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The map label for this gene is mro [H]

Identifier: 77459953

GI number: 77459953

Start: 4216247

End: 4217395

Strand: Direct

Name: mro [H]

Synonym: Pfl01_3731

Alternate gene names: 77459953

Gene position: 4216247-4217395 (Clockwise)

Preceding gene: 77459950

Following gene: 77459954

Centisome position: 65.49

GC content: 60.92

Gene sequence:

>1149_bases
ATGCTTCAATCCCGACACTCACTCTGCGGCCTCGGACTGTCCCTGATGATCGCCACCCTCTCCGCCCAGGCCGCCGGCCT
GACCAGCGAACACAAAGCCTTCGGCAAAACCAATGACGGCACGCCGGTCGAGCAATACATCCTGCGCAACAGCCACGGCA
TGCAAGCCACGGTCATCACCTACGGCGCGACCTTGCAGGCGCTGCAAGTGCCGGACAAGCACGGCAAGCTCGACGACATC
GTCCTCGGTTTCGATGATGTGCAGGGTTATCAGAAAGGCACCGCGTACTTCGGCGCAACCATCGGCCGCTTCGGCAATCG
CCTGGCCGACGGCGCATTCGAACTCGACGGCAAGCGCTATCAAGTGCCGCAGAACGACAAGACCAACGCCTTGCACGGCG
GCACTCAGGGCTTCGACAAAAAGGTCTGGAAGGCGAAGGAAACCAAAGACAAGGATTCGGTCGGCGTGACCCTGACCTAT
CTGTCGGCGGATGGTGAAATGGGTTTCCCCGGCAACCTCACCACCGAGGTGACCTACCGCCTTACCGACTCTAACGAGCT
GCGCATCGACTACAAGGCCAGCACCGACAAACCCACTGTGCTCAACCTGACCAACCACAGCTACTTCAACCTTGCCGGCG
CCGGCAATGGCGACATCCTCAAGCAAGTCGCCACCCTGCACGCCAGCCATTACACCCCAGTCACCGCCAAGCTGATCCCG
ACCGGCGAACTGGCGCCCGTGGCCGGCACACCGATGGACTTCACCAAACCGACCGCCATCGGCCAGCACATCAAGGCCGA
CCATCCGCAGTTGAAATTCGCTGAGGAGAAACAAGGCGGCTTCGATTTCAACTGGGCGCTGGACACCAAGGGTGACGTCA
GCAAACTCGCCGCCGAAGTCAGCGACCCGCAATCCGGTCGCCACTTGCAGCTGTACACCAACGAACCGGGCGTGCAGTTC
TACACCAGCAACTTCCTCGACGGCACGGTCAAGGGCAAGGGTGGCAAGGTCTATCCGCACTGGGGAGCGTTCACTCTGGA
AACCCAGCATTATCCGGACTCGCCGAACCAGCCGAACTTCCCGAGTACCCGCCTCGATCCCGGCCAGACCTACACCCAGA
GCGTGGTGTTGAAGTTCTCCGCCAAGTAA

Upstream 100 bases:

>100_bases
TTGCAATAAATGCTAAATCCGCTATAAACCTTCATTAACACCATAATTAGCATGACTATTTATCGATTTTCAAAACAACA
ACAAAAAGGAAGGTCAACCC

Downstream 100 bases:

>100_bases
GCACCTGACCTCCTTTCTGGAACCGGACGGAACCCGTGGGCTATTCTGCTGCCCACCCAAGGTATCGACCCTTTCAGAAA
GGAGGTTTGAATGCGTACCC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLQSRHSLCGLGLSLMIATLSAQAAGLTSEHKAFGKTNDGTPVEQYILRNSHGMQATVITYGATLQALQVPDKHGKLDDI
VLGFDDVQGYQKGTAYFGATIGRFGNRLADGAFELDGKRYQVPQNDKTNALHGGTQGFDKKVWKAKETKDKDSVGVTLTY
LSADGEMGFPGNLTTEVTYRLTDSNELRIDYKASTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVTAKLIP
TGELAPVAGTPMDFTKPTAIGQHIKADHPQLKFAEEKQGGFDFNWALDTKGDVSKLAAEVSDPQSGRHLQLYTNEPGVQF
YTSNFLDGTVKGKGGKVYPHWGAFTLETQHYPDSPNQPNFPSTRLDPGQTYTQSVVLKFSAK

Sequences:

>Translated_382_residues
MLQSRHSLCGLGLSLMIATLSAQAAGLTSEHKAFGKTNDGTPVEQYILRNSHGMQATVITYGATLQALQVPDKHGKLDDI
VLGFDDVQGYQKGTAYFGATIGRFGNRLADGAFELDGKRYQVPQNDKTNALHGGTQGFDKKVWKAKETKDKDSVGVTLTY
LSADGEMGFPGNLTTEVTYRLTDSNELRIDYKASTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVTAKLIP
TGELAPVAGTPMDFTKPTAIGQHIKADHPQLKFAEEKQGGFDFNWALDTKGDVSKLAAEVSDPQSGRHLQLYTNEPGVQF
YTSNFLDGTVKGKGGKVYPHWGAFTLETQHYPDSPNQPNFPSTRLDPGQTYTQSVVLKFSAK
>Mature_382_residues
MLQSRHSLCGLGLSLMIATLSAQAAGLTSEHKAFGKTNDGTPVEQYILRNSHGMQATVITYGATLQALQVPDKHGKLDDI
VLGFDDVQGYQKGTAYFGATIGRFGNRLADGAFELDGKRYQVPQNDKTNALHGGTQGFDKKVWKAKETKDKDSVGVTLTY
LSADGEMGFPGNLTTEVTYRLTDSNELRIDYKASTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVTAKLIP
TGELAPVAGTPMDFTKPTAIGQHIKADHPQLKFAEEKQGGFDFNWALDTKGDVSKLAAEVSDPQSGRHLQLYTNEPGVQF
YTSNFLDGTVKGKGGKVYPHWGAFTLETQHYPDSPNQPNFPSTRLDPGQTYTQSVVLKFSAK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=343, Percent_Identity=45.7725947521866, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1786971, Length=346, Percent_Identity=38.150289017341, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17557428, Length=343, Percent_Identity=32.3615160349854, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI115533334, Length=343, Percent_Identity=32.3615160349854, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=29.4460641399417, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=28.8515406162465, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=347, Percent_Identity=27.6657060518732, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24659048, Length=358, Percent_Identity=41.8994413407821, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24668282, Length=349, Percent_Identity=40.974212034384, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24583720, Length=368, Percent_Identity=38.3152173913043, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24668278, Length=369, Percent_Identity=36.0433604336043, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24641876, Length=353, Percent_Identity=32.2946175637394, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41479; Mature: 41479

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSRHSLCGLGLSLMIATLSAQAAGLTSEHKAFGKTNDGTPVEQYILRNSHGMQATVIT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEE
YGATLQALQVPDKHGKLDDIVLGFDDVQGYQKGTAYFGATIGRFGNRLADGAFELDGKRY
ECCEEEEEECCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEE
QVPQNDKTNALHGGTQGFDKKVWKAKETKDKDSVGVTLTYLSADGEMGFPGNLTTEVTYR
ECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEE
LTDSNELRIDYKASTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVTAKLIP
EECCCEEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEC
TGELAPVAGTPMDFTKPTAIGQHIKADHPQLKFAEEKQGGFDFNWALDTKGDVSKLAAEV
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEHHCCCCCEEEEEECCCCCHHHHHHHC
SDPQSGRHLQLYTNEPGVQFYTSNFLDGTVKGKGGKVYPHWGAFTLETQHYPDSPNQPNF
CCCCCCCEEEEEECCCCCEEEECCCCCCEEECCCCEECCCCCEEEEEECCCCCCCCCCCC
PSTRLDPGQTYTQSVVLKFSAK
CCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MLQSRHSLCGLGLSLMIATLSAQAAGLTSEHKAFGKTNDGTPVEQYILRNSHGMQATVIT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEE
YGATLQALQVPDKHGKLDDIVLGFDDVQGYQKGTAYFGATIGRFGNRLADGAFELDGKRY
ECCEEEEEECCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEE
QVPQNDKTNALHGGTQGFDKKVWKAKETKDKDSVGVTLTYLSADGEMGFPGNLTTEVTYR
ECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEE
LTDSNELRIDYKASTDKPTVLNLTNHSYFNLAGAGNGDILKQVATLHASHYTPVTAKLIP
EECCCEEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEC
TGELAPVAGTPMDFTKPTAIGQHIKADHPQLKFAEEKQGGFDFNWALDTKGDVSKLAAEV
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEHHCCCCCEEEEEECCCCCHHHHHHHC
SDPQSGRHLQLYTNEPGVQFYTSNFLDGTVKGKGGKVYPHWGAFTLETQHYPDSPNQPNF
CCCCCCCEEEEEECCCCCEEEECCCCCCEEECCCCEECCCCCEEEEEECCCCCCCCCCCC
PSTRLDPGQTYTQSVVLKFSAK
CCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]