Click here to switch to the map view.

The map label for this gene is srpA [H]

Identifier: 77459887

GI number: 77459887

Start: 4148592

End: 4149686

Strand: Reverse

Name: srpA [H]

Synonym: Pfl01_3665

Alternate gene names: 77459887

Gene position: 4149686-4148592 (Counterclockwise)

Preceding gene: 77459890

Following gene: 77459886

Centisome position: 64.45

GC content: 62.92

Gene sequence:

>1095_bases
ATGGTTGATCGCAGCTCATCGCCCGGCGGGCCACAACGCCCGCCACTGAGTGCCGCGAGCCTGGTGTTGCGTCTTGGCGG
AATCGCCGTGGTCGTCGCAGCCCTGGCCGGGGCCTTTGCCTACGTTCATGGTTCATTTGACCCACAACGTCTGACGCCTA
AAGCGTTGGTCGATGTGCTGGAAAAGAACAACGGCGTGCATCCCGGCTTTCGCCGCAATCACGCCAAAGGTGTGTGCGTG
ATCGGACATTTCGAGAGCAGCGGCGAGGCTCGCGCGTATTCTGTCGCGCAAGTGTTCAACGAGCCGCGCACCCGGGTGGT
CGGGCGCTTTGCGTTGCCGGCTGGCAGTCCGTATGCGCCGGACAGCGCCGTACCGATCCGCAGTCTGGCGCTGCGTTTCA
CTCAGGCCAACGGCCAGCAGTGGCGCACCGGGATGAACAGCATGCCGGTGTTCCCGGTTGGCACGCCCGAGGCGTTCTAT
CAATTGCAGCAGGCGCAATCGCCGGATCCCGCCACCGGTAAACCGGACCCGACCAAGGTGCCGGCATTTTTTGCCGCACA
CCCGGAAGCCGTGCCGTTTCTGACCTGGATTAAAACCGCCAAACCTTCGGCCAGTTACGCGACGGAAACCTACAACAGTG
TCAACGCGTTCTATCTGGTGGATGCCAGCGGCAAGAAGCAGGCGGTGCGCTGGAGCATGACGCCTCTGGCTCAGGACGCT
GCCGGTGCGACCGCGCCTGAAGGTAGCGATTTCCTTGAAAAAGACCTGGTGCAGCGCCTGGCCGAAGGGCCGCTGCGCTT
TCAGTTGAACATCACCTTGGCCAACGCCGACGATCCGGTGAACGATGCGAGCAAGACCTGGCCTGCCGGTCGCAAGGTGT
TGAACGCCGGCACCCTGGTACTGGAAAAGACCCAGCCGCAGCTCAGCGGCGAATGCCGTGACATCAACTACGATCCGCTG
GTGCTGCCGGCCGGCATTCAGGGTTCCGACGATCCGTTGCTGGCCGCACGCTCGGCCGGTTATGCCGATTCCTACCTGCG
TCGCACCAGCGAAGTCAGCCAACTGCCAACCGGCAAAAAGGAGGCTCGCCCATGA

Upstream 100 bases:

>100_bases
TCCACGTTCTGAAAAATAAATACCGGGCCGTGGAATAAATCCCGATGACGTGCGTCTTGCTGATTCTTCCTACTTGTGGC
CGATGGCCCTGGAGTGCTTC

Downstream 100 bases:

>100_bases
GCACGCAACCAACTCATTTCAATCCGCTGGCGCGGTTGCTGCACTGGCTGATGGCGTTGATGATCATCGCAATGTTGTTC
ATCGGCGCCGGTATGGTGAC

Product: catalase-like protein

Products: O2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MVDRSSSPGGPQRPPLSAASLVLRLGGIAVVVAALAGAFAYVHGSFDPQRLTPKALVDVLEKNNGVHPGFRRNHAKGVCV
IGHFESSGEARAYSVAQVFNEPRTRVVGRFALPAGSPYAPDSAVPIRSLALRFTQANGQQWRTGMNSMPVFPVGTPEAFY
QLQQAQSPDPATGKPDPTKVPAFFAAHPEAVPFLTWIKTAKPSASYATETYNSVNAFYLVDASGKKQAVRWSMTPLAQDA
AGATAPEGSDFLEKDLVQRLAEGPLRFQLNITLANADDPVNDASKTWPAGRKVLNAGTLVLEKTQPQLSGECRDINYDPL
VLPAGIQGSDDPLLAARSAGYADSYLRRTSEVSQLPTGKKEARP

Sequences:

