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The map label for this gene is yiaY [H]

Identifier: 77457538

GI number: 77457538

Start: 1485621

End: 1486769

Strand: Direct

Name: yiaY [H]

Synonym: Pfl01_1311

Alternate gene names: 77457538

Gene position: 1485621-1486769 (Clockwise)

Preceding gene: 77457536

Following gene: 77457540

Centisome position: 23.07

GC content: 63.71

Gene sequence:

>1149_bases
ATGAGCAGCACCTTTTTCATTCCCGCGGTAAACATCATGGGCAGCGGCTGCCTCGATGAAGCCATGAATGCGATCCGCAA
CTACGGTTTTCGCAAGGCGCTGATCGTCACCGATGCCGGGCTGGCCAAGGCCGGCGTGGCGACGATGATTGCCGAGAAAC
TGGCGATGCAGGACATCGATTCGGTGGTCTTCGATGGCGCCAAACCCAATCCGAGCATCGCCAACGTTGAGGCGGGGCTG
GCGCTGCTCAAGGAGAGTCGCTGCGACTTCGTGGTGTCGTTGGGCGGCGGTTCGCCCCACGACTGCGCCAAGGGCATTGC
GTTGTGTGCCACCAACGGCGGGCAGATCCGCGACTACGAAGGCGTCGATCAATCGACCAAGCCACAACTGCCGCTGATCG
CCATCAACACCACCGCCGGCACCGCCAGCGAGATGACCCGGTTCTGCATCATCACCGACGAAACCCGTCACGTGAAAATG
GCCATCGTCGACCGCAACGTCACGCCGCTGCTGTCGGTCAACGACCCGGCGCTGATGGTCGCCATGCCGAAAAGCCTGAC
CGCCGCCACTGGCATGGACGCGCTGACCCATGCAATCGAAGCCTATGTGTCCACCGCCGCCAACCCGATCACCGACGCCT
GCGCGCTCAAGGCCATGACCCTGATCAGCAACAACCTGCGCCTGGTCGTGCGCGACGGCAGCGACCTGGCGGCGCGGGAA
AACATGGCGTATGCGCAGTTCCTCGCCGGCATGGCGTTCAACAATGCCTCCCTCGGTTACGTGCATGCGATGGCGCACCA
GTTGGGCGGTTTCTATGACTTGCCCCACGGTGTTTGCAACGCGGTGCTGCTGCCCCATGTGCAGACGTTCAACGCACAGG
TCTGTGCCGGTCGCCTGACCGATGTGGCCCACGCCATGGGCGCCGACATTCGTGGCTTCAGCCCGGAGGAGGGCGCGCAG
GCCGCGATTGCCGCGATCCGTTGCCTGGCCAGGGACGTGGAGATTCCCGGTGGCCTGCGTGATCTCGGCGCCAAGTGCAC
CGACATCCCGGTGCTCGCCGCCAACGCCCTGAAAGACGCCTGCGGCTTCACCAATCCGCGAGTGGCGGATCAGCGGCAGA
TCGAGGAGATTTTCCGCAGCGCGTTTTAA

Upstream 100 bases:

>100_bases
GGCATTGAGCCAGATCAACATCCGCCGTGACCGATCGGTCGATCCTTTGCGCACCCGCCGAATTGCAAGCATCGATTCGG
CCCCAGCCAGGAGACGCGCC

Downstream 100 bases:

>100_bases
GCGGGCTGATGATCGGGCGTTAACCTCGTGCAGAGCACCGCGCCAAATGCCAGAACGCAGCACAGCATCGATAGCGGCCA
TGCCTGCGGACTGGCGAGCA

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSSTFFIPAVNIMGSGCLDEAMNAIRNYGFRKALIVTDAGLAKAGVATMIAEKLAMQDIDSVVFDGAKPNPSIANVEAGL
ALLKESRCDFVVSLGGGSPHDCAKGIALCATNGGQIRDYEGVDQSTKPQLPLIAINTTAGTASEMTRFCIITDETRHVKM
AIVDRNVTPLLSVNDPALMVAMPKSLTAATGMDALTHAIEAYVSTAANPITDACALKAMTLISNNLRLVVRDGSDLAARE
NMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAVLLPHVQTFNAQVCAGRLTDVAHAMGADIRGFSPEEGAQ
AAIAAIRCLARDVEIPGGLRDLGAKCTDIPVLAANALKDACGFTNPRVADQRQIEEIFRSAF

