence:

>1122_bases
ATGACCAGCATGCCCACCGTAGAACCCGATCTCGCCGTTCCGGTCAGCGCCCCCAAACCTCCCCTGCTCAAACGCCTGCT
GTTGCCCACTGCGGGTTTGGCCGCGCTGGTGCTCGCCGGCCTGTATGCCGTGCATTGGTGGGGCACGGGGCGATTTCTCG
AGGAAACCGACGATGCCTACATCGGCGGCGACGTCACGGTGATCGGGCCGAAAGTCGCCGGTTACATCGAAGAAGTGCTG
GTCAGCGACAACCAGAAGGTGAAGGCCGGCGACGTGCTGATCCGCCTCGACGCCCGCGACTACCGCGCCAATCTGGCCAA
GGCCGAAGGCGCGGTTGCCGCCGAGGAAGCGCTGCTGGCCAACCTCGACGCCACCGAACAATTGCAGCAAGCGGTGATCG
GTCAGGCCCGCGCCGGGATCGATGCTGCCAGCGCCGAAACCGCACGTTCGCGAGATGACAACGCGCGCTATAAACGTCTG
GTGACCACCAACGCGGTCTCGGTAGAAAGCGCGCAACGGGCCGACGCCACCTTCAAGACCGCACAAGCCTTGAGCGCCAA
GGCCCAGGCTGAACTGCTGGCCGCGCAGCGCCAGCTCACCGTGATCGAAACCCAGAAACAACAGGCCCGCGCCGCCCTCC
AGCAAGCCCGGGCCGAACGGGATCTGGCGCAACTCAACCTCGGCTATACCGAGCTGCGCGCCCCGGTCGACGGCGTGATC
GGCAACCGCCGCGCGCGGGTCGGCGCCTATGCACAGGCCGGTTCGCAACAGTTATCGGTAGTGCCGGCCAGCGGTCTGTG
GGTCGATGCCAATTTCAAGGAAGATCAACTGGCGCGAATGAAACCCGGCCAGCGCGTGAGCATCCGTGCCGACGTGTTGT
CCGGCCAGGAATTCCACGGCCGCCTCGACAGTCTCGCCCCGGCCAGCGGCTCGCAATTCAGCGTACTGCCGCCGGAAAAC
GCCACCGGCAACTTCACCAAGATCGTTCAGCGGGTGCCGGTGCGGATCCTGCTCGACCCGGCGGACGGCGTGCTCGGCCA
TCTGCGTCCCGGCCTGTCGGTGACCGCTGAAGTCGACACCCGCGCCCAACCTGAAACCACTGCCGTGGCCAGCGCGCCAT
GA

Upstream 100 bases:

>100_bases
GATTCATCTGACGACCGGCGATAAAAATCAATTGCCACAAAATATTACTCACGTCATATTACGGTCGTAATAGCCATTCC
GCTTCTTCAGGTATTACGCC

Downstream 100 bases:

>100_bases
GCACCGCCCTCACCGCCGCCGCGCAGCCATTCAATGCCGCCGAGATGGCGACGGCGACCAAGGTGTTCGCCTTCGCCACA
ATGTGCATCGGCATGTTCAT

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTSMPTVEPDLAVPVSAPKPPLLKRLLLPTAGLAALVLAGLYAVHWWGTGRFLEETDDAYIGGDVTVIGPKVAGYIEEVL
VSDNQKVKAGDVLIRLDARDYRANLAKAEGAVAAEEALLANLDATEQLQQAVIGQARAGIDAASAETARSRDDNARYKRL
VTTNAVSVESAQRADATFKTAQALSAKAQAELLAAQRQLTVIETQKQQARAALQQARAERDLAQLNLGYTELRAPVDGVI
GNRRARVGAYAQAGSQQLSVVPASGLWVDANFKEDQLARMKPGQRVSIRADVLSGQEFHGRLDSLAPASGSQFSVLPPEN
ATGNFTKIVQRVPVRILLDPADGVLGHLRPGLSVTAEVDTRAQPETTAVASAP

Sequences:

>Translated_373_residues
MTSMPTVEPDLAVPVSAPKPPLLKRLLLPTAGLAALVLAGLYAVHWWGTGRFLEETDDAYIGGDVTVIGPKVAGYIEEVL
VSDNQKVKAGDVLIRLDARDYRANLAKAEGAVAAEEALLANLDATEQLQQAVIGQARAGIDAASAETARSRDDNARYKRL
VTTNAVSVESAQRADATFKTAQALSAKAQAELLAAQRQLTVIETQKQQARAALQQARAERDLAQLNLGYTELRAPVDGVI
GNRRARVGAYAQAGSQQLSVVPASGLWVDANFKEDQLARMKPGQRVSIRADVLSGQEFHGRLDSLAPASGSQFSVLPPEN
ATGNFTKIVQRVPVRILLDPADGVLGHLRPGLSVTAEVDTRAQPETTAVASAP
>Mature_372_residues
TSMPTVEPDLAVPVSAPKPPLLKRLLLPTAGLAALVLAGLYAVHWWGTGRFLEETDDAYIGGDVTVIGPKVAGYIEEVLV
SDNQKVKAGDVLIRLDARDYRANLAKAEGAVAAEEALLANLDATEQLQQAVIGQARAGIDAASAETARSRDDNARYKRLV
TTNAVSVESAQRADATFKTAQALSAKAQAELLAAQRQLTVIETQKQQARAALQQARAERDLAQLNLGYTELRAPVDGVIG
NRRARVGAYAQAGSQQLSVVPASGLWVDANFKEDQLARMKPGQRVSIRADVLSGQEFHGRLDSLAPASGSQFSVLPPENA
TGNFTKIVQRVPVRILLDPADGVLGHLRPGLSVTAEVDTRAQPETTAVASAP

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=328, Percent_Identity=35.0609756097561, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788711, Length=333, Percent_Identity=34.8348348348348, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790519, Length=319, Percent_Identity=31.974921630094, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87081951, Length=316, Percent_Identity=27.2151898734177, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789637, Length=289, Percent_Identity=28.719723183391, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790024, Length=246, Percent_Identity=28.8617886178862, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790012, Length=247, Percent_Identity=27.1255060728745, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39588; Mature: 39457

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSMPTVEPDLAVPVSAPKPPLLKRLLLPTAGLAALVLAGLYAVHWWGTGRFLEETDDAY
CCCCCCCCCCCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCHHCCCCEE
IGGDVTVIGPKVAGYIEEVLVSDNQKVKAGDVLIRLDARDYRANLAKAEGAVAAEEALLA
ECCCEEEECCHHHHHHHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHCCCHHHHHHHHH
NLDATEQLQQAVIGQARAGIDAASAETARSRDDNARYKRLVTTNAVSVESAQRADATFKT
CCCHHHHHHHHHHHHHHCCCCHHCHHHHHCCCCCCHHHEEEECCCEECCHHHHHHHHHHH
AQALSAKAQAELLAAQRQLTVIETQKQQARAALQQARAERDLAQLNLGYTELRAPVDGVI
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
GNRRARVGAYAQAGSQQLSVVPASGLWVDANFKEDQLARMKPGQRVSIRADVLSGQEFHG
CCCCHHHCHHHHCCCCEEEEEECCCEEEECCCCHHHHHHCCCCCEEEEEEEECCCHHHHH
RLDSLAPASGSQFSVLPPENATGNFTKIVQRVPVRILLDPADGVLGHLRPGLSVTAEVDT
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCHHHHCCCCCEEEEECCC
RAQPETTAVASAP
CCCCCCCCCCCCC
>Mature Secondary Structure 
TSMPTVEPDLAVPVSAPKPPLLKRLLLPTAGLAALVLAGLYAVHWWGTGRFLEETDDAY
CCCCCCCCCCEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCCHHCCCCEE
IGGDVTVIGPKVAGYIEEVLVSDNQKVKAGDVLIRLDARDYRANLAKAEGAVAAEEALLA
ECCCEEEECCHHHHHHHHHHHCCCCEEEECCEEEEECCHHHHHHHHHHCCCHHHHHHHHH
NLDATEQLQQAVIGQARAGIDAASAETARSRDDNARYKRLVTTNAVSVESAQRADATFKT
CCCHHHHHHHHHHHHHHCCCCHHCHHHHHCCCCCCHHHEEEECCCEECCHHHHHHHHHHH
AQALSAKAQAELLAAQRQLTVIETQKQQARAALQQARAERDLAQLNLGYTELRAPVDGVI
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
GNRRARVGAYAQAGSQQLSVVPASGLWVDANFKEDQLARMKPGQRVSIRADVLSGQEFHG
CCCCHHHCHHHHCCCCEEEEEECCCEEEECCCCHHHHHHCCCCCEEEEEEEECCCHHHHH
RLDSLAPASGSQFSVLPPENATGNFTKIVQRVPVRILLDPADGVLGHLRPGLSVTAEVDT
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCHHHHCCCCCEEEEECCC
RAQPETTAVASAP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]