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The map label for this gene is nuoM [H]

Identifier: 77459836

GI number: 77459836

Start: 4084899

End: 4086431

Strand: Direct

Name: nuoM [H]

Synonym: Pfl01_3614

Alternate gene names: 77459836

Gene position: 4084899-4086431 (Clockwise)

Preceding gene: 77459835

Following gene: 77459837

Centisome position: 63.45

GC content: 60.67

Gene sequence:

>1533_bases
ATGATTCTGCCTTGGCTAATCCTGATCCCCTTCATCGGCGGCCTGCTGTGCTGGCTGGGTGAGCGCTTCGGCGCCACCCT
CCCCCGCTGGATTGCGCTGTTGACCATGACCCTGGAACTCGCCCTCGGCCTCTGGCTGTGGGCCCACGGTGACTATTCAT
TTGCACCGGCGCCAGGCGCCGATCCGACCTGGGCGCTTGAGTTCAAGCACGTCTGGATCCAGCGCTTCGGCATCAACGTG
CACCTGGCCCTCGACGGCCTGTCGCTGCTGATGATCCTGTTGACCGGCCTGCTGGGTATCCTGTCGGTACTCTGCTCGTG
GAAAGAGATTCAACGTCACGTTGGCTTCTTCCACCTGAACCTGATGTGGATCCTGGGCGGCGTTGTCGGCGTGTTCCTCG
CCCTCGACCTGTTCATGTTCTTCTTCTTCTGGGAAATGATGCTGGTGCCGATGTACTTCCTCATCGCGCTCTGGGGTCAC
AGTTCTTCGGACGGCAAGAAAACCCGTATCTACGCCGCGACCAAGTTCTTCATCTTCACTCAGGCTTCCGGCCTGATCAT
GCTGGTGGCGATCCTCGGTCTGGTCCTGGTCAACTACAACAGCACCGGCGTGATCACCTTCAACTACGCCGATCTGTTGA
AGACCAAGATGTCGATGACCACCGAGTACATCCTGATGCTCGGCTTCTTCATCGCCTTCGCGGTCAAGCTGCCCGTGGTT
CCGTTCCACTCCTGGCTGCCTGACGCTCACGCCCAGGCGCCGACTGCAGGTTCCGTCGACCTCGCCGGTATCTTGCTGAA
AACCGCGGCCTACGGTCTGCTGCGTTTCGCCCTGCCGCTGTTCCCGAACGCCTCGGCCGAGTTCGCGCCGATCGCCATGA
CCCTCGGTCTGATCGGGATCTTCTACGGTGCGTTCCTCGCTTTCGCGCAAACCGACATCAAGCGTCTGATCGCCTTCTCG
TCCGTTTCCCACATGGGCTTCGTACTGATCGGCATCTACTCCGGCAGCCAACTGGCCCTGCAAGGTGCAGTGATCCAGAT
GCTGGCGCACGGTCTGTCGGCCGCAGCACTGTTTATCCTCAGCGGTCAGCTGTACGAGCGCCTGCACACTCGTGACATGC
GTGAGATGGGCGGTCTGTGGTCGCGCATCGCTTACCTGCCGGCGATCAGCCTGTTCTTCGCAGCCGCCTCTCTTGGTCTG
CCGGGCACCGGTAACTTCGTCGGCGAGTTCCTGATCCTGATCGGTACCTTCGCCAGTGCTCCATGGATCACCGCGATTGC
CACCTCCGGTCTGGTGTTCGGTTCGGTCTACTCGCTGATCATGATCCACCGCGCTTACTTCGGTCCGTCCAAATCGGATT
CGATCCTGCACGGCATGGACGGTCGCGAACTGATCATGGTGCTGGGCCTTGCGGTACTGCTGATTTACCTCGGCGTCTAC
CCGCAACCGTTCCTCGACACTTCTGCCGCCACGATGCATGGCGTGCAGCAGTGGCTCGGCACCGCCTTCACTCAACTCGC
TTCGGCCCGGTAA

Upstream 100 bases:

>100_bases
TGCTTCGATGGCTGCTGGTGCCGTGTTGGTCATCGGCGCTGTCGTGCTGGTAGCGGTCTGATATGAACCTTGCGAATTTG
CGAAAGGAAACGAGCCCGTC

Downstream 100 bases:

>100_bases
GAGCGCTATGGAATTCACGATTCAACACTTTATTGCGCTTGCGCCACTGTTGATCACCAGCCTCACCATTATCGTGGTGA
TGCTGGCAATCGCCTGGCGC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MILPWLILIPFIGGLLCWLGERFGATLPRWIALLTMTLELALGLWLWAHGDYSFAPAPGADPTWALEFKHVWIQRFGINV
HLALDGLSLLMILLTGLLGILSVLCSWKEIQRHVGFFHLNLMWILGGVVGVFLALDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVNYNSTGVITFNYADLLKTKMSMTTEYILMLGFFIAFAVKLPVV
PFHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLIGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQLALQGAVIQMLAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYLPAISLFFAAASLGL
PGTGNFVGEFLILIGTFASAPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDSILHGMDGRELIMVLGLAVLLIYLGVY
PQPFLDTSAATMHGVQQWLGTAFTQLASAR