>Translated_364_residues
MVDRSSSPGGPQRPPLSAASLVLRLGGIAVVVAALAGAFAYVHGSFDPQRLTPKALVDVLEKNNGVHPGFRRNHAKGVCV
IGHFESSGEARAYSVAQVFNEPRTRVVGRFALPAGSPYAPDSAVPIRSLALRFTQANGQQWRTGMNSMPVFPVGTPEAFY
QLQQAQSPDPATGKPDPTKVPAFFAAHPEAVPFLTWIKTAKPSASYATETYNSVNAFYLVDASGKKQAVRWSMTPLAQDA
AGATAPEGSDFLEKDLVQRLAEGPLRFQLNITLANADDPVNDASKTWPAGRKVLNAGTLVLEKTQPQLSGECRDINYDPL
VLPAGIQGSDDPLLAARSAGYADSYLRRTSEVSQLPTGKKEARP
>Mature_364_residues
MVDRSSSPGGPQRPPLSAASLVLRLGGIAVVVAALAGAFAYVHGSFDPQRLTPKALVDVLEKNNGVHPGFRRNHAKGVCV
IGHFESSGEARAYSVAQVFNEPRTRVVGRFALPAGSPYAPDSAVPIRSLALRFTQANGQQWRTGMNSMPVFPVGTPEAFY
QLQQAQSPDPATGKPDPTKVPAFFAAHPEAVPFLTWIKTAKPSASYATETYNSVNAFYLVDASGKKQAVRWSMTPLAQDA
AGATAPEGSDFLEKDLVQRLAEGPLRFQLNITLANADDPVNDASKTWPAGRKVLNAGTLVLEKTQPQLSGECRDINYDPL
VLPAGIQGSDDPLLAARSAGYADSYLRRTSEVSQLPTGKKEARP

Specific function: Decomposes Hydrogen Peroxide Into Water And Oxygen; Serves To Protect Cells From The Toxic Effects Of Hydrogen Peroxide. [C]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=293, Percent_Identity=26.962457337884, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI48994891, Length=296, Percent_Identity=23.9864864864865, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998444, Length=305, Percent_Identity=25.9016393442623, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920968, Length=292, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17981717, Length=293, Percent_Identity=23.5494880546075, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020835
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase [H]

EC number: 1.11.1.6

Molecular weight: Translated: 38876; Mature: 38876

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDRSSSPGGPQRPPLSAASLVLRLGGIAVVVAALAGAFAYVHGSFDPQRLTPKALVDVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCHHHHHHHH
EKNNGVHPGFRRNHAKGVCVIGHFESSGEARAYSVAQVFNEPRTRVVGRFALPAGSPYAP
HHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHEEEEEECCCCCCCCC
DSAVPIRSLALRFTQANGQQWRTGMNSMPVFPVGTPEAFYQLQQAQSPDPATGKPDPTKV
CCCCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCC
PAFFAAHPEAVPFLTWIKTAKPSASYATETYNSVNAFYLVDASGKKQAVRWSMTPLAQDA
CEEEECCCCCCHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCCEEEEECCCHHHHH
AGATAPEGSDFLEKDLVQRLAEGPLRFQLNITLANADDPVNDASKTWPAGRKVLNAGTLV
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHCCCHHHHHHCCCEEE
LEKTQPQLSGECRDINYDPLVLPAGIQGSDDPLLAARSAGYADSYLRRTSEVSQLPTGKK
EECCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCC
EARP
CCCC
>Mature Secondary Structure
MVDRSSSPGGPQRPPLSAASLVLRLGGIAVVVAALAGAFAYVHGSFDPQRLTPKALVDVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCHHHHHHHH
EKNNGVHPGFRRNHAKGVCVIGHFESSGEARAYSVAQVFNEPRTRVVGRFALPAGSPYAP
HHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHEEEEEECCCCCCCCC
DSAVPIRSLALRFTQANGQQWRTGMNSMPVFPVGTPEAFYQLQQAQSPDPATGKPDPTKV
CCCCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCC
PAFFAAHPEAVPFLTWIKTAKPSASYATETYNSVNAFYLVDASGKKQAVRWSMTPLAQDA
CEEEECCCCCCHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCCEEEEECCCHHHHH
AGATAPEGSDFLEKDLVQRLAEGPLRFQLNITLANADDPVNDASKTWPAGRKVLNAGTLV
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHCCCHHHHHHCCCEEE
LEKTQPQLSGECRDINYDPLVLPAGIQGSDDPLLAARSAGYADSYLRRTSEVSQLPTGKK
EECCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCC
EARP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Heme Group. [C]

Metal ions: NA

Kcat value (1/min): 980000 [C]

Specific activity: NA

Km value (mM): 18.2 {H2O2}} 10 {H2O2}} 3.7 {H2O2}} [C]

Substrates: H2O2

Specific reaction: 2 H2O2 = O2 + 2 H2O

General reaction: Redox reaction [C]

Inhibitor: 3-Amino-1-H-1, 2, 4-triazolecoli, Rhodopseudomonascapsulata; Dianisidine; H2O2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7536734 [H]