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The map label for this gene is nuoL [H]

Identifier: 77459835

GI number: 77459835

Start: 4083006

End: 4084859

Strand: Direct

Name: nuoL [H]

Synonym: Pfl01_3613

Alternate gene names: 77459835

Gene position: 4083006-4084859 (Clockwise)

Preceding gene: 77459834

Following gene: 77459836

Centisome position: 63.42

GC content: 61.33

Gene sequence:

>1854_bases
ATGAACCTACTCTTTCTGACTTTCGTATTCCCTCTGATCGGGTTCCTGTTGCTGTCGTTCTCGCGCGGCCGCTTCTCGGA
AAACCTGTCGGCGCTGATCGGTGTCGGCTCCATCGGCCTGTCTGCCATCGTCGCGGCCTACGTGATCTGGCAGTTCAACG
TCGCGCCACCGGAAGGCGGCGTCTACACCCAGGTGCTGTGGCGCTGGATGTCGGTGGAAGGTTTCCAGCCTAACTTCGCG
CTGTACCTGGATGGTCTGTCCGTGACCATGCTCGGTGTGGTCGTCGGTGTCGGCTTCCTGATCCACCTGTTTGCATCGTG
GTACATGCGTGGCGAAGCCGGTTACTCGCGCTTCTTCTCGTACACCAACCTGTTTATCGCCAGCATGCTGTTCCTGATCC
TGGGCGATAACCTGCTGTTCATCTACTTCGGTTGGGAAGGCGTGGGCCTGTGCTCGTACCTGTTGATCGGTTTCTACTAC
AGCAACCGCAACAACGGTAACGCCGCACTGAAAGCCTTCATCGTCACCCGTATCGGCGACGTGTTCATGGCAATCGGCCT
GTTCATCCTGTTCCAGCAACTGGGCACGCTGAACGTCCAGGAACTGCTGGTGAAGGCGCCTGAGCACTTCAAGGTCGGCG
ATTTCTGGATCGTGCTTGCTACCCTGATGCTGTTGGGTGGTGCGGTCGGTAAATCGGCGCAACTGCCGCTGCAAACCTGG
CTGGCAGACGCGATGGCCGGCCCTACCCCGGTTTCGGCACTGATCCATGCCGCAACCATGGTGACCGCCGGTGTCTACCT
GATCGCCCGTACCCACGGCCTGTTCGCCCTGGCGCCGGACATCCTGCACCTGGTCGGCATCGTCGGTGGTGTGACCCTGG
TGCTGGCCGGTTTCGCCGCACTGGTGCAAACCGACATCAAACGTATCCTCGCCTACTCGACCATGAGCCAGATCGGCTAC
ATGTTCCTGGCGCTGGGCGTTGGCGCCTGGGAAGGCGCGATCTTCCACCTGATGACCCACGCCTTCTTCAAGGCCCTGCT
GTTCCTTGCTTCCGGTGCGGTGATCGTTGCCTGCCACCACGAGCAGAACATCTTCAAGATGGGCGGCCTGTGGAAGAAAC
TGCCGCTGGCCTACGCCAGCTTCATCGTCGGTGGTGCCGCTCTGGCTGCCCTGCCACTGTTGACCGCAGGTTTCTACTCC
AAGGACGAAATCCTCTGGGAAGCGTTCGCCAGCGGCAACCACGGTCTGCTTTACGCAGGTCTGGTCGGCGCATTCATGAC
GTCGCTGTACACCTTCCGCCTGATCTTCATCGCGTTCCACGGTGAAGCCAAGACCGAAGCCCACGCCGGTCACGGCATCG
CTCACTGGCTGCCGCTGTCGGTGCTGATCGTGCTGTCGACTTTCGTCGGCGCCATGATCGTTCCACCGCTGCACGGCGTA
CTGCCTGAGAGCGTTGGCCATGCCGGTGGCGAAGCCAAGCACAGTCTGGAAATCGCTTCGGGCGCCATCGCCCTGGCCGG
TATCCTGCTGGCGGCCCTGCTGTTCCTCGGCAAGCGTCGCTTCGTGACCGCGATCGCCAACAGCGGCATCGGCCGTCTCC
TTTCGGCCTGGTGGTTCGCTGCCTGGGGCTTCGACTGGATCTACGACAAACTGTTCGTCAAGCCGTACCTTGCGATCAGC
CACATGCTGCGCAAAGACCCGCTCGACCAGACCATCGGTCTGATCCCGCGCATGGCCAAGGGGGGTCACACCGCCCTGAG
CCGTACCGAAACCGGTCAACTGCGTTGGTACGCTGCTTCGATGGCTGCTGGTGCCGTGTTGGTCATCGGCGCTGTCGTGC
TGGTAGCGGTCTGA

Upstream 100 bases:

>100_bases
GCCTTGCAGCCGCCGAAGCCAGTATTGGCCTGGCGATCCTGCTGCAACTGTATCGCCGCTTCCACACGCTCGATATCGAC
GCTGCCAGTGAGATGCGCGG

Downstream 100 bases:

>100_bases
TATGAACCTTGCGAATTTGCGAAAGGAAACGAGCCCGTCATGATTCTGCCTTGGCTAATCCTGATCCCCTTCATCGGCGG
CCTGCTGTGCTGGCTGGGTG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MNLLFLTFVFPLIGFLLLSFSRGRFSENLSALIGVGSIGLSAIVAAYVIWQFNVAPPEGGVYTQVLWRWMSVEGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVKAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALAALPLLTAGFYS
KDEILWEAFASGNHGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFVGAMIVPPLHGV
LPESVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRFVTAIANSGIGRLLSAWWFAAWGFDWIYDKLFVKPYLAIS
HMLRKDPLDQTIGLIPRMAKGGHTALSRTETGQLRWYAASMAAGAVLVIGAVVLVAV

Sequences:

>Translated_617_residues
MNLLFLTFVFPLIGFLLLSFSRGRFSENLSALIGVGSIGLSAIVAAYVIWQFNVAPPEGGVYTQVLWRWMSVEGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVKAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALAALPLLTAGFYS
KDEILWEAFASGNHGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFVGAMIVPPLHGV
LPESVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRFVTAIANSGIGRLLSAWWFAAWGFDWIYDKLFVKPYLAIS
HMLRKDPLDQTIGLIPRMAKGGHTALSRTETGQLRWYAASMAAGAVLVIGAVVLVAV
>Mature_617_residues
MNLLFLTFVFPLIGFLLLSFSRGRFSENLSALIGVGSIGLSAIVAAYVIWQFNVAPPEGGVYTQVLWRWMSVEGFQPNFA
LYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFSYTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYY
SNRNNGNAALKAFIVTRIGDVFMAIGLFILFQQLGTLNVQELLVKAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAALVQTDIKRILAYSTMSQIGY
MFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHHEQNIFKMGGLWKKLPLAYASFIVGGAALAALPLLTAGFYS
KDEILWEAFASGNHGLLYAGLVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFVGAMIVPPLHGV
LPESVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRFVTAIANSGIGRLLSAWWFAAWGFDWIYDKLFVKPYLAIS
HMLRKDPLDQTIGLIPRMAKGGHTALSRTETGQLRWYAASMAAGAVLVIGAVVLVAV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=387, Percent_Identity=39.7932816537468, Blast_Score=259, Evalue=7e-69,
Organism=Escherichia coli, GI1788614, Length=604, Percent_Identity=68.2119205298013, Blast_Score=816, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=33.5680751173709, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788827, Length=366, Percent_Identity=30.0546448087432, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788831, Length=366, Percent_Identity=28.1420765027322, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI2367154, Length=324, Percent_Identity=29.6296296296296, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788613, Length=394, Percent_Identity=26.9035532994924, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66512; Mature: 66512

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLFLTFVFPLIGFLLLSFSRGRFSENLSALIGVGSIGLSAIVAAYVIWQFNVAPPEGG
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
VYTQVLWRWMSVEGFQPNFALYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFS
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYYSNRNNGNAALKAFIVTRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VFMAIGLFILFQQLGTLNVQELLVKAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRILAYSTMSQIGYMFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
EQNIFKMGGLWKKLPLAYASFIVGGAALAALPLLTAGFYSKDEILWEAFASGNHGLLYAG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHH
LVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFVGAMIVPPLHGV
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHC
LPESVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRFVTAIANSGIGRLLSAWWFA
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
AWGFDWIYDKLFVKPYLAISHMLRKDPLDQTIGLIPRMAKGGHTALSRTETGQLRWYAAS
HHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHCCCCCCCEEEEHHH
MAAGAVLVIGAVVLVAV
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLLFLTFVFPLIGFLLLSFSRGRFSENLSALIGVGSIGLSAIVAAYVIWQFNVAPPEGG
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
VYTQVLWRWMSVEGFQPNFALYLDGLSVTMLGVVVGVGFLIHLFASWYMRGEAGYSRFFS
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YTNLFIASMLFLILGDNLLFIYFGWEGVGLCSYLLIGFYYSNRNNGNAALKAFIVTRIGD
HHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VFMAIGLFILFQQLGTLNVQELLVKAPEHFKVGDFWIVLATLMLLGGAVGKSAQLPLQTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFALAPDILHLVGIVGGVTLVLAGFAA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVQTDIKRILAYSTMSQIGYMFLALGVGAWEGAIFHLMTHAFFKALLFLASGAVIVACHH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
EQNIFKMGGLWKKLPLAYASFIVGGAALAALPLLTAGFYSKDEILWEAFASGNHGLLYAG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHH
LVGAFMTSLYTFRLIFIAFHGEAKTEAHAGHGIAHWLPLSVLIVLSTFVGAMIVPPLHGV
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHC
LPESVGHAGGEAKHSLEIASGAIALAGILLAALLFLGKRRFVTAIANSGIGRLLSAWWFA
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
AWGFDWIYDKLFVKPYLAISHMLRKDPLDQTIGLIPRMAKGGHTALSRTETGQLRWYAAS
HHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHCCCCCCCEEEEHHH
MAAGAVLVIGAVVLVAV
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]