Sequences:

>Translated_510_residues
MILPWLILIPFIGGLLCWLGERFGATLPRWIALLTMTLELALGLWLWAHGDYSFAPAPGADPTWALEFKHVWIQRFGINV
HLALDGLSLLMILLTGLLGILSVLCSWKEIQRHVGFFHLNLMWILGGVVGVFLALDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVNYNSTGVITFNYADLLKTKMSMTTEYILMLGFFIAFAVKLPVV
PFHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLIGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQLALQGAVIQMLAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYLPAISLFFAAASLGL
PGTGNFVGEFLILIGTFASAPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDSILHGMDGRELIMVLGLAVLLIYLGVY
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
>Mature_510_residues
MILPWLILIPFIGGLLCWLGERFGATLPRWIALLTMTLELALGLWLWAHGDYSFAPAPGADPTWALEFKHVWIQRFGINV
HLALDGLSLLMILLTGLLGILSVLCSWKEIQRHVGFFHLNLMWILGGVVGVFLALDLFMFFFFWEMMLVPMYFLIALWGH
SSSDGKKTRIYAATKFFIFTQASGLIMLVAILGLVLVNYNSTGVITFNYADLLKTKMSMTTEYILMLGFFIAFAVKLPVV
PFHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLIGIFYGAFLAFAQTDIKRLIAFS
SVSHMGFVLIGIYSGSQLALQGAVIQMLAHGLSAAALFILSGQLYERLHTRDMREMGGLWSRIAYLPAISLFFAAASLGL
PGTGNFVGEFLILIGTFASAPWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDSILHGMDGRELIMVLGLAVLLIYLGVY
PQPFLDTSAATMHGVQQWLGTAFTQLASAR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=338, Percent_Identity=32.8402366863905, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI251831117, Length=210, Percent_Identity=32.3809523809524, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788613, Length=507, Percent_Identity=73.3727810650888, Blast_Score=727, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=309, Percent_Identity=27.831715210356, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788831, Length=363, Percent_Identity=27.5482093663912, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI145693160, Length=394, Percent_Identity=27.4111675126904, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788614, Length=453, Percent_Identity=27.1523178807947, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788829, Length=209, Percent_Identity=27.7511961722488, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI2367154, Length=316, Percent_Identity=23.4177215189873, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55861; Mature: 55861

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPWLILIPFIGGLLCWLGERFGATLPRWIALLTMTLELALGLWLWAHGDYSFAPAPGA
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DPTWALEFKHVWIQRFGINVHLALDGLSLLMILLTGLLGILSVLCSWKEIQRHVGFFHLN
CCCEEHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMWILGGVVGVFLALDLFMFFFFWEMMLVPMYFLIALWGHSSSDGKKTRIYAATKFFIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEE
QASGLIMLVAILGLVLVNYNSTGVITFNYADLLKTKMSMTTEYILMLGFFIAFAVKLPVV
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLIGI
CCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FYGAFLAFAQTDIKRLIAFSSVSHMGFVLIGIYSGSQLALQGAVIQMLAHGLSAAALFIL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SGQLYERLHTRDMREMGGLWSRIAYLPAISLFFAAASLGLPGTGNFVGEFLILIGTFASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDSILHGMDGRELIMVLGLAVLLIYLGVY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCC
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILPWLILIPFIGGLLCWLGERFGATLPRWIALLTMTLELALGLWLWAHGDYSFAPAPGA
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DPTWALEFKHVWIQRFGINVHLALDGLSLLMILLTGLLGILSVLCSWKEIQRHVGFFHLN
CCCEEHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMWILGGVVGVFLALDLFMFFFFWEMMLVPMYFLIALWGHSSSDGKKTRIYAATKFFIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEE
QASGLIMLVAILGLVLVNYNSTGVITFNYADLLKTKMSMTTEYILMLGFFIAFAVKLPVV
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMTLGLIGI
CCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
FYGAFLAFAQTDIKRLIAFSSVSHMGFVLIGIYSGSQLALQGAVIQMLAHGLSAAALFIL
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SGQLYERLHTRDMREMGGLWSRIAYLPAISLFFAAASLGLPGTGNFVGEFLILIGTFASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PWITAIATSGLVFGSVYSLIMIHRAYFGPSKSDSILHGMDGRELIMVLGLAVLLIYLGVY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCC
PQPFLDTSAATMHGVQQWLGTAFTQLASAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]