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The map label for this gene is aceA [H]

Identifier: 77459824

GI number: 77459824

Start: 4071095

End: 4072420

Strand: Direct

Name: aceA [H]

Synonym: Pfl01_3602

Alternate gene names: 77459824

Gene position: 4071095-4072420 (Clockwise)

Preceding gene: 77459823

Following gene: 77459825

Centisome position: 63.23

GC content: 60.26

Gene sequence:

>1326_bases
ATGGCACTGACACGCGAACAGCAAATTGCAGCCCTTGAAAAAGACTGGGCTGAAAACCCGCGCTGGAAAGGCGTGACTCG
CAATTACTCCGCTGCTGACGTCGTCCGTCTGCGTGGCTCGGTTCAACCAGAGCACACCTTTGCAAAAATGGGCGCCGAAA
AACTGTGGAACCTGGTCACCCAGGGTGCCAAGCCGTCCTTCCGCCCAGAGAAAGACTTCGTCAACTGCATGGGCGCCCTG
ACCGGCGGCCAGGCTGTGCAGCAGGTCAAAGCCGGTATCCAGGCGATCTACCTGTCGGGCTGGCAAGTCGCTGCGGACAA
CAACTCCGCTGAATCGATGTACCCGGACCAGTCGCTGTACCCGGTGGACTCGGTTCCGACCGTGGTCAAGCGCATCAACA
ACTCGTTCCGTCGTGCCGACCAGATCCAGTGGAAAGCCGGCAAGAACCCGGGCGACGAAGGTTACATCGACTACTTCGCG
CCAATCGTGGCTGACGCTGAAGCCGGGTTCGGCGGCGTACTGAACGCCTACGAGCTGATGAAGAGCATGATCGAAGCAGG
CGCCGCCGGCGTTCACTTCGAAGACCAACTGGCTTCCGTGAAGAAATGCGGCCACATGGGCGGCAAGGTGCTGGTTCCAA
CCCAGGAAGCCGTGCAGAAGCTGACCGCTGCCCGTCTGGCTGCCGACGTTGCCGGCGTACCGACCATCATCCTGGCCCGT
ACCGACGCCAACGCTGCCGACCTGCTGACTTCCGACTGCGACCCGTACGACCAGCCGTTCGTGACTGGCACCCGTACCCA
GGAAGGTTTCTACAAGGTTCGTGCAGGTCTGGACCAGGCAATCGCCCGTGGCCTGGCCTACGCGCCGTACGCCGACCTGA
TCTGGTGCGAAACCGCCAAACCGGACCTGGACGAAGCCCGTCGTTTCGCTGAAGCGATCAAGAAGGAATATCCGGACCAG
ATCCTCTCTTACAACTGCTCGCCTTCCTTCAACTGGAAGAAAAACCTGGACGACGCGACCATCGCCAAGTTCCAGCGCGA
ACTGTCCGCCATGGGTTACAAGCACCAGTTCATTACCCTGGCCGGCATTCACAACATGTGGCACAGCATGTTCAACCTGG
CGCACGACTACGCCCGCAACGACATGACTGCCTACGTGAAGCTGCAAGAGCAGGAATTCGCTGACGCCGCCAAGGGTTAC
ACCTTCGTGGCTCACCAGCAGGAAGTGGGCACTGGCTACTTCGACGACATGACCACCGTGATCCAGGGCGGCACGTCCTC
GGTGACCGCGCTGACCGGTTCGACCGAAGAAGAACAGTTCCACTGA

Upstream 100 bases:

>100_bases
CGCCGAACCCGACCTGACCACCTAAGCTTCTGGTCAGCGAGCGCAAGGAATTTTCCACCGCAGAACAACTTTTCATAAAG
ACGCGACGAGGTTTATCTCC

Downstream 100 bases:

>100_bases
TCGACTTCGCCTGAGCGAACGGCCTTTGCGGACCGTATAGAAAGCTAACCGCACTGCCGAAAAACTGACGCCCCGACTGG
TTCGGGGCGTTTTTTTTGCC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MALTREQQIAALEKDWAENPRWKGVTRNYSAADVVRLRGSVQPEHTFAKMGAEKLWNLVTQGAKPSFRPEKDFVNCMGAL
TGGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLYPVDSVPTVVKRINNSFRRADQIQWKAGKNPGDEGYIDYFA
PIVADAEAGFGGVLNAYELMKSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGVPTIILAR
TDANAADLLTSDCDPYDQPFVTGTRTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAKPDLDEARRFAEAIKKEYPDQ
ILSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITLAGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGY
TFVAHQQEVGTGYFDDMTTVIQGGTSSVTALTGSTEEEQFH

Sequences:

>Translated_441_residues
MALTREQQIAALEKDWAENPRWKGVTRNYSAADVVRLRGSVQPEHTFAKMGAEKLWNLVTQGAKPSFRPEKDFVNCMGAL
TGGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLYPVDSVPTVVKRINNSFRRADQIQWKAGKNPGDEGYIDYFA
PIVADAEAGFGGVLNAYELMKSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGVPTIILAR
TDANAADLLTSDCDPYDQPFVTGTRTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAKPDLDEARRFAEAIKKEYPDQ
ILSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITLAGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGY
TFVAHQQEVGTGYFDDMTTVIQGGTSSVTALTGSTEEEQFH
>Mature_440_residues
ALTREQQIAALEKDWAENPRWKGVTRNYSAADVVRLRGSVQPEHTFAKMGAEKLWNLVTQGAKPSFRPEKDFVNCMGALT
GGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLYPVDSVPTVVKRINNSFRRADQIQWKAGKNPGDEGYIDYFAP
IVADAEAGFGGVLNAYELMKSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGVPTIILART
DANAADLLTSDCDPYDQPFVTGTRTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAKPDLDEARRFAEAIKKEYPDQI
LSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITLAGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGYT
FVAHQQEVGTGYFDDMTTVIQGGTSSVTALTGSTEEEQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=439, Percent_Identity=71.9817767653759, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=279, Percent_Identity=29.7491039426523, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982926, Length=427, Percent_Identity=57.6112412177986, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17561814, Length=427, Percent_Identity=57.6112412177986, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6320908, Length=331, Percent_Identity=34.7432024169184, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=254, Percent_Identity=34.6456692913386, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 48577; Mature: 48446

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTREQQIAALEKDWAENPRWKGVTRNYSAADVVRLRGSVQPEHTFAKMGAEKLWNLVT
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QGAKPSFRPEKDFVNCMGALTGGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLY
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCHHCCCCCCCC
PVDSVPTVVKRINNSFRRADQIQWKAGKNPGDEGYIDYFAPIVADAEAGFGGVLNAYELM
CCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
KSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGVPTIILAR
HHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEE
TDANAADLLTSDCDPYDQPFVTGTRTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAK
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
PDLDEARRFAEAIKKEYPDQILSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITL
CCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEH
AGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGYTFVAHQQEVGTGYFDDMTTV
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHH
IQGGTSSVTALTGSTEEEQFH
HCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
ALTREQQIAALEKDWAENPRWKGVTRNYSAADVVRLRGSVQPEHTFAKMGAEKLWNLVT
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QGAKPSFRPEKDFVNCMGALTGGQAVQQVKAGIQAIYLSGWQVAADNNSAESMYPDQSLY
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCHHCCCCCCCC
PVDSVPTVVKRINNSFRRADQIQWKAGKNPGDEGYIDYFAPIVADAEAGFGGVLNAYELM
CCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
KSMIEAGAAGVHFEDQLASVKKCGHMGGKVLVPTQEAVQKLTAARLAADVAGVPTIILAR
HHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEE
TDANAADLLTSDCDPYDQPFVTGTRTQEGFYKVRAGLDQAIARGLAYAPYADLIWCETAK
CCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
PDLDEARRFAEAIKKEYPDQILSYNCSPSFNWKKNLDDATIAKFQRELSAMGYKHQFITL
CCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEH
AGIHNMWHSMFNLAHDYARNDMTAYVKLQEQEFADAAKGYTFVAHQQEVGTGYFDDMTTV
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHH
IQGGTSSVTALTGSTEEEQFH
HCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]