Sequences:

>Translated_382_residues
MSSTFFIPAVNIMGSGCLDEAMNAIRNYGFRKALIVTDAGLAKAGVATMIAEKLAMQDIDSVVFDGAKPNPSIANVEAGL
ALLKESRCDFVVSLGGGSPHDCAKGIALCATNGGQIRDYEGVDQSTKPQLPLIAINTTAGTASEMTRFCIITDETRHVKM
AIVDRNVTPLLSVNDPALMVAMPKSLTAATGMDALTHAIEAYVSTAANPITDACALKAMTLISNNLRLVVRDGSDLAARE
NMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAVLLPHVQTFNAQVCAGRLTDVAHAMGADIRGFSPEEGAQ
AAIAAIRCLARDVEIPGGLRDLGAKCTDIPVLAANALKDACGFTNPRVADQRQIEEIFRSAF
>Mature_381_residues
SSTFFIPAVNIMGSGCLDEAMNAIRNYGFRKALIVTDAGLAKAGVATMIAEKLAMQDIDSVVFDGAKPNPSIANVEAGLA
LLKESRCDFVVSLGGGSPHDCAKGIALCATNGGQIRDYEGVDQSTKPQLPLIAINTTAGTASEMTRFCIITDETRHVKMA
IVDRNVTPLLSVNDPALMVAMPKSLTAATGMDALTHAIEAYVSTAANPITDACALKAMTLISNNLRLVVRDGSDLAAREN
MAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAVLLPHVQTFNAQVCAGRLTDVAHAMGADIRGFSPEEGAQA
AIAAIRCLARDVEIPGGLRDLGAKCTDIPVLAANALKDACGFTNPRVADQRQIEEIFRSAF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=383, Percent_Identity=27.9373368146214, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=69.8162729658793, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1789163, Length=384, Percent_Identity=41.40625, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=37.3015873015873, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1787493, Length=409, Percent_Identity=30.5623471882641, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1789386, Length=330, Percent_Identity=26.3636363636364, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=410, Percent_Identity=27.0731707317073, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321181, Length=386, Percent_Identity=54.9222797927461, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24657991, Length=409, Percent_Identity=26.161369193154, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40175; Mature: 40043

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTFFIPAVNIMGSGCLDEAMNAIRNYGFRKALIVTDAGLAKAGVATMIAEKLAMQDID
CCCEEEEECHHHHCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
SVVFDGAKPNPSIANVEAGLALLKESRCDFVVSLGGGSPHDCAKGIALCATNGGQIRDYE
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEECCCCCEECCC
GVDQSTKPQLPLIAINTTAGTASEMTRFCIITDETRHVKMAIVDRNVTPLLSVNDPALMV
CCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCEEEECCCCEEEE
AMPKSLTAATGMDALTHAIEAYVSTAANPITDACALKAMTLISNNLRLVVRDGSDLAARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
NMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAVLLPHVQTFNAQVCAGRLT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCHHHHHHHHH
DVAHAMGADIRGFSPEEGAQAAIAAIRCLARDVEIPGGLRDLGAKCTDIPVLAANALKDA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHH
CGFTNPRVADQRQIEEIFRSAF
HCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SSTFFIPAVNIMGSGCLDEAMNAIRNYGFRKALIVTDAGLAKAGVATMIAEKLAMQDID
CCEEEEECHHHHCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
SVVFDGAKPNPSIANVEAGLALLKESRCDFVVSLGGGSPHDCAKGIALCATNGGQIRDYE
HHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCEEEEECCCCCEECCC
GVDQSTKPQLPLIAINTTAGTASEMTRFCIITDETRHVKMAIVDRNVTPLLSVNDPALMV
CCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEEECCCCEEEECCCCEEEE
AMPKSLTAATGMDALTHAIEAYVSTAANPITDACALKAMTLISNNLRLVVRDGSDLAARE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
NMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYDLPHGVCNAVLLPHVQTFNAQVCAGRLT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCHHHHHHHHH
DVAHAMGADIRGFSPEEGAQAAIAAIRCLARDVEIPGGLRDLGAKCTDIPVLAANALKDA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHH
CGFTNPRVADQRQIEEIFRSAF
HCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]